2. Apoptosis Stem Cell/Wnt NF-κB
  3. MDM-2/p53 Wnt IKK Apoptosis Caspase
  4. PAWI-2

PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model.

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PAWI-2 Chemical Structure

PAWI-2 Chemical Structure

CAS No. : 1448427-02-8

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PAWI-2 Related Antibodies

Top Publications Citing Use of Products

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IKK-α IKK-β IKK IKKε TBK1

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model[1][2].

IC50 & Target[1]

Caspase 3

 

Caspase-7

 

Molecular Weight

371.45

Formula

C19H21N3O3S
CAS No.
SMILES

O=C1N(C2=CC=C(S(=O)(N3CCN(C)C4=C3C=CC=C4)=O)C=C2)CCC1
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Purity & Documentation
References
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PAWI-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAWI-21448427-02-8PAWI2PAWI 2MDM-2/p53WntIKKApoptosisCaspaseIκB kinaseI kappa B kinase pancreatic cancerhPCSCsTBK1 phosphorylationInhibitorinhibitorinhibit

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