2. Metabolic Enzyme/Protease
  3. Oxidative Phosphorylation Mitochondrial Metabolism
  4. S3QEL-2

S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation.

For research use only. We do not sell to patients.

S3QEL-2 Chemical Structure

S3QEL-2 Chemical Structure

CAS No. : 890888-12-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 70 In-stock
50 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

S3QEL-2 Related Antibodies

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  • Purity & Documentation

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Description

S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation[1].

In Vitro

S3QELs-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells and S3QEL-2 strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S3QEL-2 Related Antibodies
Molecular Weight

323.44

Formula

C19H25N5
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

CCCN(CCC)C1=C2C(N(C3=CC=C(C)C(C)=C3)N=C2)=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (64.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0918 mL 15.4588 mL 30.9176 mL
5 mM 0.6184 mL 3.0918 mL 6.1835 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.54%

COA (255 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0918 mL 15.4588 mL 30.9176 mL 77.2941 mL
5 mM 0.6184 mL 3.0918 mL 6.1835 mL 15.4588 mL
10 mM 0.3092 mL 1.5459 mL 3.0918 mL 7.7294 mL
15 mM 0.2061 mL 1.0306 mL 2.0612 mL 5.1529 mL
20 mM 0.1546 mL 0.7729 mL 1.5459 mL 3.8647 mL
25 mM 0.1237 mL 0.6184 mL 1.2367 mL 3.0918 mL
30 mM 0.1031 mL 0.5153 mL 1.0306 mL 2.5765 mL
40 mM 0.0773 mL 0.3865 mL 0.7729 mL 1.9324 mL
50 mM 0.0618 mL 0.3092 mL 0.6184 mL 1.5459 mL
60 mM 0.0515 mL 0.2576 mL 0.5153 mL 1.2882 mL
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S3QEL-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S3QEL-2890888-12-7Oxidative PhosphorylationMitochondrial MetabolismsuperoxideproductionmitochondrialcomplexIIIoxidativephosphorylationelectronfluxInhibitorinhibitorinhibit

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