2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. PROTAC ERα Degrader-6

PROTAC ERα Degrader-6 (compound A3) is a potent PROTAC degrader of ERα, with DC50 of 0.12 μM. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation.

For research use only. We do not sell to patients.

PROTAC ERα Degrader-6 Chemical Structure

PROTAC ERα Degrader-6 Chemical Structure

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1 mg USD 515 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
5 mg USD 1130 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
10 mg USD 1808 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
25 mg USD 3800 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks
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Customer Review

Based on 1 publication(s) in Google Scholar

PROTAC ERα Degrader-6 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC ERα Degrader-6 (compound A3) is a potent PROTAC degrader of ERα, with DC50 of 0.12 μM. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation[1].

IC50 & Target

ERα

0.12 μM (DC50)

In Vitro

PROTAC ERα Degrader-6 (compound A3) displays exceptional anti-proliferative activity against MCF-7 cells (IC50=0.051 μM)[1].
PROTAC ERα Degrader-6 exhibits exceptional fluorescence imaging performance with λ = 582 nm, a Stokes shift of 116 nm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC ERα Degrader-6 Related Antibodies
Molecular Weight

913.09

Formula

C51H56N6O8S
SMILES

O=C(N1C[C@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@@H](NC(CCCCCCCOC4=C(C=CC(O)=C4)/C=C/C5=C/C(C6=CC(O)=CC=C6O5)=C(C#N)/C#N)=O)C(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC ERα Degrader-6 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ERα Degrader-6PROTAC ERα Degrader6PROTAC ERα Degrader 6PROTACsEstrogen Receptor/ERRMCF-7 cellreal-time visualizationfluorescent probesInhibitorinhibitorinhibit

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