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Results for "

14.18

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (5) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (1) Autophagy (1) Bacterial (5) Beta-lactamase (4) Biochemical Assay Reagents (1) CD2 (1) Dihydrofolate reductase (DHFR) (1) Dopamine Receptor (2) EGFR (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) Fluorescent Dye (1) Fungal (1) HIF/HIF Prolyl-Hydroxylase (1) IKK (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Kinesin (1) Mitophagy (1) Penicillin-binding protein (PBP) (1) Sirtuin (1) Thyroid Hormone Receptor (2) Tyrosinase (1)
By Research Areas:	Cancer (11) Endocrinology (3) Infection (5) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)

By Targets:

Antibiotic (5)

Antibody-Drug Conjugates (ADCs) (1)

Apoptosis (1)

Autophagy (1)

Bacterial (5)

Beta-lactamase (4)

Biochemical Assay Reagents (1)

CD2 (1)

Dihydrofolate reductase (DHFR) (1)

Dopamine Receptor (2)

EGFR (1)

Endogenous Metabolite (1)

Estrogen Receptor/ERR (1)

Fluorescent Dye (1)

Fungal (1)

HIF/HIF Prolyl-Hydroxylase (1)

IKK (1)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (1)

Kinesin (1)

Mitophagy (1)

Penicillin-binding protein (PBP) (1)

Sirtuin (1)

Thyroid Hormone Receptor (2)

Tyrosinase (1)

By Research Areas:

Cancer (11)

Endocrinology (3)

Infection (5)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1418A

DPC-AJ1951 TFA	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951 TFA, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 TFA in ex vivo and in vivo assays of bone resorption .

HY-B1418

Tazobactam 10+ Cited Publications CL-298741; YTR-830H	Beta-lactamase Antibiotic Bacterial	Infection Cancer
Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-N1418

(S)-(-)-Tetrahydroberberine (-)-Canadine; (S)-(-)-Canadine	Others	Inflammation/Immunology
(S)-(-)-Tetrahydroberberine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity .

HY-42849A

Sultopride hydrochloride 1 Publications Verification LIN-1418 hydrochloride	Dopamine Receptor	Neurological Disease
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.

HY-N1418A

(R)-(+)-Tetrahydroberberine (+)-Canadine; (R)-(+)-Canadine	Others	Inflammation/Immunology
(R)-(+)-Tetrahydroberberine is the isomer of (S)-(-)-Tetrahydroberberine (HY-N1418), and can be used as an experimental control. (S)-(-)-Tetrahydroberberine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity .

HY-P1418

DPC-AJ1951	Thyroid Hormone Receptor	Endocrinology
DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 in ex vivo and in vivo assays of bone resorption .

HY-B1418R

Tazobactam (Standard)	Beta-lactamase Antibiotic Bacterial	Infection
Tazobactam (Standard) is the analytical standard of Tazobactam. This product is intended for research and analytical applications. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-B1418S2

Tazobactam-15N,d2 CL-298741-¹⁵N_{,d₂; YTR-830H-¹⁵N_,d₂}	Isotope-Labeled Compounds Bacterial Antibiotic Beta-lactamase	Infection Cancer
Tazobactam- ¹⁵N,d₂ (CL-298741- ¹⁵N,d₂) is ¹⁵N and deuterium labeled Tazobactam. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-D1418

CP-BP-SFAC	Fluorescent Dye	Others
CP-BP-SFAC is a luminogenic molecule. CP-BP-SFAC exhibits strong sky-blue delayed fluorescence in neat films .

HY-42849

Sultopride LIN-1418	Dopamine Receptor	Neurological Disease
Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.

HY-W585442

*5,9,14,18,23,27,32,36-Octabutoxy-2,3-naphthalocyanine*	Biochemical Assay Reagents Endogenous Metabolite
5,9,14,18,23,27,32,36-Octabutoxy-2,3-naphthalocyanine is a photosensitive material with excellent light absorption and electron conduction activity. 5,9,14,18,23,27,32,36-Octabutoxy-2,3-naphthalocyanine is widely used in optoelectronic devices and is considered to be an effective photocatalyst. 5,9,14,18,23,27,32,36-Octabutoxy-2,3-naphthalocyanine can be used to improve the performance of solar cells and increase the photoelectric conversion efficiency. 5,9,14,18,23,27,32,36-Octabutoxy-2,3-naphthalocyanine also has potential anti-tumor activity and can inhibit the proliferation of certain cancer cells. 5,9,14,18,23,27,32,36-Octabutoxy-2,3-naphthalocyanine exhibits excellent fluorescence properties in medical imaging, which helps to improve the clarity and accuracy of imaging. 5,9,14,18,23,27,32,36-Octabutoxy-2,3-naphthalocyanine is studied as a component of a novel compound delivery system to improve the targeting and release effect of the compound.

HY-158109

M3554	Antibody-Drug Conjugates (ADCs) CD2	Cancer
M3554 is a novel anti-GD2 ADC designed based on humanized ch14.18 anti-GD2 antibody and has anti-tumor activity. The cytotoxicity of M3554 against the GD2-positive neuroblastoma cell line CHP134 was in the subnanomolar IC₅₀ range.

HY-B1923A

Piperacillin hydrate Pipracil hydrate	Antibiotic Bacterial Beta-lactamase Penicillin-binding protein (PBP)	Infection Cancer
Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418) .

HY-149632

EGFR/HER2/DHFR-IN-2	EGFR Dihydrofolate reductase (DHFR)	Cancer
EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC₅₀: 0.248, 0.156, 0.138 μM respectively). EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC₅₀: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 μM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells). EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth .

HY-164978

KIF18A-IN-14	Kinesin	Cancer
KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. KIF18A-IN-14 is available in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cells viability with IC₅₀s of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor (e.g. colon, breast, lung) studies .

HY-163601

HIF-2α-IN-14	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-2α-IN-14 (18) is a HIF-2α inhibitor, with an IC₅₀ of 0.27 μM .

HY-125860

Tyrosinase, Mushroom Polyphenol oxidase	Tyrosinase	Neurological Disease Endocrinology Cancer
Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes. Tyrosinase can be used in research on Parkinson's disease, melanoma and pigmentation .

HY-D0272

2,3,4-Trihydroxybenzophenone	Estrogen Receptor/ERR	Metabolic Disease
2,3,4-Trihydroxybenzophenone is a hydroxylated benzophenone UV filter with estrogenic activity. 2,3,4-Trihydroxybenzophenone is also a redox mediator, which has a role as a quorum sensing inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, a human urinary metabolite, a rat metabolite and a drug metabolite .

HY-16561

Resveratrol Maximum Cited Publications 108 Publications Verification trans-Resveratrol; SRT501	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Type