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Results for "

Aptamer

" in MedChemExpress (MCE) Product Catalog:

47

Inhibitors & Agonists

11

Fluorescent Dye

1

Peptides

1

Isotope-Labeled Compounds

63

Oligonucleotides

Cat. No. Product Name Classification
  • HY-160044
    Apt-M13 aptamer sodium

    		Aptamers
    Apt-M13 aptamer sodium is a mutant 33 nt aptamer based on the original aptamer for dexamethasone (HY-14648). Apt-M13 aptamer sodium can be combined with other nanomaterials for rapid detection of dexamethasone (HY-14648) .
  • HY-160059
    JHIT2e aptamer sodium

    		Aptamers
    JHIT2e aptamer sodium is a molecular probe based on the aptamer JHIT2 of human liver cancer cell line HepG2 cells. JHIT2e aptamer sodiu retains the ability to specifically bind HepG2 and can deliver fluorescent materials or radionuclides to tumors .
  • HY-160045
    AP1153 aptamer sodium

    		Aptamers
    AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo .
  • HY-160066
    SYL3C aptamer sodium

    		Aptamers
    SYL3C aptamer sodium is a DNA aptamer that targets the epithelial cell adhesion molecule (EpCAM) on the surface of cancer cells. SYL3C aptamer sodium targets multiple human cancer cell lines including MDA-MB-231, Kato III, HT-29, T47D and SW480. The Kd of SYL3C aptamer sodium against breast cancer cell line MDA-MB-231 and gastric cancer cell line Kato III is 38 nM and 67 nM, respectively. SYL3C aptamer sodium provides stability, high binding affinity, and selectivity for targeted cancer therapy, cancer cell imaging, and circulating tumor cell detection .
  • HY-160067
    T18.3 aptamer sodium

    		Aptamers
    T18.3 aptamer sodium is an anticoagulant RNA aptamer targeting FV/Va and eliminates the interaction of FV/FVa with phospholipid membranes. T18.3 aptamer sodium exhibits clinically relevant anticoagulant activity in plasma and whole blood and acts synergistically with low molecular weight heparin. The anticoagulant activity of T18.3 aptamer sodium is effectively and rapidly reversed by protamine sulfate .
  • HY-160050
    CD63-1 aptamer sodium

    		Aptamers
    CD63-1 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 38.71 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .
  • HY-160051
    CD63-2 aptamer sodium

    		Aptamers
    CD63-2 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 78.43 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .
  • HY-160053
    Gint4.T aptamer sodium

    		Aptamers
    Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .
  • HY-160043
    AL6 aptamer sodium

    		Aptamers
    AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .
  • HY-160042
    AFP aptamer sodium

    		Aptamers
    AFP aptamer sodium is an aptamer that specifically targets the liver cancer biomarker alpha-fetoprotein (AFP). AFP aptamer sodium can be used as a recognition molecule for AFP, with a linear detection range of 12.5-800 ng/mL .
  • HY-160060
    MA3 aptamer sodium

    		Aptamers
    MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin .
  • HY-160064
    SW1-A aptamer sodium

    		Aptamers
    SW1-A aptamer sodium is an optimized aptamer based on SW1 aptamer (HY-160063) that specifically targets liver cancer SMMC-7721 cells (Kd: 133.73 nM). SW1-A aptamer maintains strong affinity to liver cancer tissues and cells .
  • HY-160052
    IL-6 aptamer sodium

    		Aptamers
    IL-6 aptamer sodium is a nucleic acid aptamer that specifically targets IL-6 and can be used for the specific detection of IL-6 .
  • HY-160049
    BC15 aptamer sodium

    		Aptamers
    BC15 aptamer sodium is an ssDNA aptamer targeting the intracellular protein hnRNP A1, which is highly expressed in cancerous liver tissue. BC15 aptamer sodium specifically recognizes breast cancer cells and can be used to detect cancer cells in other pathological types of breast cancer tissue .
  • HY-160068
    2-2(t) aptamer sodium

    		Aptamers
    2-2(t) aptamer sodium is a 42-nucleotide trimeric complex of aptamer (2-2) targeting ErbB-2. 2-2(t) aptamer sodium inhibits the growth of gastric cancer cells in vitro and in vivo .
  • HY-160063
    SW1 aptamer sodium

    		Aptamers
    SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis .
  • HY-160054
    GMT 3 aptamer sodium

    		Aptamers
    GMT 3 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity .
  • HY-160056
    GMT 5 aptamer sodium

    		Aptamers
    GMT 5 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity .
  • HY-160058
    GMT 9 aptamer sodium

    		Aptamers
    GMT 9 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity .
  • HY-160055
    GMT 4 aptamer sodium

    		Aptamers
    GMT 4 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .
  • HY-160057
    GMT 8 aptamer sodium

    		Aptamers
    GMT 8 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .
  • HY-160062
    S2.2 aptamer sodium

    		Aptamers
    S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM .
  • HY-153847
    RNA Aptamer Mango ΙΙ sodium

    		Aptamers
    RNA Aptamer Mango Ⅱ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅱ (sodium) has markedly improved fluorescent properties, binding affinities, and salt dependencies.
  • HY-153848
    RNA Aptamer Mango Ⅳ sodium

    		Aptamers
    RNA Aptamer Mango Ⅳ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅳ has markedly improved fluorescent properties, binding affinities, and salt dependencies.
  • HY-153849
    RNA Aptamer Mango Ⅲ sodium

    		Aptamers
    RNA Aptamer Mango Ⅲ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅲ has markedly improved fluorescent properties, binding affinities, and salt dependencies.
  • HY-160065
    sgc8c aptamer sodium

    		Aptamers
    sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. Binding of sgc8c aptamer sodium to PTK-7 induces the assembly of nanotags on the cell surface, resulting in strong fluorescence and SERS signals. Specific to cervical cancer cells .
  • HY-153843
    RNA Aptamer Corn sodium

    		Aptamers
    RNA Aptamer Corn (sodium) is a 28-nt-long aptamer that is substantially shorter than Spinach and Spinach2 and exhibits bright red fluorescence upon binding DFHO (a soluble analog of the intrinsic fluorophore of red fluorescent protein), RNA Aptamer Corn (sodium) can be used to visualize RNA expression or localization in live cells which have been soaked with chromophores. The Corn-DFHO does not become appreciably cytotoxic when illuminated. And most importantly, Corn-DFHO exhibits markedly increased photostability compared to other aptamer-chromophore complexes both in vitro and in vivo. (36 nt Corn construct: 5'-GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC-3'; A 36-nt RNA construct, comprised of the 28-nt minimal Corn sequence extended proximally with a 4 base-pair stem.)
  • HY-153846
    RNA Aptamer Mango I sodium

    		Aptamers
    RNA Aptamer Mango Ⅰ (sodium) consists of 39 nucleotides and has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore). RNA Aptamer Mango Ⅰ (sodium) can be used to visualize RNA expression or localization in live cells.
  • HY-160061
    P12FR2 aptamer sodium

    		Aptamers
    P12FR2 aptamer sodium is a 2'-fluoropyrimidine-modified RNA aptamer targeting human PAUF with an estimated apparent KD of 77 nM. P12FR2 aptamer sodium inhibits PAUF-induced migration of PANC-1 (human pancreatic cancer cells) in wound healing assays and suppresses tumor growth in a mouse CFPAC-1 pancreatic cancer model .
  • HY-153845
    RNA Aptamer Broccoli sodium

    		Aptamers
    RNA Aptamer Broccoli (sodium) is a 49-nt-long aptamer that is substantially shorter than Spinach and Spinach2 and exhibits bright green fluorescence upon binding DFHBI or DFHBI-1T (soluble analogs of the fluorophore of green fluorescent protein). RNA Aptamer Broccoli (sodium) can be used to visualize RNA expression or localization in live cells. In vitro Broccoli exhibits a similar high folding efficiency as Spinach2, but exhibits markedly lower dependence on magnesium for folding and increased thermostability. Additionally, unlike Spinach2, Broccoli does not require the use of a tRNA scaffold to promote its folding in vivo.
  • HY-153850
    RNA Aptamer Peach I sodium

    		Aptamers
    RNA Aptamer Peach Ⅰ (sodium) has an exceptionally high affinity to TO3-Biotin (TO3-B, red channel, ex: 637 nm, em: 658 nm), and can be used to visualize RNA expression or localization in live cells.
  • HY-153851
    RNA Aptamer Peach Ⅱ sodium

    		Aptamers
    RNA Aptamer Peach Ⅱ (sodium) has an exceptionally high affinity to TO3-Biotin (TO3-B, red channel, ex: 637 nm, em: 658 nm), and can be used to visualize RNA expression or localization in live cells.
  • HY-148100
    Emapticap pegol

    NOX-E36

    		 Aptamers
    Emapticap pegol is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .
  • HY-148100A
    Emapticap pegol sodium

    NOX-E36 sodium

    		 Aptamers
    Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .
  • HY-160041A
    Olaptesed pegol sodium

    		Antisense Oligonucleotides
    Olaptesed pegol sodium A pegylated-based L-oligoribonucleotide aptamer targeting CXCL12. Olaptesed pegol sodium neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment .
  • HY-160041
    Olaptesed pegol

    		Antisense Oligonucleotides
    Olaptesed pegol (NOX-A12) L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment .
  • HY-156501
    BT101 sodium

    		Aptamers
    BT101 (sodium), a complementary aptamer, has been developed to specifically inhibit BT100 function. BT100, a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .
  • HY-153836
    Anivamersen

    		Aptamers
    Anivamersen is an RNA aptamer to reverse the anticoagulant effect of the parenteral factor IXa inhibitor pegnivacogin. REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide.
  • HY-153836A
    Anivamersen sodium

    		Aptamers
    Anivamersen sodium is an RNA aptamer to reverse the anticoagulant effect of the parenteral factor IXa inhibitor pegnivacogin. REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide.
  • HY-153835
    Pegnivacogin

    		Aptamers
    Pegnivacogin is a novel RNA-aptamer based factor IXa inhibitor featuring a reversal agent, anivamersen.
  • HY-153835A
    Pegnivacogin sodium

    		Aptamers
    Pegnivacogin sodium is a novel RNA-aptamer based factor IXa inhibitor featuring a reversal agent, anivamersen.
  • HY-147081A
    AS 1411 sodium

    AGRO-100 sodium

    		 Aptamers
    AS1411 sodium is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. It has anti-tumor activity.
  • HY-153998
    BT100 sodium

    		Aptamers
    BT100 (sodium), a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .
  • HY-153480
    ARC19499

    BAX499

    		 Aptamers
    ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
  • HY-153480A
    ARC19499 sodium

    BAX499 sodium

    		 Aptamers
    ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
  • HY-147079A
    Egaptivon pegol sodium

    ARC 1779 sodium

    		 Aptamers
    Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.
  • HY-153999
    BT200

    		Aptamers
    BT200, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .
  • HY-153999A
    BT200 sodium

    		Aptamers
    BT200 sodium, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .
  • HY-147079
    Egaptivon pegol

    ARC 1779

    		 Aptamers
    Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.
  • HY-109561
    Pegaptanib sodium

    EYE001; NX1838

    		 Aptamers
    Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

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