2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Manganese(salen) chloride

Manganese(salen) chloride  (Synonyms: EUK-8)

Cat. No.: HY-W001583 Purity: 97.38%
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Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.

For research use only. We do not sell to patients.

Manganese(salen) chloride Chemical Structure

Manganese(salen) chloride Chemical Structure

CAS No. : 53177-12-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in DMSO USD 28 In-stock
Solid
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10 mg USD 40 In-stock
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Based on 1 publication(s) in Google Scholar

Manganese(salen) chloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Manganese(salen) chloride

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  • Purity & Documentation

  • References

  • Customer Review

Description

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

In Vitro

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Manganese(salen) chloride Related Antibodies
In Vivo

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3]
Dosage: 25 mg/kg/day
Administration: I.p. 3 times a week for 4 weeks
Result: Prevented myocardial oxidant damage provoked by biomechanical stress.
Improved survival following biomechanical stress.
Prevented functional and geometrical deterioration in response to pressure overload.
Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
Molecular Weight

356.69

Formula

C16H14ClMnN2O2
CAS No.
Appearance

Solid

Color

Brown to dark brown

SMILES

[Cl-][Mn+3]123[O-]C4=C(C=[N]1CC[N]2=CC5=C([O-]3)C=CC=C5)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (23.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8036 mL 14.0178 mL 28.0355 mL
5 mM 0.5607 mL 2.8036 mL 5.6071 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.38%

SDS (393 KB)

COA (263 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8036 mL 14.0178 mL 28.0355 mL 70.0889 mL
5 mM 0.5607 mL 2.8036 mL 5.6071 mL 14.0178 mL
10 mM 0.2804 mL 1.4018 mL 2.8036 mL 7.0089 mL
15 mM 0.1869 mL 0.9345 mL 1.8690 mL 4.6726 mL
20 mM 0.1402 mL 0.7009 mL 1.4018 mL 3.5044 mL
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Manganese(salen) chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Manganese(salen)53177-12-1EUK-8EUK8EUK 8Reactive Oxygen SpeciessuperoxidedismutasecatalasemimeticantioxidantoxyradicalscavengingInhibitorinhibitorinhibit

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