2. Anti-infection Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Fungal Apoptosis Caspase Bcl-2 Family MDM-2/p53 PARP
  4. Oxychlororaphine

Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer.

For research use only. We do not sell to patients.

Oxychlororaphine Chemical Structure

Oxychlororaphine Chemical Structure

CAS No. : 550-89-0

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Based on 1 publication(s) in Google Scholar

Oxychlororaphine Related Antibodies

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • Purity & Documentation

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  • Customer Review

Description

Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer[1][2].

In Vitro

Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM[2].
Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein[2].
Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase[2].
Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxychlororaphine Related Antibodies

Cell Viability Assay[2]

Cell Line: A549, HeLa, and SW480 cancer cell lines
Concentration: 1, 2, 4, 8, 16, 32, 64, 128, and 256 μM
Incubation Time: 24 hours
Result: Inhibited cell proliferative in a dose-dependent manner.
Molecular Weight

223.23

Formula

C13H9N3O
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C1=CC=CC2=NC3=CC=CC=C3N=C21)N
Structure Classification
Initial Source

Phytopathogenic bacteria
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4797 mL 22.3984 mL 44.7968 mL
5 mM 0.8959 mL 4.4797 mL 8.9594 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.90%

COA (251 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4797 mL 22.3984 mL 44.7968 mL 111.9921 mL
5 mM 0.8959 mL 4.4797 mL 8.9594 mL 22.3984 mL
10 mM 0.4480 mL 2.2398 mL 4.4797 mL 11.1992 mL
15 mM 0.2986 mL 1.4932 mL 2.9865 mL 7.4661 mL
20 mM 0.2240 mL 1.1199 mL 2.2398 mL 5.5996 mL
25 mM 0.1792 mL 0.8959 mL 1.7919 mL 4.4797 mL
30 mM 0.1493 mL 0.7466 mL 1.4932 mL 3.7331 mL
40 mM 0.1120 mL 0.5600 mL 1.1199 mL 2.7998 mL
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Oxychlororaphine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxychlororaphine550-89-0FungalApoptosisCaspaseBcl-2 FamilyMDM-2/p53PARPpoly ADP ribose polymerasePantoeacytotoxicityantifungalanticancerA549HeLaSW480Inhibitorinhibitorinhibit

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