p38α inhibitor 5

Cat. No.: HY-159799: FAQs
Data Sheet Handling Instructions

Molarity Calculator

p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798).

For research use only. We do not sell to patients.

p38α inhibitor 5 Chemical Structure

CAS No. : 2550397-96-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All p38 MAPK Isoform Specific Products:

View All Isoforms

p38 MAPK p38α p38β MAPK13 p38δ p38γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798)^[1].

Molecular Weight

529.37

Formula

C₂₆H₂₃BrF₂N₂O₃

CAS No.

2550397-96-9

SMILES

CC(C(N1C(C)=CC(OCC2=CC=C(C=C2F)F)=C(C1=O)Br)=C3)=CC=C3C(NCCCC#C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (188.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8890 mL	9.4452 mL	18.8904 mL
5 mM	0.3778 mL	1.8890 mL	3.7781 mL
10 mM	0.1889 mL	0.9445 mL	1.8890 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cubillos-Rojas M, et al. Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α. Cancers (Basel). 2023 Jan 18;15(3):611. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8890 mL	9.4452 mL	18.8904 mL	47.2259 mL
	5 mM	0.3778 mL	1.8890 mL	3.7781 mL	9.4452 mL
	10 mM	0.1889 mL	0.9445 mL	1.8890 mL	4.7226 mL
	15 mM	0.1259 mL	0.6297 mL	1.2594 mL	3.1484 mL
	20 mM	0.0945 mL	0.4723 mL	0.9445 mL	2.3613 mL
	25 mM	0.0756 mL	0.3778 mL	0.7556 mL	1.8890 mL
	30 mM	0.0630 mL	0.3148 mL	0.6297 mL	1.5742 mL
	40 mM	0.0472 mL	0.2361 mL	0.4723 mL	1.1806 mL
	50 mM	0.0378 mL	0.1889 mL	0.3778 mL	0.9445 mL
	60 mM	0.0315 mL	0.1574 mL	0.3148 mL	0.7871 mL
	80 mM	0.0236 mL	0.1181 mL	0.2361 mL	0.5903 mL
	100 mM	0.0189 mL	0.0945 mL	0.1889 mL	0.4723 mL