Autophagy-related 4

By Targets:	Atg8/LC3 (1) Autophagy (1) Dopamine Transporter (1) ERK (1) Serotonin Transporter (1)
By Research Areas:	Cancer (2) Neurological Disease (1)

Targets Recommended: Autophagy Interleukin Related Atg4 Mas-related G-protein-coupled Receptor (MRGPR) Atg8/LC3 AUTOTACs AUTACs Mitophagy Trk Receptor ROR NEKs Kallikrein CGRP Receptor Arp2/3 Complex ATM/ATR sFRP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4180

Pennogenin 3-O-beta-chacotrioside	Atg8/LC3 Autophagy	Cancer
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates *autophagy* via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity .

HY-110019

Indatraline hydrochloride Lu 19-005	Serotonin Transporter Dopamine Transporter	Neurological Disease
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces *autophagy* while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis .

HY-162460

ERK1/2 inhibitor 10	ERK	Cancer
ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1 and ERK2 inhibitor (IC₅₀: 0.11 and 0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations .

Cat. No.	Product Name

HY-L029

Autophagy Compound Library	1,435 compounds
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 1,435 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Autophagy Compound Library

1,435 compounds

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

MCE provides a unique collection of 1,435 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4180

Pennogenin 3-O-beta-chacotrioside	Structural Classification Liliaceae Classification of Application Fields Source classification Paris polyphylla Smith Plants Disease Research Fields Steroids Cancer	Atg8/LC3 Autophagy
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates *autophagy* via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity .

Species:	Human (8)
Tag:	His (4) Tag Free (2) Myc (1) GST (1) MBP (1) Flag (2)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71576

	ATG14 Protein, Human (Myc, His) 4832427M01; ATG14; Atg14L; Autophagy-related protein 14-like protein; Barkor; Beclin 1-associated Autophagy-related key regulator; D14Ertd114e	Human	E. coli
	ATG14 is critical for basal and induced autophagy, determining PI3KC3-C1 localization, helping autophagosome formation and BECN1 translocation. It enhances PIK3C3 activity in a BECN1-dependent manner, which is essential for BECN1 phosphorylation. ATG14 Protein, Human (Myc, His) is the recombinant human-derived ATG14 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P7617

	ATG3 Protein, Human rHuATG3; Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3; APG3-like; ATG3; APG3; APG3L	Human	E. coli
	ATG3 Protein, Human is a recombinant human Ubiquitin-like-conjugating Enzyme ATG3 expressed in E. coli. ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy.

HY-P70909

	MAP1LC3B Protein, Human Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light cha	Human	E. coli
	MAP1LC3B is a key ubiquitin-like modifier essential for the formation of autophagosome vacuoles, which maintains cellular homeostasis. In mitophagy, it regulates mitochondrial number, suppresses reactive oxygen species and ensures energy efficiency. MAP1LC3B Protein, Human is the recombinant human-derived MAP1LC3B protein, expressed by E. coli , with tag free. The total length of MAP1LC3B Protein, Human is 125 a.a., with molecular weight of ~16.15 kDa.

HY-P701246

	ATG10 Protein, Human (GST) Ubiquitin-Like-Conjugating Enzyme ATG10; Autophagy-related Protein 10; APG10-Like; ATG10	Human	E. coli
	ATG10 Protein, Human (GST) is a recombinant human Autophagy Related 10 Homolog (ATG10) expressed in E. coli with a GST tag. ATG10 is an E2 ubiquitin-conjugating-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation.

HY-P702922

	ATG16L1 Protein, Human (P. pastoris, His) Autophagy-related protein 16-1; APG16-like 1; APG16L	Human	Sf9 insect cells
	ATG16L1 Protein, Human (P. pastoris, His) is the recombinant human-derived ATG16L1, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of ATG16L1 Protein, Human (P. pastoris, His) is 607 a.a.,

HY-P701358

	ATG9B Protein, Human (HEK293, FLAG) ATG9B; Autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE	Human	HEK293
	ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with C-Flag labeled tag. The total length of ATG9B Protein, Human (HEK293, FLAG) is 924 a.a., .

HY-P70916

	MAP1LC3A Protein, Human (His) Microtubule-Associated Proteins 1A/1B Light Chain 3A; Autophagy-related Protein LC3 A; Autophagy-related Ubiquitin-Like Modifier LC3 A; MAP1 Light Chain 3-Like Protein 1; MAP1A/MAP1B Light Chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-Associated Protein 1 Light Cha	Human	E. coli
	MAP1LC3A is a key ubiquitin-like modifier essential for autophagosome vacuole formation, ensuring cellular homeostasis. As part of the GABARAP/GATE-16 subfamily, it plays a crucial role in late autophagosome maturation. MAP1LC3A Protein, Human (His) is the recombinant human-derived MAP1LC3A protein, expressed by E. coli , with C-6*His labeled tag.

HY-P701359

	ATG9B Protein, Human (HEK293, His, MBP, FLAG) ATG9B; Autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE	Human	HEK293
	ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag. The total length of ATG9B Protein, Human (HEK293, His, MBP, FLAG) is 924 a.a., .

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81905

	ATG13 Antibody (YA1650) Autophagy-related protein 13	WB, IP	Human, Mouse, Rat
	ATG13 Antibody (YA1650) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1650), targeting ATG13, with a predicted molecular weight of 57 kDa (observed band size: 72 kDa). ATG13 Antibody (YA1650) can be used for WB, IP experiment in human, mouse, rat background.

HY-P80557

	ATG4A Antibody ATG4A; APG4A; AUTL2; Cysteine protease ATG4A; AUT-like 2 cysteine endopeptidase; Autophagin-2; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; hAPG4A	WB, IHC-P, IP	Human
	ATG4A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 45 kDa, targeting to ATG4A. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human .

HY-P80558

	ATG4C Antibody ATG4C; APG4C; AUTL1; AUTL3; Cysteine protease ATG4C; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C	WB, IHC-P	Human
	ATG4C Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to ATG4C. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81236

	ATG10 Antibody Autophagy related 10; APG10; APG10L; pp12616	WB, IHC-P	Human, Mouse
	ATG10 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 25 kDa, targeting to ATG10. It can be used for WB,IHC assays with tag free, in the background of Human and mouse.

HY-P80555

	ATG10 Antibody (YA603) Autophagy related 10; APG10; APG10L; pp12616	WB, IP	Human
	ATG10 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 25 kDa, targeting to ATG10. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80545

	APG5L Antibody APG 5L; APG5; APG5 Autophagy 5 like; APG5 like; APG5-like; Apoptosis specific protein; ASP; ATG 5; ATG5 Autophagy related 5 homolog; Autophagy protein 5; hAPG5	WB, ICC/IF, IP	Human, Mouse, Rat
	APG5L Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to APG5L. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82723

	ATG4B Antibody (YA2468) ATG4B; APG4B; AUTL1; KIAA0943; Cysteine protease ATG4B; AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B	WB, FC	Human, Mouse, Rat
	ATG4B Antibody (YA2468) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2468), targeting ATG4B, with a predicted molecular weight of 44 kDa (observed band size: 44 kDa). ATG4B Antibody (YA2468) can be used for WB, FC experiment in human, mouse, rat background.

HY-P82442

	ATG16L1 Antibody (YA2187) ATG16L1; APG16L; Autophagy-related protein 16-1; APG16-like 1	WB	Human, Mouse, Rat
	ATG16L1 Antibody (YA2187) is a biotin-conjugated non-conjugated IgG antibody, targeting ATG16L1, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). ATG16L1 Antibody (YA2187) can be used for WB experiment in human, mouse, rat background.

HY-P83336

	ATG9A Antibody (YA3081) ATG9A; APG9-like 1; Autophagy 9-like 1 protein; Autophagy-related protein 9A; MGD3208; MATG9; APG9 Autophagy 9-like 1; APG9L1; Autophagy related 9A	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	ATG9A Antibody (YA3081) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3081), targeting ATG9A, with a predicted molecular weight of 94 kDa. ATG9A Antibody (YA3081) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

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