2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage Autophagy Apoptosis
  3. NAMPT HDAC Autophagy Apoptosis
  4. Nampt-IN-3

Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death.

For research use only. We do not sell to patients.

Nampt-IN-3 Chemical Structure

Nampt-IN-3 Chemical Structure

CAS No. : 2121591-52-2

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10 mM * 1 mL in DMSO
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 USD 388 In-stock
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10 mM * 1 mL in DMSO USD 388 In-stock
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5 mg USD 350 In-stock
10 mg USD 560 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Nampt-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
2.4 μM
Compound: 35
Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28885834]
HepG2 IC50
4.5 μM
Compound: 35
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28885834]
MDA-MB-231 IC50
10 μM
Compound: 35
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28885834]
Molecular Weight

503.55

Formula

C29H25N7O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CN(CC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)N=N2)C=C1)NCC5=CC=CN=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (258.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9859 mL 9.9295 mL 19.8590 mL
5 mM 0.3972 mL 1.9859 mL 3.9718 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9859 mL 9.9295 mL 19.8590 mL 49.6475 mL
5 mM 0.3972 mL 1.9859 mL 3.9718 mL 9.9295 mL
10 mM 0.1986 mL 0.9930 mL 1.9859 mL 4.9648 mL
15 mM 0.1324 mL 0.6620 mL 1.3239 mL 3.3098 mL
20 mM 0.0993 mL 0.4965 mL 0.9930 mL 2.4824 mL
25 mM 0.0794 mL 0.3972 mL 0.7944 mL 1.9859 mL
30 mM 0.0662 mL 0.3310 mL 0.6620 mL 1.6549 mL
40 mM 0.0496 mL 0.2482 mL 0.4965 mL 1.2412 mL
50 mM 0.0397 mL 0.1986 mL 0.3972 mL 0.9930 mL
60 mM 0.0331 mL 0.1655 mL 0.3310 mL 0.8275 mL
80 mM 0.0248 mL 0.1241 mL 0.2482 mL 0.6206 mL
100 mM 0.0199 mL 0.0993 mL 0.1986 mL 0.4965 mL
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Nampt-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nampt-IN-32121591-52-2NAMPTHDACAutophagyApoptosisNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorHistone deacetylasesInhibitorinhibitorinhibit

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