Phenylephrine-2,4,6-d₃ hydrochloride (Synonyms: (R)-(-)-Phenylephrine-2,4,6-d₃ (hydrochloride); L-Phenylephrine-2,4,6-d₃ (hydrochloride))

Name: Phenylephrine-2,4,6-d 3 hydrochloride
Brand: MedChemExpress
SKU: HY-B0471S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0471S1 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

For research use only. We do not sell to patients.

Phenylephrine-2,4,6-d<sub>3</sub> hydrochloride Chemical Structure

Phenylephrine-2,4,6-d₃ hydrochloride Chemical Structure

CAS No. : 1276197-50-2

Size	Price	Stock	Quantity
1 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 490	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Phenylephrine-2,4,6-d₃ hydrochloride:

Phenylephrine hydrochloride In-stock

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

206.68

Formula

C₉H₁₁D₃ClNO₂

CAS No.

1276197-50-2

Unlabeled CAS

61-76-7

Appearance

Solid

Color

White to off-white

SMILES

CNC[C@@H](C1=C([2H])C(O)=C([2H])C=C1[2H])O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (604.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8384 mL	24.1920 mL	48.3840 mL
5 mM	0.9677 mL	4.8384 mL	9.6768 mL
10 mM	0.4838 mL	2.4192 mL	4.8384 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (6.05 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (6.05 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (6.05 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (250 KB) HNMR (99 KB) RP-HPLC (568 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35. [Content Brief]

[3]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. [Content Brief]

[4]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. [Content Brief]

[5]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. [Content Brief]

[6]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	4.8384 mL	24.1920 mL	48.3840 mL	120.9599 mL
	5 mM	0.9677 mL	4.8384 mL	9.6768 mL	24.1920 mL
	10 mM	0.4838 mL	2.4192 mL	4.8384 mL	12.0960 mL
	15 mM	0.3226 mL	1.6128 mL	3.2256 mL	8.0640 mL
	20 mM	0.2419 mL	1.2096 mL	2.4192 mL	6.0480 mL
	25 mM	0.1935 mL	0.9677 mL	1.9354 mL	4.8384 mL
	30 mM	0.1613 mL	0.8064 mL	1.6128 mL	4.0320 mL
	40 mM	0.1210 mL	0.6048 mL	1.2096 mL	3.0240 mL
	50 mM	0.0968 mL	0.4838 mL	0.9677 mL	2.4192 mL
	60 mM	0.0806 mL	0.4032 mL	0.8064 mL	2.0160 mL
	80 mM	0.0605 mL	0.3024 mL	0.6048 mL	1.5120 mL
	100 mM	0.0484 mL	0.2419 mL	0.4838 mL	1.2096 mL

Phenylephrine-2,4,6-d₃ hydrochloride Related Classifications

Endocrinology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenylephrine-2,4,6-d₃1276197-50-2(R)-(-)-Phenylephrine-2,4,6-d₃L-Phenylephrine-2,4,6-d₃Adrenergic ReceptorEndogenous MetaboliteBeta ReceptorInhibitorinhibitorinhibit

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Phenylephrine-2,4,6-d3 hydrochloride (Synonyms: (R)-(-)-Phenylephrine-2,4,6-d3 (hydrochloride); L-Phenylephrine-2,4,6-d3 (hydrochloride))

Customer Review

Other Forms of Phenylephrine-2,4,6-d3 hydrochloride:

Phenylephrine-2,4,6-d3 hydrochloride Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Adrenergic Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Phenylephrine-2,4,6-d3 hydrochloride Related Antibodies

Molarity Calculator

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Complete Stock Solution Preparation Table

Phenylephrine-2,4,6-d3 hydrochloride Related Classifications

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SAFETY DATA SHEET (SDS)

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Phenylephrine-2,4,6-d₃ hydrochloride (Synonyms: (R)-(-)-Phenylephrine-2,4,6-d₃ (hydrochloride); L-Phenylephrine-2,4,6-d₃ (hydrochloride))

Other Forms of Phenylephrine-2,4,6-d₃ hydrochloride:

Phenylephrine-2,4,6-d₃ hydrochloride Related Antibodies

Phenylephrine-2,4,6-d₃ hydrochloride Related Antibodies

Phenylephrine-2,4,6-d₃ hydrochloride Related Classifications