Pramipexole dihydrochloride

Name: Pramipexole dihydrochloride
Brand: MedChemExpress
SKU: HY-17355
Rating: 5.0 (5 reviews)

Cat. No.: HY-17355 Purity: 99.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

For research use only. We do not sell to patients.

Pramipexole dihydrochloride Chemical Structure

CAS No. : 104632-25-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 138	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Pramipexole dihydrochloride:

Dexpramipexole dihydrochloride In-stock
Dexpramipexole Get quote
Pramipexole-d₇ dihydrochloride Get quote
Pramipexole-d₅ dihydrochloride Get quote
Pramipexole-d₇-1 dihydrochloride Get quote
Pramipexole Get quote
Pramipexole dihydrochloride hydrate Get quote

5 Publications Citing Use of MCE Pramipexole dihydrochloride

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•Related Screening Libraries:

•Related Small Molecules:

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View All Dopamine Receptor Isoform Specific Products:

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

D₂ Receptor

D₃ Receptor

D₄ Receptor

In Vitro

Pramipexole shows a low binding affinity for D1-type receptor, with an IC₅₀ of >50,000 nM^[1].
Pramipexole dihydrochloride (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size^[3].
Pramipexole dihydrochloride attenuates levodopa-induced toxicity in mesencephalic cultures, suggests that pramipexole may be cytoprotective to dopamine neurons in tissue culture^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pramipexole dihydrochloride (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals^[5].
Pramipexole dihydrochloride improves neurological recovery^[5].
Pramipexole dihydrochloride prevents ischemic cell death via mitochondrial pathways in ischemic stroke^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 250-300 g (16-18 weeks old)^[5]
Dosage:	0.25 mg/kg, 1 mg/kg
Administration:	Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion
Result:	Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.

Clinical Trial

Molecular Weight

284.25

Formula

C₁₀H₁₉Cl₂N₃S

CAS No.

104632-25-9

Appearance

Solid

Color

White to off-white

SMILES

NC(S1)=NC2=C1C[C@@H](NCCC)CC2.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (615.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (175.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5180 mL	17.5902 mL	35.1803 mL
5 mM	0.7036 mL	3.5180 mL	7.0361 mL
10 mM	0.3518 mL	1.7590 mL	3.5180 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (351.80 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (246 KB) HNMR (247 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78. [Content Brief]

[2]. Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71. [Content Brief]

[3]. Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018; 2018: 4196961. [Content Brief]

[4]. P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28. [Content Brief]

[5]. Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12(8): dmm033860. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.5180 mL	17.5901 mL	35.1803 mL	87.9507 mL
	5 mM	0.7036 mL	3.5180 mL	7.0361 mL	17.5901 mL
	10 mM	0.3518 mL	1.7590 mL	3.5180 mL	8.7951 mL
	15 mM	0.2345 mL	1.1727 mL	2.3454 mL	5.8634 mL
	20 mM	0.1759 mL	0.8795 mL	1.7590 mL	4.3975 mL
	25 mM	0.1407 mL	0.7036 mL	1.4072 mL	3.5180 mL
	30 mM	0.1173 mL	0.5863 mL	1.1727 mL	2.9317 mL
	40 mM	0.0880 mL	0.4398 mL	0.8795 mL	2.1988 mL
	50 mM	0.0704 mL	0.3518 mL	0.7036 mL	1.7590 mL
	60 mM	0.0586 mL	0.2932 mL	0.5863 mL	1.4658 mL
	80 mM	0.0440 mL	0.2199 mL	0.4398 mL	1.0994 mL
	100 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.8795 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.