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Results for "

α2-adrenergic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (65) 5-HT Receptor (10) Adenosine Receptor (1) Dopamine Receptor (4) Drug Metabolite (2) Endogenous Metabolite (5) GnRH Receptor (2) Imidazoline Receptor (1) Isotope-Labeled Compounds (4) Phosphatase (2) Potassium Channel (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (17) Endocrinology (32) Infection (2) Inflammation/Immunology (2) Metabolic Disease (6) Neurological Disease (45)

Inhibitors & Agonists

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Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Adrenergic Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0194A

Tizanidine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

HY-B0194

Tizanidine	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

HY-105960A

Fenmetozole hydrochloride	Adrenergic Receptor	Neurological Disease
Fenmetozole hydrochloride is an antagonist of ethanol, and also antagonizes α2-adrenergic receptor, which has antidepressant effect .

HY-112074

Tiamenidine HOE 440	Adrenergic Receptor	Cardiovascular Disease
Tiamenidine (HOE 440) is an orally active *α2-adrenergic* receptor** agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research .

HY-135895

Detomidine carboxylic acid	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic *α2-adrenergic* agonist. Detomidine also has cardiac and respiratory effects and an antidiuretic action ^[2].

HY-106444A

Fipamezole hydrochloride MPV-1730 hydrochloride; JP-1730 hydrochloride	Adrenergic Receptor	Neurological Disease
Fipamezole hydrochloride is a potent and orally active *α2-adrenergic* receptor antagonist with K_i** values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C, receptors, respectively. Fipamezole hydrochloride is an anti-dyskinetic agent, and can be used for the study of Parkinson's disease .

HY-106444

Fipamezole MPV 1730; JP-1730	Adrenergic Receptor	Neurological Disease
Fipamezole (MPV 1730; JP-1730) is a potent and orally active *α2-adrenergic* receptor antagonist with K_i** values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C, receptors, respectively. Fipamezole is an anti-dyskinetic agent, and can be used for the study of Parkinson's disease .

HY-106874

Delequamine RS-15385-197	Adrenergic Receptor	Neurological Disease
Delequamine (RS-15385-197) is an orally active and selective *α2-adrenergic* receptor antagonist with a pK_i** of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction .

HY-106874A

Delequamine hydrochloride RS-15385-197 hydrochloride	Adrenergic Receptor	Neurological Disease
Delequamine (RS-15385-197) hydrochloride is an orally active and selective *α2-adrenergic* receptor antagonist with a pK_i** of 9.5 for α2-adrenoceptors in rat cortex. Delequamine hydrochloride shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride can be used for the study of erectile dysfunction .

HY-106617A

Etoperidone hydrochloride	5-HT Receptor Adrenergic Receptor	Neurological Disease
Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows K_d values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively ^[2].

HY-U00402

Fenmetozole Tosylate	Adrenergic Receptor	Neurological Disease Endocrinology
Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes *α2-adrenergic* receptor**, and acts as an antidepressant agent.

HY-107358A

Lidamidine hydrochloride WHR-1142A	Adrenergic Receptor	Others
Lidamidine hydrochloride (WHR-1142A) is an *α2-adrenergic* receptor agonist and antidiarrheal agent .

HY-105960

Fenmetozole	Adrenergic Receptor	Cardiovascular Disease
Fenmetozole is an antagonist of ethanol, and also antagonizes *α2-adrenergic* receptor**, which has antidepressant effect .

HY-U00371

AR-08	Adrenergic Receptor	Neurological Disease Endocrinology
AR-08 is an agonist of *α2-adrenergic* receptor**, used for the treatment of attention deficit hyperactivety disorder (ADHD).

HY-107358

Lidamidine WHR-1142A free base	Adrenergic Receptor	Metabolic Disease
Lidamidine (WHR-1142A free base) is an *α2-adrenergic* receptor agonist and antidiarrheal agent .

HY-B0163

Detomidine	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine, an imidazole derivative, is a potent *α2-adrenergic* agonist. Detomidine produces dose-dependent analgesic effects ^[2].

HY-B0163A

Detomidine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine hydrochloride, an imidazole derivative, is a potent *α2-adrenergic* agonist. Detomidine hydrochloride produces dose-dependent analgesic effects ^[2].

HY-B0659

Brimonidine 3 Publications Verification UK 14304; AGN190342	Adrenergic Receptor	Endocrinology Cancer
Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0659A

Brimonidine tartrate 3 Publications Verification UK 14304 tartrate; AGN190342 tartrate	Adrenergic Receptor	Endocrinology Cancer
Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-129697

3-Hydroxy Medetomidine 3-OH Medetomidine; Medetomidine metabolite MIII	Others	Metabolic Disease
3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.

HY-B0194S

Tizanidine-d4	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2].

HY-B0659S

Brimonidine-d4	Adrenergic Receptor	Endocrinology
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-12721

Clonidine 5 Publications Verification	Adrenergic Receptor	Neurological Disease Cancer
Clonidine is an *alpha 2-adrenergic* agonist .

HY-B0659R

Brimonidine (Standard)	Adrenergic Receptor	Endocrinology Cancer
Brimonidine (Standard) is the analytical standard of Brimonidine. This product is intended for research and analytical applications. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0163AR

Detomidine hydrochloride (Standard)	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine (hydrochloride) (Standard) is the analytical standard of Detomidine (hydrochloride). This product is intended for research and analytical applications. Detomidine hydrochloride, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine hydrochloride produces dose-dependent analgesic effects ^[2].

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-112658

p-Iodoclonidine hydrochloride	Adrenergic Receptor Adenosine Receptor	Endocrinology
p-Iodoclonidine hydrochloride is a partial agonist of *α2-adrenergic* receptor**. p-Iodoclonidine hydrochloride also has minimal agonist activity in inhibiting adenylate cyclase in platelet membranes, and potentiates ADP induced platelet aggregation with an EC₅₀ of 1.5 μM .

HY-B0659AR

Brimonidine tartrate (Standard)	Adrenergic Receptor	Endocrinology Cancer
Brimonidine (tartrate) (Standard) is the analytical standard of Brimonidine (tartrate). This product is intended for research and analytical applications. Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-101610

OPC-28326	Adrenergic Receptor	Cardiovascular Disease Endocrinology
OPC-28326 is a selective peripheral vasodilator and an angatonist of *α2-adrenergic* receptor, with K_i** of 2040, 285, and 55?nM for α2A-, α2B- and α2C-adrenoceptors, respectively.

HY-B1696A

Methyldopate hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Methyldopate hydrochloride is an ethyl ester hydrochloride proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate hydrochloride has the potential for severe hypertension research .

HY-B1696

Methyldopate	Adrenergic Receptor	Cardiovascular Disease
Methyldopate is an ethyl ester proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research .

HY-19057

Vatinoxan MK-467; L-659066	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Vatinoxan (MK-467) is an alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan determines that it has limited penetration across the blood-brain barrier and therefore has low concentrations in the central nervous system. Vatinoxan antagonizes alpha 2-adrenergic receptor receptors by binding to them, thereby reducing or preventing cardiovascular effects caused by α2-adrenergic agonists. Vatinoxan can be used in studies of cardiovascular effects, sedation and analgesia .

HY-B0225AS

Methyldopa-d3 hydrochloride L-(-)-α-Methyldopa-d₃ hydrochloride; MK-351-d₃ hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

HY-12721R

Clonidine (Standard)	Adrenergic Receptor	Neurological Disease Cancer
Clonidine (Standard) is the analytical standard of Clonidine. This product is intended for research and analytical applications. Clonidine is an *alpha 2-adrenergic* agonist .

HY-111022

Icerguastat Sephin1; IFB-088	Phosphatase	Infection Inflammation/Immunology
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect ^[2] .

HY-B0225BR

Methyldopa hydrate (Standard)	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-136693

L-654284	Others	Neurological Disease
L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows K_i values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a K_i of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system .

HY-110365

Icerguastat Carbonate Sephin1 Carbonate; IFB-088 Carbonate	Phosphatase	Infection
Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect ^[2] .

HY-14607

Besipirdine hydrochloride HP 749	Potassium Channel	Neurological Disease
Besipirdine (hydrochloride) is a potassium channel blocker with cholinergic and adrenergic activity. The cholinergic activity of Besipirdine (hydrochloride) involves stimulating phosphatidylinositol turnover and reducing potassium currents. The adrenergic activity of Besipirdine (hydrochloride) involves stimulating norepinephrine release, which is attributed to the inhibition of presynaptic α2-adrenergic receptors and the inhibition of norepinephrine uptake. Besipirdine (hydrochloride) may be used in research for Alzheimer's disease .

HY-103413

Eticlopride hydrochloride	Dopamine Receptor	Neurological Disease
Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with K_is of 0.09, 112, 699, 6220, and 830 nM, respectively. Antipsychotic agent .

HY-12706

Spiroxatrine R 5188	Adrenergic Receptor 5-HT Receptor	Neurological Disease Inflammation/Immunology
Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and *α2-adrenergic, with the K_i* values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and *5-HT2*, respectively. Spiroxatrine (R 5188) has a sedative effect ^[2] .

HY-32329

Setiptiline Org-8282	5-HT Receptor Adrenergic Receptor	Neurological Disease
Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research ^[2] .

HY-32329A

Setiptiline maleate MO-8282	5-HT Receptor	Neurological Disease
Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT_2A, 5-HT_2C, and/or 5-HT₃ subtypes, as well as an H1 receptor inverse agonist/antihistamine ^[2] .

HY-162620

α2A-AR agonist 1	Adrenergic Receptor	Cancer
α2A-AR agonist 1 (Compound B9) is a selective agonist for *α2-adrenergic* receptor** (α2A-AR) with EC₅₀ of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED₅₀ of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes .

HY-32329S

Setiptiline-d3	Isotope-Labeled Compounds 5-HT Receptor Adrenergic Receptor	Neurological Disease
Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].

HY-P3641A

Kisspeptin 13 TFA	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research ^[2] .

HY-A0139

Thiothixene NSC 108165; Navan; Navane	Others	Others
Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

Cat. No.	Product Name	Target	Research Area

HY-P3641A

Kisspeptin 13 TFA	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research ^[2] .

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research ^[2] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Hippocastanaceae Source classification Aesculus hippocastanum Plants Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-A0019

Paliperidone 2 Publications Verification 9-Hydroxyrisperidone	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and *5-HT2A* antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-B0163

Detomidine	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Detomidine, an imidazole derivative, is a potent *α2-adrenergic* agonist. Detomidine produces dose-dependent analgesic effects ^[2].

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-B0225BR

Methyldopa hydrate (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system ^[2].

HY-12710A

Rauwolscine hydrochloride α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride	Alkaloids other families Classification of Application Fields Neurological Disease Source classification Plants Disease Research Fields Endocrinology Indole Alkaloids	Adrenergic Receptor
Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a K_i of 12 nM.

HY-A0019R

Paliperidone (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and *5-HT2A* antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

Cat. No.	Compare	Product Name	Species	Source

HY-P702203

	ADRA2A-VLPs Protein, Human (HEK293, His) Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR	Human	HEK293
	ADRA2A-VLPs Protein, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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Cat. No.	Product Name	Chemical Structure

HY-B0194S

Tizanidine-d4
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2].

HY-12715S

Yohimbine-13C,d3
Yohimbine- ¹³C,d₃ is the ¹³C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

HY-B0659S

Brimonidine-d4
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0225AS

Methyldopa-d3 hydrochloride
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].

HY-12721S

Clonidine-d4 hydrochloride
Clonidine-d₄ (hydrochloride) is the deuterium labeled Clonidine. Clonidine hydrochloride is an alpha 2-adrenergic agonist[1].

HY-12717AS

Phentolamine-d4 hydrochloride

Phentolamine-d₄ (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].

HY-A0019S

Paliperidone-d4
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].

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