2. MAPK/ERK Pathway
  3. Raf
  4. Raf inhibitor 2

Raf inhibitor 2 is a potent raf kinase (IC50<1.0 μM) inhibitor, compound 32, extracted from patent EP1003721B1. Raf inhibitor 2 can be used for cancer research.

For research use only. We do not sell to patients.

Raf inhibitor 2 Chemical Structure

Raf inhibitor 2 Chemical Structure

CAS No. : 220904-99-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 127 In-stock
Solution
10 mM * 1 mL in DMSO USD 127 In-stock
Solid
5 mg USD 115 In-stock
10 mg USD 180 In-stock
25 mg USD 340 In-stock
50 mg USD 510 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Raf inhibitor 2 Related Antibodies

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Description

Raf inhibitor 2 is a potent raf kinase (IC50<1.0 μM) inhibitor, compound 32, extracted from patent EP1003721B1. Raf inhibitor 2 can be used for cancer research[1].

Cellular Effect
Cell Line Type Value Description References
H4 IC50
15 μM
Compound: 16k
Inhibition of gamma secretase in human H4 cells expressing APP695 assessed as inhibition of Abeta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Inhibition of gamma secretase in human H4 cells expressing APP695 assessed as inhibition of Abeta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
[PMID: 23107479]
Molecular Weight

429.49

Formula

C15H8Br2ClNO2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3283 mL 11.6417 mL 23.2834 mL
5 mM 0.4657 mL 2.3283 mL 4.6567 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3283 mL 11.6417 mL 23.2834 mL 58.2086 mL
5 mM 0.4657 mL 2.3283 mL 4.6567 mL 11.6417 mL
10 mM 0.2328 mL 1.1642 mL 2.3283 mL 5.8209 mL
15 mM 0.1552 mL 0.7761 mL 1.5522 mL 3.8806 mL
20 mM 0.1164 mL 0.5821 mL 1.1642 mL 2.9104 mL
25 mM 0.0931 mL 0.4657 mL 0.9313 mL 2.3283 mL
30 mM 0.0776 mL 0.3881 mL 0.7761 mL 1.9403 mL
40 mM 0.0582 mL 0.2910 mL 0.5821 mL 1.4552 mL
50 mM 0.0466 mL 0.2328 mL 0.4657 mL 1.1642 mL
60 mM 0.0388 mL 0.1940 mL 0.3881 mL 0.9701 mL
80 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7276 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.5821 mL
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Raf inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raf inhibitor 2220904-99-4Raf inhibitor2Raf inhibitor-2RafRaf kinasescancerInhibitorinhibitorinhibit

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