2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. LLL3

LLL3 (CLT-005) is a STAT3 inhibitor. LLL3 inhibits dimerization and phosphorylation of STAT3, thereby preventing intraconuclear transfer of STAT3 and inhibits the expression of STAT3 dependent genes, which encode proteins such as Bcl-xL and cyclin D1. In addition, LLL3 can induce cell growth inhibition and apoptosis in human breast cancer and rhabdomyosarcoma cells via the caspase pathway. LLL3 can be used in the study of STAT3 persistent activation types of cancer.

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LLL3 Chemical Structure

LLL3 Chemical Structure

CAS No. : 63972-38-3

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Based on 1 publication(s) in Google Scholar

LLL3 Related Antibodies

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STAT3 STAT5 STAT6 STAT1

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Description

LLL3 (CLT-005) is a STAT3 inhibitor. LLL3 inhibits dimerization and phosphorylation of STAT3, thereby preventing intraconuclear transfer of STAT3 and inhibits the expression of STAT3 dependent genes, which encode proteins such as Bcl-xL and cyclin D1. In addition, LLL3 can induce cell growth inhibition and apoptosis in human breast cancer and rhabdomyosarcoma cells via the caspase pathway. LLL3 can be used in the study of STAT3 persistent activation types of cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
11.5 μM
Compound: LLL3
Antiproliferative activity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
Antiproliferative activity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 24176397]
DU-145 IC50
16.2 μM
Compound: 1
Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay
[PMID: 18006313]
HT-29 IC50
10.4 μM
Compound: LLL3
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 24176397]
LNCaP IC50
34.1 μM
Compound: 1
Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay
Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay
[PMID: 18006313]
MCF7 IC50
88.5 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 18006313]
PC-3 IC50
13.4 μM
Compound: 1
Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
[PMID: 18006313]
Molecular Weight

266.25

Formula

C16H10O4
CAS No.
SMILES

O=C1C2=C(C(O)=CC=C2)C(C3=CC=CC(C(C)=O)=C13)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LLL3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LLL363972-38-3CLT-005LLL 3LLL-3CLT005CLT 005STATApoptosisSTAT3dimerizationphosphorylationinhibitorapoptosisInhibitorinhibit

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