mTOR inhibitor WYE-28

Cat. No.: HY-118717 Purity: 99.25%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC₅₀)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T_1/2) in nude mouse microsomes of 13 min.

For research use only. We do not sell to patients.

mTOR inhibitor WYE-28 Chemical Structure

CAS No. : 1062172-60-4

Size Price Stock Quantity

1 mg USD 105 In-stock

Estimated Time of Arrival: December 31

5 mg USD 420 In-stock

Estimated Time of Arrival: December 31

10 mg USD 720 In-stock

Estimated Time of Arrival: December 31

25 mg USD 1440 In-stock

Estimated Time of Arrival: December 31

50 mg Get quote

100 mg Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

mTOR inhibitor WYE-28 Related Antibodies

Powered by Bioz See more details on Bioz

Featured Recommendations

•Related Screening Libraries:

Bioactive Compound Library Plus

•Related Small Molecules:

•Related Proteins:

View All mTOR Isoform Specific Products:

View All Isoforms

mTOR mTORC1 mTORC2

Biological Activity

Purity & Documentation

References

Customer Review

Description

mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC₅₀)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T_1/2) in nude mouse microsomes of 13 min^[1].

Cellular Effect

Cell Line Type Value Description References

HEK293 IC₅₀
0.08 nM
Compound: 28

Inhibition of flag-tagged truncated human mTOR (1360-2549) expressed in HEK293 cells by DELFIA assay

Inhibition of flag-tagged truncated human mTOR (1360-2549) expressed in HEK293 cells by DELFIA assay
[PMID: 19645448]

LNCaP IC₅₀
< 1 nM
Compound: 28

Cytotoxicity against human LNCAP cells after 3 days by MTS assay

Cytotoxicity against human LNCAP cells after 3 days by MTS assay
[PMID: 19645448]

Molecular Weight
586.64

Formula
C₃₀H₃₄N₈O₅

CAS No.
1062172-60-4

Appearance

Solid

Color

White to off-white

SMILES
O=C(N1CCC(N2N=CC3=C(N=C(N=C32)C4=CC=C(C=C4)NC(NC5=CC=C(C=C5)CO)=O)N6CCOCC6)CC1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

In solvent -80°C 6 months

-20°C 1 month

Solvent & Solubility
In Vitro:

DMSO : 60 mg/mL (102.28 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass 1 mg 5 mg 10 mg

1 mM 1.7046 mL 8.5231 mL 17.0462 mL

5 mM 0.3409 mL 1.7046 mL 3.4092 mL

10 mM 0.1705 mL 0.8523 mL 1.7046 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

=
Concentration

×
Volume

×
Molecular Weight *

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

C1

×
Volume _(start)

V1

=
Concentration _(final)

C2

×
Volume _(final)

V2

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg

Animal weight
(per animal)
g

Dosing volume
(per animal)
μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.75%
Select Batch:

Data Sheet (269 KB) SDS (251 KB)
COA (249 KB) HNMR (287 KB) LCMS (94 KB)
Handling Instructions (2659 KB)

References

[1]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. [Content Brief]

[1]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 1.7046 mL 8.5231 mL 17.0462 mL 42.6156 mL

5 mM 0.3409 mL 1.7046 mL 3.4092 mL 8.5231 mL

10 mM 0.1705 mL 0.8523 mL 1.7046 mL 4.2616 mL

15 mM 0.1136 mL 0.5682 mL 1.1364 mL 2.8410 mL

20 mM 0.0852 mL 0.4262 mL 0.8523 mL 2.1308 mL

25 mM 0.0682 mL 0.3409 mL 0.6818 mL 1.7046 mL

30 mM 0.0568 mL 0.2841 mL 0.5682 mL 1.4205 mL

40 mM 0.0426 mL 0.2131 mL 0.4262 mL 1.0654 mL

50 mM 0.0341 mL 0.1705 mL 0.3409 mL 0.8523 mL

60 mM 0.0284 mL 0.1421 mL 0.2841 mL 0.7103 mL

80 mM 0.0213 mL 0.1065 mL 0.2131 mL 0.5327 mL

100 mM 0.0170 mL 0.0852 mL 0.1705 mL 0.4262 mL

Rating

Lot Number *

Submit an Image
No file chosen (Maximum size is: 1024 Kb)

PubMed ID

If you have published this work, please enter the PubMed ID.

Show My Name

Your name will appear on the site.

Email

Remarks

mTOR inhibitor WYE-28 Related Classifications

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

PI3K/Akt/mTOR

mTOR

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mTOR inhibitor WYE-281062172-60-4mTOR inhibitor WYE28mTOR inhibitor WYE 28mTORMammalian target of RapamycinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Size	Price	Stock	Quantity
1 mg	USD 105	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1440	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

DMSO	1 mM	1.7046 mL	8.5231 mL	17.0462 mL	42.6156 mL
	5 mM	0.3409 mL	1.7046 mL	3.4092 mL	8.5231 mL
	10 mM	0.1705 mL	0.8523 mL	1.7046 mL	4.2616 mL
	15 mM	0.1136 mL	0.5682 mL	1.1364 mL	2.8410 mL
	20 mM	0.0852 mL	0.4262 mL	0.8523 mL	2.1308 mL
	25 mM	0.0682 mL	0.3409 mL	0.6818 mL	1.7046 mL
	30 mM	0.0568 mL	0.2841 mL	0.5682 mL	1.4205 mL
	40 mM	0.0426 mL	0.2131 mL	0.4262 mL	1.0654 mL
	50 mM	0.0341 mL	0.1705 mL	0.3409 mL	0.8523 mL
	60 mM	0.0284 mL	0.1421 mL	0.2841 mL	0.7103 mL
	80 mM	0.0213 mL	0.1065 mL	0.2131 mL	0.5327 mL
	100 mM	0.0170 mL	0.0852 mL	0.1705 mL	0.4262 mL

Name
Email *

	Sorry, but the email address you supplied was invalid.

mTOR inhibitor WYE-28

mTOR inhibitor WYE-28 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mTOR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

mTOR inhibitor WYE-28 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report