2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. PROTAC ERα Degrader-6

PROTAC ERα Degrader-6 (compound A2) is a potent PROTAC degrader of ERα, with IC50 of 0.11 μM in MCE-7 cells. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation.

For research use only. We do not sell to patients.

PROTAC ERα Degrader-6 Chemical Structure

PROTAC ERα Degrader-6 Chemical Structure

Size Price Stock Quantity
1 mg USD 515 In-stock
5 mg USD 1130 In-stock
10 mg USD 1808 In-stock
25 mg USD 3800 Get quote
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

PROTAC ERα Degrader-6 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC ERα Degrader-6 (compound A2) is a potent PROTAC degrader of ERα, with IC50 of 0.11 μM in MCE-7 cells. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation[1].

IC50 & Target

ERα

0.12 μM (DC50)

In Vitro

PROTAC ERα Degrader-6 (compound A2) displays exceptional anti-proliferative activity against MCF-7 cells (IC50=0.11 μM)[1].
PROTAC ERα Degrader-6 exhibits exceptional fluorescence imaging performance with λ = 582 nm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC ERα Degrader-6 Related Antibodies
Molecular Weight

913.09

Formula

C51H56N6O8S
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C(N1C[C@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@@H](NC(CCCCCCCOC4=C(C=CC(O)=C4)/C=C/C5=C/C(C6=CC(O)=CC=C6O5)=C(C#N)/C#N)=O)C(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (54.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0952 mL 5.4759 mL 10.9518 mL
5 mM 0.2190 mL 1.0952 mL 2.1904 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0952 mL 5.4759 mL 10.9518 mL 27.3796 mL
5 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4759 mL
10 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7380 mL
15 mM 0.0730 mL 0.3651 mL 0.7301 mL 1.8253 mL
20 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3690 mL
25 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL
30 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9127 mL
40 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6845 mL
50 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5476 mL
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PROTAC ERα Degrader-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ERα Degrader-6PROTAC ERα Degrader6PROTAC ERα Degrader 6PROTACsEstrogen Receptor/ERRMCF-7 cellreal-time visualizationfluorescent probesInhibitorinhibitorinhibit

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