2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CXCR HIV
  4. Mavorixafor hydrochloride

Mavorixafor hydrochloride  (Synonyms: AMD-070 hydrochloride; AMD-11070 hydrochloride)

Cat. No.: HY-50101C Purity: 99.10%
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Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome.

For research use only. We do not sell to patients.

Mavorixafor hydrochloride Chemical Structure

Mavorixafor hydrochloride Chemical Structure

CAS No. : 880549-30-4

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Mavorixafor hydrochloride:

Mavorixafor hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome[1].

IC50 & Target[1]

125I-CXCL12-CXCR4

13 nM (IC50)

HIV-1 (NL4.3 strain)

1 nM (IC50, In MT-4 cells)

HIV-1 (NL4.3 strain)

9 nM (IC50, In PBMCs)

HIV-1 (NL4.3 strain)

3 nM (IC90, In MT-4 cells)

HIV-1 (NL4.3 strain)

26 nM (IC90, In PBMCs)

In Vitro

Mavorixafor (AMD-070) hydrochloride shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2)[1].
Mavorixafor (6.6 μM; 14-21 days) hydrochloride significantly suppresses the anchorage-dependent growth of the B88-SDF-1 cells. Mavorixafor hydrochloride significantly impaires the enhanced motility of B88-SDF-1 cells. Mavorixafor hydrochloride also significantly inhibits the migration and Matrigel invasion of B88-SDF-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mavorixafor hydrochloride Related Antibodies

Cell Invasion Assay[2]

Cell Line: B88-SDF-1 cells
Concentration: 6.6 µM
Incubation Time: 48 h
Result: Significantly inhibited the migration and Matrigel invasion of B88-SDF-1 cells.
In Vivo

Mavorixafor (2 mg/kg; po; once a day; for 49 days) hydrochloride significantly inhibits the lung metastasis of B88 SDF 1 cells in nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (8 weeks of age) injected with B88-SDF-1 cells[2]
Dosage: 2 mg/kg
Administration: Oral administration; once a day; for 49 days
Result: A significant reduction in the number of metastatic lung nodules was observed in the mice.
Molecular Weight

385.93

Formula

C21H28ClN5
CAS No.
Appearance

Viscous Liquid

Color

Light yellow to brown

SMILES

NCCCCN(CC1=NC2=CC=CC=C2N1)[C@H]3CCCC4=C3N=CC=C4.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (259.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5911 mL 12.9557 mL 25.9114 mL
5 mM 0.5182 mL 2.5911 mL 5.1823 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5911 mL 12.9557 mL 25.9114 mL 64.7786 mL
5 mM 0.5182 mL 2.5911 mL 5.1823 mL 12.9557 mL
10 mM 0.2591 mL 1.2956 mL 2.5911 mL 6.4779 mL
15 mM 0.1727 mL 0.8637 mL 1.7274 mL 4.3186 mL
20 mM 0.1296 mL 0.6478 mL 1.2956 mL 3.2389 mL
25 mM 0.1036 mL 0.5182 mL 1.0365 mL 2.5911 mL
30 mM 0.0864 mL 0.4319 mL 0.8637 mL 2.1593 mL
40 mM 0.0648 mL 0.3239 mL 0.6478 mL 1.6195 mL
50 mM 0.0518 mL 0.2591 mL 0.5182 mL 1.2956 mL
60 mM 0.0432 mL 0.2159 mL 0.4319 mL 1.0796 mL
80 mM 0.0324 mL 0.1619 mL 0.3239 mL 0.8097 mL
100 mM 0.0259 mL 0.1296 mL 0.2591 mL 0.6478 mL
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Mavorixafor hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mavorixafor880549-30-4AMD-070AMD-11070AMD070AMD 070AMD11070AMD 11070CXCRHIVCXC chemokine receptorsC-X-C motif chemokine receptorsHuman immunodeficiency virusCXCR4HIV-1Inhibitorinhibitorinhibit

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