2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Pralidoxime iodide

Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.

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Pralidoxime iodide Chemical Structure

Pralidoxime iodide Chemical Structure

CAS No. : 94-63-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in DMSO USD 28 In-stock
Solid
25 mg USD 25 In-stock
100 mg USD 37 In-stock
250 mg USD 49 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pralidoxime iodide:

Pralidoxime iodide Related Antibodies

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Description

Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].

IC50 & Target

AChE

 

In Vivo

Pralidoxime iodide (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3]
Dosage: 10, 50, 100 and 150 mg/kg
Administration: Intramuscularly, once
Result: Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
Clinical Trial
Molecular Weight

264.06

Formula

C7H9IN2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[N+]1=CC=CC=C1/C=N/O.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (946.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7870 mL 18.9351 mL 37.8702 mL
5 mM 0.7574 mL 3.7870 mL 7.5740 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7870 mL 18.9351 mL 37.8702 mL 94.6755 mL
5 mM 0.7574 mL 3.7870 mL 7.5740 mL 18.9351 mL
10 mM 0.3787 mL 1.8935 mL 3.7870 mL 9.4675 mL
15 mM 0.2525 mL 1.2623 mL 2.5247 mL 6.3117 mL
20 mM 0.1894 mL 0.9468 mL 1.8935 mL 4.7338 mL
25 mM 0.1515 mL 0.7574 mL 1.5148 mL 3.7870 mL
30 mM 0.1262 mL 0.6312 mL 1.2623 mL 3.1558 mL
40 mM 0.0947 mL 0.4734 mL 0.9468 mL 2.3669 mL
50 mM 0.0757 mL 0.3787 mL 0.7574 mL 1.8935 mL
60 mM 0.0631 mL 0.3156 mL 0.6312 mL 1.5779 mL
80 mM 0.0473 mL 0.2367 mL 0.4734 mL 1.1834 mL
100 mM 0.0379 mL 0.1894 mL 0.3787 mL 0.9468 mL
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Pralidoxime iodide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pralidoxime94-63-3Cholinesterase (ChE)respiratorytoxicitynerveantidoteorganophosphatepoisoningInhibitorinhibitorinhibit

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