LLL3 (Synonyms: CLT-005)

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LLL3 (CLT-005) is a STAT3 inhibitor. LLL3 inhibits dimerization and phosphorylation of STAT3, thereby preventing intraconuclear transfer of STAT3 and inhibits the expression of STAT3 dependent genes, which encode proteins such as Bcl-xL and cyclin D1. In addition, LLL3 can induce cell growth inhibition and apoptosis in human breast cancer and rhabdomyosarcoma cells via the caspase pathway. LLL3 can be used in the study of STAT3 persistent activation types of cancer.

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LLL3 Chemical Structure

CAS No. : 63972-38-3

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.5 μM Compound: LLL3	Antiproliferative activity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay Antiproliferative activity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 24176397]
DU-145	IC₅₀	16.2 μM Compound: 1	Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay	[PMID: 18006313]
HT-29	IC₅₀	10.4 μM Compound: LLL3	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay	[PMID: 24176397]
LNCaP	IC₅₀	34.1 μM Compound: 1	Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay	[PMID: 18006313]
MCF7	IC₅₀	88.5 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 18006313]
PC-3	IC₅₀	13.4 μM Compound: 1	Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay	[PMID: 18006313]

Molecular Weight

266.25

Formula

C₁₆H₁₀O₄

CAS No.

63972-38-3

SMILES

O=C1C2=C(C(O)=CC=C2)C(C3=CC=CC(C(C)=O)=C13)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fuh B, et al. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model[J]. British journal of cancer, 2009, 100(1): 106-112. [Content Brief]

[2]. Lavecchia A, et al. Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature[J]. Expert opinion on therapeutic patents, 2014, 24(4): 383-400. [Content Brief]

LLL3 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LLL363972-38-3CLT-005LLL 3LLL-3CLT005CLT 005STATApoptosisSTAT3dimerizationphosphorylationinhibitorapoptosisInhibitorinhibit

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