N-Methylparoxetine

Cat. No.: HY-Z3832 Purity: 99.97%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

N-Methylparoxetine is a derivative of Paroxetine that induces Apoptosis NSCLC cells by activating mitogen-activated protein kinase ( MAPK). N-Methylparoxetine has antitumor activity.

For research use only. We do not sell to patients.

N-Methylparoxetine Chemical Structure

CAS No. : 110429-36-2

Size	Stock	Quantity
Free Sample (0.1 - 0.5 mg)	Apply Now
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote	Estimated Time of Arrival: December 31
10 g	Get quote	Estimated Time of Arrival: December 31
50 g	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N-Methylparoxetine is a derivative of Paroxetine that induces Apoptosis NSCLC cells by activating mitogen-activated protein kinase ( MAPK). N-Methylparoxetine has antitumor activity^[1].

Molecular Weight

343.39

Formula

C₂₀H₂₂FNO₃

CAS No.

110429-36-2

Appearance

Solid

Color

White to off-white

SMILES

CN(C1)CC[C@@H](C2=CC=C(C=C2)F)[C@@H]1COC3=CC=C(OCO4)C4=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (291.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9121 mL	14.5607 mL	29.1214 mL
5 mM	0.5824 mL	2.9121 mL	5.8243 mL
10 mM	0.2912 mL	1.4561 mL	2.9121 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (270 KB) SDS (624 KB)

COA (310 KB) HNMR (122 KB) CNMR (128 KB) RP-HPLC (280 KB) MS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Wang K, et al. N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Jul 11;20(14):3415. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9121 mL	14.5607 mL	29.1214 mL	72.8035 mL
	5 mM	0.5824 mL	2.9121 mL	5.8243 mL	14.5607 mL
	10 mM	0.2912 mL	1.4561 mL	2.9121 mL	7.2804 mL
	15 mM	0.1941 mL	0.9707 mL	1.9414 mL	4.8536 mL
	20 mM	0.1456 mL	0.7280 mL	1.4561 mL	3.6402 mL
	25 mM	0.1165 mL	0.5824 mL	1.1649 mL	2.9121 mL
	30 mM	0.0971 mL	0.4854 mL	0.9707 mL	2.4268 mL
	40 mM	0.0728 mL	0.3640 mL	0.7280 mL	1.8201 mL
	50 mM	0.0582 mL	0.2912 mL	0.5824 mL	1.4561 mL
	60 mM	0.0485 mL	0.2427 mL	0.4854 mL	1.2134 mL
	80 mM	0.0364 mL	0.1820 mL	0.3640 mL	0.9100 mL
	100 mM	0.0291 mL	0.1456 mL	0.2912 mL	0.7280 mL