2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Nusinersen

Nusinersen is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.

For research use only. We do not sell to patients.

RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G)

Nusinersen Chemical Structure

CAS No. : 1258984-36-9

Size Price Stock Quantity
1 mg USD 420 In-stock
5 mg USD 1246 In-stock
10 mg USD 1890 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Nusinersen:

Nusinersen Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nusinersen

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nusinersen is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein[1].

In Vitro

Nusinersen is an SMN-ASO that increases SMN levels by blocking an intronic splice silencer in SMN2, thereby facilitating the exon 7 inclusion and generation of FL-SMN2 transcripts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nusinersen Related Antibodies
Clinical Trial
Molecular Weight

7127.30

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G)
SMILES

[Nusinersen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Purity & Documentation

Purity: 98.91%

SDS (480 KB)

COA (245 KB) RP-HPLC (279 KB)

Handling Instructions (2659 KB)
References
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Nusinersen Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nusinersen1258984-36-9DNA/RNA SynthesisSMAspinalmuscularatrophySMN2Inhibitorinhibitorinhibit

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HY-112980
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