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Alkylation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (3) Antibiotic (3) Apoptosis (7) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Caspase (1) DNA Alkylator/Crosslinker (10) DNA/RNA Synthesis (3) Endogenous Metabolite (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) MDM-2/p53 (1) nAChR (1) Necroptosis (2) NEKs (2) Nucleoside Antimetabolite/Analog (1) Ras (1) Reactive Oxygen Species (1) Ser/Thr Protease (1) TGF-β Receptor (1)
By Research Areas:	Cancer (22) Infection (2) Inflammation/Immunology (1) Neurological Disease (1)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-34477

2-Iodoacetamide 2 Publications Verification Iodoacetamide	DNA Alkylator/Crosslinker	Others
2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .

HY-107769

Duocarmycin TM 1 Publications Verification CBI-TMI	ADC Cytotoxin DNA Alkylator/Crosslinker Antibiotic	Cancer
Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective *alkylation* of duplex DNA.

HY-Y0694

2',4'-Dihydroxyacetophenone Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone	Endogenous Metabolite	Others
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO₃-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite .

HY-116423

JH295	NEKs	Cancer
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-113306

1-Methyladenine	Endogenous Metabolite	Others
1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

HY-126160

CB10-277	Nucleoside Antimetabolite/Analog DNA Alkylator/Crosslinker	Cancer
CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O ⁶ position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma .

HY-106052

Bofumustine ICIG 1105; NSC 279194; RFCNU	DNA/RNA Synthesis	Cancer
Bofumustine (ICIG 1105) is a nitrosourea compound with antitumor activity. Bofumustine can interfere with the replication and division of tumor cell DNA through alkylation, leading to the death of tumor cells. Bofumustine can be used in the field of cancer research .

HY-10537

Laromustine VNP40101M	DNA/RNA Synthesis	Cancer
Laromustine (VNP40101M) is a compound with antitumor activity. The mechanism of action of Laromustine mainly involves DNA alkylation and DNA repair inhibition. Laromustine can be used for bone marrow transplantation in patients with acute myeloid leukemia and cancer .

HY-116423A

JH295 hydrate	NEKs	Cancer
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160764

N6-Carboxymethyl-ATP	Others	Others
N6-Carboxymethyl-ATP is the alkylation product of ATP with iodoacetic acid at pH 6.5, where alkylation of ATP with iodoacetic acid at pH 6.5 yielded 1-carboxymethyl-ATP which, after alkaline rearrangement gave N6-carboxymethyl-ATP .

HY-112675

4-Octyl itaconate Maximum Cited Publications 50 Publications Verification	Keap1-Nrf2	Inflammation/Immunology
4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 .

HY-101002

Sarcosinamide chloroethylnitrosourea SarCNU; Sarmustine	Apoptosis DNA Alkylator/Crosslinker	Cancer
Sarcosinamide chloroethylnitrosourea is an orally active alkylating agent. Sarcosinamide chloroethylnitrosourea can induce apoptosis by promoting DNA alkylation. Sarcosinamide chloroethylnitrosourea can be used in cancer-related research .

HY-137038

N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride TLCK hydrochloride	Caspase Ser/Thr Protease	Cancer
N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible inhibitor for serine protease, which inhibits trypsin and trypsin-like protease by alkylating histidine residues in their active site. N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride inhibits caspase-3, caspase-6 and caspase-7, with IC₅₀s of 12.0, 54.5 and 19.3 μM, respectively. N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in cell HL-60, and inhibits the decrease in mitochondrial transmembrane potential during apoptosis .

HY-Y0643

Pivaloyloxymethyl chloride Pivaloyloxymethyl chloride	Biochemical Assay Reagents	Others
Pivaloyloxymethyl chloride can be used as electrolyte solvent for lithium batteries, or used as alkylating agent to improve the biomembrane transport of an agent .

HY-34477S1

2-Iodoacetamide-d4 Iodoacetamide-d₄	DNA Alkylator/Crosslinker	Others
2-Iodoacetamide-d₄ is the deuterium labeled 2-Iodoacetamide[1]. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[2][3].

HY-159471

N6-[(6-Aminohexyl)carbamoylmethyl]-ADP	Others	Others
N6-[(6-Aminohexyl)carbamoylmethyl]-ADP is an analog of ADP (HY-W010918), which can be obtained by alkylating ADP .

HY-122493

Illudin M	DNA Alkylator/Crosslinker Apoptosis	Cancer
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities .

HY-112675S

4-Octyl itaconate-13C5-1	Isotope-Labeled Compounds	Others
4-Octyl itaconate- ¹³C₅-1 is ¹³C-labeled 4-Octyl itaconate (HY-112675). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

HY-400705

Duocarmycin SA intermediate-1	Others	Cancer
Duocarmycin SA intermediate-1 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-1 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor-suppressive cytotoxicity with proton irradiation .

HY-400706

Duocarmycin SA intermediate-2	Others	Cancer
Duocarmycin SA intermediate-2 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-2 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor suppressor cytotoxicity with proton irradiation .

HY-13753

Streptozotocin 45+ Cited Publications Streptozocin; NSC-85998; U 9889	DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis	Infection Cancer
Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells .

HY-156843

Antiproliferative agent-38	Others	Cancer
Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .

HY-W741573

N-Biotinyl p-aminophenyl arsenic acid	nAChR	Neurological Disease
N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols. N-Biotinyl p-aminophenyl arsenic acid decreases the Rbungarotoxin-binding sites in reduced Torpedo nicotinic receptors (IC₅₀ is 10-300 nM), and protects the receptor from irreversible alkylation by bromoacetylcholine .

HY-12456

Duocarmycin SA	Antibiotic ADC Cytotoxin DNA Alkylator/Crosslinker Necroptosis Apoptosis	Cancer
Duocarmycin SA is an orally active antitumor antibiotic with an IC₅₀ of 10 pM . Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective *alkylation* of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro .

HY-118810

BIO-013077-01	TGF-β Receptor	Cancer
BIO-013077-01 is a pyrazole TGF-β inhibitor .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .

HY-125098

Illudin S	DNA Alkylator/Crosslinker Apoptosis	Infection Cancer
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-121261

Antineoplastic agent-1	Necroptosis Apoptosis	Cancer
Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research .

HY-155991

RUNX-IN-2	Apoptosis	Cancer
RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity .

HY-129379

DC0-NH2	ADC Cytotoxin	Cancer
DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component .

HY-13641

Mitobronitol Myelobromol; DBM	DNA Alkylator/Crosslinker	Cancer
Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia .

HY-151287

KRAS inhibitor-20	Ras	Cancer
KRAS inhibitor-20 is a small molecular inhibitor of KRas ^G12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRas ^G12C with the IC50 value <10 nM .

Pivaloyloxymethyl chloride Pivaloyloxymethyl chloride	Biochemical Assay Reagents
Pivaloyloxymethyl chloride can be used as electrolyte solvent for lithium batteries, or used as alkylating agent to improve the biomembrane transport of an agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0694

2',4'-Dihydroxyacetophenone Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone	Structural Classification Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO₃-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite .

HY-113306

1-Methyladenine	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

HY-122493

Illudin M	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	DNA Alkylator/Crosslinker Apoptosis
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities .

HY-13753

Streptozotocin 45+ Cited Publications Streptozocin; NSC-85998; U 9889	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis
Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells .

HY-125098

Illudin S	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	DNA Alkylator/Crosslinker Apoptosis
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

Cat. No.	Product Name	Chemical Structure

HY-34477S1

2-Iodoacetamide-d4
2-Iodoacetamide-d₄ is the deuterium labeled 2-Iodoacetamide[1]. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[2][3].

HY-112675S

4-Octyl itaconate-13C5-1
4-Octyl itaconate- ¹³C₅-1 is ¹³C-labeled 4-Octyl itaconate (HY-112675). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Cat. No.	Product Name		Classification

HY-116423

JH295		Alkynes
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116423A

JH295 hydrate		Alkynes
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Alkylation

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products