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4.13

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (1) Adrenergic Receptor (1) Apoptosis (5) Autophagy (4) Biochemical Assay Reagents (1) Btk (1) Calcium Channel (1) CDK (3) Discoidin Domain Receptor (2) DNA/RNA Synthesis (3) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (15) FGFR (1) Fluorescent Dye (1) GABA Receptor (1) HDAC (1) HSP (2) IRAK (1) Isotope-Labeled Compounds (22) Ligands for Target Protein for PROTAC (1) LXR (1) mAChR (1) MDM-2/p53 (1) MicroRNA (1) Microtubule/Tubulin (2) MMP (1) Neprilysin (1) PI3K (1) PKC (1) Progesterone Receptor (1) PROTAC Linkers (3) PROTACs (1) Reactive Oxygen Species (1) RSV (1) SARS-CoV (2) Thyroid Hormone Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (4) TSH Receptor (1)
By Research Areas:	Cancer (30) Cardiovascular Disease (3) Endocrinology (4) Infection (5) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (6)
Click Chemistry:	PROTAC Synthesis (1) Azide (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153368

Zomiradomide KT-413	IRAK PROTACs	Cancer
KT-413 (example I-3) is an orally active PROTAC-class IRAK degrader . KT-413 consists of a target protein ligand (red part) PROTAC IRAK4 ligand-5 (HY-168311), an E3 ubiquitin ligase ligand (blue part) Thalidomide-4-Br (HY-W039116), and a PROTAC linker (black part) 2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine (HY-168313). E3 ubiquitin ligase and linker can form Thalidomide-NH-C2-2-azaspiro[3.3]heptane (HY-168312). The active control for the target protein ligand is RSL3-4-Me (HY-169375).

HY-15260

XL413 4 Publications Verification BMS-863233	CDK	Cancer
XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-15260A

XL413 monohydrochloride 4 Publications Verification BMS-863233 monohydrochloride	CDK	Cancer
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-116956S3

*D-Erythrose-4-13C*	Isotope-Labeled Compounds	Others
D-Erythrose-4- ¹³C is the ¹³C labeled D-Erythrose[1].

HY-N0473S5

*L-Tyrosine-4-13C*	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Tyrosine-4- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-159678

4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate	PROTAC Linkers	Cancer
4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate is a PROTAC Linker. 4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate can be used in the synthesis of PROTAC SMARCA2/4-degrader-27 (HY-162834) .

HY-111781

Civorebrutinib WS-413	Btk	Cancer
Civorebrutinib (WS-413) is a Bruton's tyrosine kinase inhibitor with antineoplastic effect .

HY-15260C

XL413 hydrochloride BMS-863233 hydrochloride	CDK	Cancer
XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC₅₀=3.4 nM). XL413 hydrochloride has favorable pharmacokinetic profiles and significantly inhibits tumor growth in rodent models. XL413 hydrochloride can be used in cancer research .

HY-146465

Anticancer agent 60	Microtubule/Tubulin	Cancer
Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC₅₀ = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .

HY-168313

2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine	PROTAC Linkers	Others
2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine is the PROTAC linker of KT-413 (HY-153368) and can be used in the synthesis of PROTACs .

HY-168312

Thalidomide-NH-C2-2-azaspiro[3.3]heptane	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-NH-C2-2-azaspiro[3.3]heptane is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of KT-413 (HY-153368) .

HY-168311

PROTAC IRAK4 ligand-5	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368) .

HY-W127841

*Citric acid-2,4-13C2*	Biochemical Assay Reagents	Others
Citric acid-2,4-13C2 (Sodium Lauryl Sulfate) is a labeled citric acid. Citric acid is found in many fruits and vegetables, especially citrus fruits. It participates in biological processes in the body, such as the citric acid cycle.

HY-N0666S6

*L-Aspartic acid-1,4-13C2*	Endogenous Metabolite	Cardiovascular Disease
L-Aspartic acid-1,4- ¹³C₂ is the ¹³C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

HY-146275

LXRβ agonist-3	LXR	Cancer
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC₅₀ of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC₅₀ of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma .

HY-N6771

Cyclopiazonic acid 4 Publications Verification	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV	Infection
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-140346AS

*L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride*	Isotope-Labeled Compounds PROTAC Linkers	Cancer
L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W017443S4

*L-Asparagine-1,2,3,4-13C4 monohydrate*	Endogenous Metabolite	Metabolic Disease
L-Asparagine-1,2,3,4- ¹³C₄ (monohydrate) is the ¹³C labeled L-Asparagine (monohydrate)[1]. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0666S7

*L-Aspartic acid-1,4-13C2,15N*	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
L-Aspartic acid-1,4- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

HY-N7092S5

*D-Fructose-4-13C* D(-)-Fructose-4-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Others
D-Fructose-4- ¹³C is the ¹³C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].

HY-16562A

Irinotecan hydrochloride Maximum Cited Publications 48 Publications Verification (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413	Topoisomerase Autophagy	Cancer
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-W035051

TSPP tetrasodium	Fluorescent Dye	Infection Cancer
TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm) .

HY-N0537S6

*Xylose-4-13C* D-(+)-Xylose-4-¹³C; (+)-Xylose-4-¹³C; Wood sugar-4-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Others
Xylose-4- ¹³C is the ¹³C labeled Xylose.

HY-N8583

*6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide*	Others	Others
6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide is a Diterpenoids product that can be isolated from the herbs of Polyalthia cheliensis .

HY-N0830S

*Palmitic acid-1,2,3,4-13C4*	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-1,2,3,4- ¹³C₄ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-16562

Irinotecan Maximum Cited Publications 48 Publications Verification (+)-Irinotecan; CPT-11; VAL-413(free base)	Topoisomerase Autophagy	Cancer
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-13979

DDR1-IN-1 3 Publications Verification	Discoidin Domain Receptor	Cancer
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-13979A

DDR1-IN-1 dihydrochloride	Discoidin Domain Receptor	Cancer
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-N0667S4

*L-Asparagine-4-13C monohydrate* (-)-Asparagine-4-¹³C monohydrate; Asn-4-¹³C monohydrate; Asparamide-4-¹³C monohydrate	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Asparagine-4- ¹³C (monohydrate) is the ¹³C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-B2156S1

*Menaquinone-4-13C6* Vitamin K2(MK-4)-¹³C₆; Menaquinone K4-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
Menaquinone-4- ¹³C₆ is the ¹³C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-162900

HSP90-IN-32	HSP	Cancer
HSP90-IN-32 is a Hsp90 C-terminal inhibitor that displays anti-proliferative activities against SKMel173, SKMel103, SKMel19 and A375 cells with IC₅₀ values of 1.01 μM, 0.782 μM, 0.607 μM and 1.413 μM , respectively. HSP90-IN-32 is promising for research of anti-cancer agents .

HY-16562S

Irinotecan-d10 (+)-Irinotecan-d₁₀; CPT-11-d₁₀; VAL-413-d₁₀	Topoisomerase Autophagy	Cancer
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

HY-16562AS

Irinotecan-d5 hydrochloride (+)-Irinotecan-d₅ hydrochloride; CPT-11-d₅ hydrochloride; VAL-413-d₅	Autophagy Topoisomerase Isotope-Labeled Compounds	Cancer
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-143662S

(±)12(13)-DiHOME-d4	Isotope-Labeled Compounds	Others
(±)12(13)-DiHOME-d₄ is the deuterium labeled (±)12(13)-DiHOME[1].

HY-139959S

(±)12(13)-EpOME-d4	Isotope-Labeled Compounds	Others
(±)12(13)-EpOME-d₄ is the deuterium labeled (±)12(13)-EpOME[1].

HY-W009362AS

DL-Isocitric acid-13C4 trisodium hydrate	Isotope-Labeled Compounds	Others
DL-Isocitric acid-13C4 (trisodium hydrate) is a ¹³C labeled DL-Isocitric acid.

HY-107494

13-cis-4-Oxoretinoic acid 4-Keto 13-cis-retinoic acid; 4-Oxoisotretinoin; Ro 22-6595	Endogenous Metabolite	Others
13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .

HY-150625

SARS-CoV-2 nsp13-IN-4	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective nsp13 helicase small-molecule inhibitor and inhibit the ssDNA+ ATPase activity of nsp13 with an IC₅₀ value of 57 μM. SARS-CoV-2 nsp13-IN-4 is agentlike molecule with molecular weight of less than 450Da and can provide a broad-spectrum antiviral effect .

HY-149377

MMP13-IN-4	MMP	Metabolic Disease
MMP13-IN-4 (compound 13) is a potent and selective inhibitor of MMP-13 (IC₅₀=14.6 μM)，involved in osteoarthritis (OA) .

HY-108213S

Inosinic acid-13C10,15N4 dilithium 5'-IMP-¹³C₁₀,¹⁵N₄ dilithium; IMP-¹³C₁₀,¹⁵N₄ dilithium; Inosine 5'-dihydrogen phosphate-¹³C₁₀,¹⁵N₄ dilithium	Isotope-Labeled Compounds	Metabolic Disease
Inosinic acid- ¹³C₁₀, ¹⁵N₄ dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is ¹³C- and ¹⁵N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .

HY-B0084S4

Dienogest-13C,15N,d4 STS 557-¹³C,¹⁵N,d₄	Isotope-Labeled Compounds Progesterone Receptor	Endocrinology
Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-100807S2

Quinolinic acid-13C4,15N	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist and has the potential of mediating NMDA neuronal damage and dysfunction .

HY-12980

Batefenterol GSK961081; TD-5959	Adrenergic Receptor mAChR	Inflammation/Immunology Endocrinology
Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β₂-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ₂-adrenoceptor with K_i values of 1.4, 1.3 and 3.7 nM, respectively.

HY-W017163S

7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9)	Endogenous Metabolite	Metabolic Disease
7-Methylxanthine-2,4,5,6- ¹³C₄, 1,3- ¹⁵N₂ (with variable ¹⁵N labeling at N₉) is the ¹³C and ¹⁵N labeled 7-Methylxanthine[1]. 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi[2].

HY-15407S3

Sacubitril-13C4 AHU-377-¹³C₄	Isotope-Labeled Compounds Neprilysin	Infection
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC₅₀=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .

HY-B0256S1

Azathioprine-13C4 BW 57-322-13C4	Isotope-Labeled Compounds	Others
Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

HY-N0092S3

Inosine-13C10,15N4	Isotope-Labeled Compounds Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine-13C10,15N4 is ¹³C and ¹⁵N labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-18341S4

L-Thyroxine-13C6-1 Levothyroxine-¹³C₆-1; T4-¹³C₆-1	Isotope-Labeled Compounds Endogenous Metabolite Thyroid Hormone Receptor	Endocrinology
L-Thyroxine- ¹³C₆-1 (Levothyroxine- ¹³C₆-1; T4- ¹³C₆-1) is a ¹³C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-B0152S3

Adenine-13C5 6-Aminopurine-¹³C₅; Vitamin B4-¹³C₅	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Adenine- ¹³C₅ (6-Aminopurine- ¹³C₅; Vitamin B4- ¹³C₅) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-59354S1

1,2-Dihydropyridazine-3,6-dione-3,4,5,6-13C4 1,2-Dihydro-3,6-pyridazine-¹³C₄-dione; 3,6-Dihydroxypyridazine-¹³C₄; 3,6-Pyridazine-¹³C₄-diol; Maleic hydrazide-¹³C₄	Isotope-Labeled Compounds DNA/RNA Synthesis	Cancer
1,2-Dihydropyridazine-3,6-dione-3,4,5,6- ¹³C₄ (1,2-Dihydro-3,6-pyridazine- ¹³C₄-dione) is ¹³C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .

Cat. No.	Product Name	Type

HY-W127841

*Citric acid-2,4-13C2*	Biochemical Assay Reagents
Citric acid-2,4-13C2 (Sodium Lauryl Sulfate) is a labeled citric acid. Citric acid is found in many fruits and vegetables, especially citrus fruits. It participates in biological processes in the body, such as the citric acid cycle.

HY-W035051

TSPP tetrasodium	Biochemical Assay Reagents
TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6771

Cyclopiazonic acid 4 Publications Verification	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-16562A

Irinotecan hydrochloride 45+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413	Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	Topoisomerase Autophagy
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-N8583

*6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide*	Structural Classification Terpenoids Source classification Diterpenoids Plants Annonaceae Monoon simiarum (Buch.-Ham. ex Hook. f. & Thomson) B. Xue & R. M. K. Saunders	Others
6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide is a Diterpenoids product that can be isolated from the herbs of Polyalthia cheliensis .

Cat. No.	Compare	Product Name	Species	Source

HY-P79080

	Nodal Protein, Mouse Nodal; Tg.413d	Mouse	E. coli
	Nodal protein plays a key role in embryonic development and is integral for mesoderm formation and axial patterning. Its involvement in these fundamental processes underscores its importance in coordinating the complex series of events that determine early embryonic morphogenesis. Nodal Protein, Mouse is the recombinant mouse-derived Nodal protein, expressed by E. coli , with tag free.

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Cat. No.	Product Name	Chemical Structure

HY-116956S3

*D-Erythrose-4-13C*
D-Erythrose-4- ¹³C is the ¹³C labeled D-Erythrose[1].

HY-N0473S5

*L-Tyrosine-4-13C*
L-Tyrosine-4- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-W127841

*Citric acid-2,4-13C2*
Citric acid-2,4-13C2 (Sodium Lauryl Sulfate) is a labeled citric acid. Citric acid is found in many fruits and vegetables, especially citrus fruits. It participates in biological processes in the body, such as the citric acid cycle.

HY-N0666S6

*L-Aspartic acid-1,4-13C2*
L-Aspartic acid-1,4- ¹³C₂ is the ¹³C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

HY-N7092S5

*D-Fructose-4-13C*
D-Fructose-4- ¹³C is the ¹³C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].

HY-140346AS

L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride

L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W017443S4

*L-Asparagine-1,2,3,4-13C4 monohydrate*
L-Asparagine-1,2,3,4- ¹³C₄ (monohydrate) is the ¹³C labeled L-Asparagine (monohydrate)[1]. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-N0666S7

*L-Aspartic acid-1,4-13C2,15N*
L-Aspartic acid-1,4- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

HY-N0537S6

*Xylose-4-13C*
Xylose-4- ¹³C is the ¹³C labeled Xylose.

HY-N0830S

*Palmitic acid-1,2,3,4-13C4*
Palmitic acid-1,2,3,4- ¹³C₄ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0667S4

*L-Asparagine-4-13C monohydrate*
L-Asparagine-4- ¹³C (monohydrate) is the ¹³C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-B2156S1

*Menaquinone-4-13C6*
Menaquinone-4- ¹³C₆ is the ¹³C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-W750796

Butyric acid-13C4 sodium

Butyric acid-13C4 sodium (Butanoic acid-13C4 sodium) is a stable isotope labeled compound with the activity of promoting cell proliferation and regulating gene expression. Butyric acid-13C4 sodium can be used in metabolic research and compound development to help scientists gain a deeper understanding of the role of short-chain fatty acids in organisms. Butyric acid-13C4 sodium also plays an important role in nutrition and intestinal health research, especially in the regulation of probiotic function and intestinal microbiota.

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

HY-16562AS

Irinotecan-d5 hydrochloride
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-143662S

(±)12(13)-DiHOME-d4
(±)12(13)-DiHOME-d₄ is the deuterium labeled (±)12(13)-DiHOME[1].

HY-139959S

(±)12(13)-EpOME-d4
(±)12(13)-EpOME-d₄ is the deuterium labeled (±)12(13)-EpOME[1].

HY-W009362AS

DL-Isocitric acid-13C4 trisodium hydrate
DL-Isocitric acid-13C4 (trisodium hydrate) is a ¹³C labeled DL-Isocitric acid.

HY-108213S

Inosinic acid-13C10,15N4 dilithium
Inosinic acid- ¹³C₁₀, ¹⁵N₄ dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is ¹³C- and ¹⁵N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-100807S2

Quinolinic acid-13C4,15N
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist and has the potential of mediating NMDA neuronal damage and dysfunction .

HY-W017163S

7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9)
7-Methylxanthine-2,4,5,6- ¹³C₄, 1,3- ¹⁵N₂ (with variable ¹⁵N labeling at N₉) is the ¹³C and ¹⁵N labeled 7-Methylxanthine[1]. 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi[2].

HY-15407S3

Sacubitril-13C4
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC₅₀=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .

HY-B0256S1

Azathioprine-13C4
Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

HY-N0092S3

Inosine-13C10,15N4
Inosine-13C10,15N4 is ¹³C and ¹⁵N labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-18341S4

L-Thyroxine-13C6-1
L-Thyroxine- ¹³C₆-1 (Levothyroxine- ¹³C₆-1; T4- ¹³C₆-1) is a ¹³C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-B0152S3

Adenine-13C5

Adenine- ¹³C₅ (6-Aminopurine- ¹³C₅; Vitamin B4- ¹³C₅) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-59354S1

1,2-Dihydropyridazine-3,6-dione-3,4,5,6-13C4
1,2-Dihydropyridazine-3,6-dione-3,4,5,6- ¹³C₄ (1,2-Dihydro-3,6-pyridazine- ¹³C₄-dione) is ¹³C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .

HY-B0152S2

Adenine-13C5,15N5

Adenine- ¹³C₅,15C5 (6-Aminopurine- ¹³C₅,15C5; Vitamin B4- ¹³C₅,15C5) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

Cat. No.	Product Name		Classification

HY-15843

MIR96-IN-1		Azide
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with K_ds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively . MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140346AS

*L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride*		Azide PROTAC Synthesis
L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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