BIG

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Biochemical Assay Reagents (2) Cholecystokinin Receptor (1) Endothelin Receptor (3) ERK (5) MMP (2) Potassium Channel (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (10) Infection (1) Inflammation/Immunology (1) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3733

Big Endothelin-1 (22-38), human	Endothelin Receptor	Cardiovascular Disease
Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38) .

HY-P3446A

Big Gastrin I (human) TFA	Cholecystokinin Receptor	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Big Gastrin I, human (TFA) is a gastrointestinal hormone consisting of 34 amino acids. Big Gastrin I, human (TFA) can be used as a potential substance for the study of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological diseases or cardiovascular diseases .

HY-P5130

Big endothelin-1 (rat 1-39)	Endothelin Receptor	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

HY-P2539

Big Endothelin-1 (1-39), porcine	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo .

HY-W155121

Big CHAP N,N-Bis(3-D-gluconamidopropyl)cholamide	Biochemical Assay Reagents	Others
Big CHAP are aqueous micelles of anionic cholate analogues .

HY-P2538

Big Endothelin-1 (1-38), human	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-38), human is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide .

HY-164652

m-BBIG dihydrochloride	Biochemical Assay Reagents	Others
m-BBIG dihydrochloride is a member of Bis-iminoguanidine (BIG) family and can be utilized in synthetic chemistry .

HY-18211

CGS 35601	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC₅₀s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats .

HY-P4159

Endothelin-1 (1-31) (Human)	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159B

Endothelin-1 (1-31) (Human) acetate	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159A

Endothelin-1 (1-31) (Human) TFA 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase .

HY-15402

Edonentan BMS 207940	Endothelin Receptor	Cardiovascular Disease
Edonentan (BMS 207940) is an antagonist for endothelin receptor (ET_A receptor), with a K_i of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P3513A

β-Neo-Endorphin acetate	ERK MMP	Neurological Disease
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-13103

NS 11021 2 Publications Verification	Potassium Channel	Others
NS 11021 is a potent and specific *Ca ²⁺-activated big-conductance K ⁺ Channels (KCa1.1 channels)* activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials .

Cat. No.	Product Name	Type

HY-W155121

Big CHAP N,N-Bis(3-D-gluconamidopropyl)cholamide	Surfactants
Big CHAP are aqueous micelles of anionic cholate analogues .

Cat. No.	Product Name	Target	Research Area

HY-P3733

Big Endothelin-1 (22-38), human	Endothelin Receptor	Cardiovascular Disease
Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38) .

HY-P3446A

Big Gastrin I (human) TFA	Cholecystokinin Receptor	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Big Gastrin I, human (TFA) is a gastrointestinal hormone consisting of 34 amino acids. Big Gastrin I, human (TFA) can be used as a potential substance for the study of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological diseases or cardiovascular diseases .

HY-P5130

Big endothelin-1 (rat 1-39)	Endothelin Receptor	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

HY-P3734

Big Endothelin-2 (1-38), human	Peptides	Others
Big Endothelin-2 (1-38), human is a polypeptide.

HY-P2539

Big Endothelin-1 (1-39), porcine	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo .

HY-P2538

Big Endothelin-1 (1-38), human	Vasopressin Receptor	Cardiovascular Disease
Big Endothelin-1 (1-38), human is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide .

HY-P4912

Big Endothelin-1 (rat)	Peptides	Others
Big Endothelin-1 (rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5080

Big Endothelin-2 (human)	Peptides	Others
Big Endothelin-2 (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4915

Big Endothelin-3 (22-41) amide (human)	Peptides	Others
Big Endothelin-3 (22-41) amide (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3569

*[D-Val22, Phe33] Big* Endothelin-1 (16-38), human**	Peptides	Others
[D-Val22, Phe33] Big Endothelin-1 (16-38), human is a polypeptide.

HY-P4159

Endothelin-1 (1-31) (Human)	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159B

Endothelin-1 (1-31) (Human) acetate	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159A

Endothelin-1 (1-31) (Human) TFA 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .

Species:	Human (7) Rat (2) Mouse (2)
Tag:	His (8) Tag Free (1) Avi (1) Fc (2)
Source:	HEK293 (6) Sf9 insect cells (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P703615

	WDR5 Protein, Human BIG3	Human	E. coli
	WDR5 Protein, Human is the recombinant human-derived WDR5, expressed by E. coli , with tag Free labeled tag. ,

HY-P71058

	PDYN Protein, Human (HEK293, His) ADCA; PENKB; SCA23; PDYN; Dynorphin B; BIG Dyn	Human	HEK293
	The PDYN protein, or prodynorphin, regulates Leu-enkephalins, mimicking opiate drug effects and impacting pain perception and stress responses. Dynorphin peptides, like Dynorphin A(1-13), uniquely regulate the kappa opioid receptor, with A(1-13) being exceptionally potent—700 times stronger than Leu-enkephalin—displaying typical opioid activity. PDYN Protein, Human (HEK293, His) is the recombinant human-derived PDYN protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74226

	Contactin-3/CNTN3 Protein, Rat (HEK293, His) Contactin-3; BIG-1; CNTN3; KIAA1496; PANG	Rat	HEK293
	Contactin-3/CNTN3 protein mediates crucial cell surface interactions in nervous system development and promotes neurite outgrowth. It interacts with PTPRG, indicating its involvement in signaling mechanisms that regulate neuronal growth and connectivity. Contactin-3/CNTN3 Protein, Rat (HEK293, His) is the recombinant rat-derived Contactin-3/CNTN3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74228

	Contactin-3/CNTN3 Protein, Mouse (HEK293, His) Contactin-3; BIG-1; CNTN3; KIAA1496; PANG	Mouse	HEK293
	Contactin-3/CNTN3 protein facilitates cell surface interactions in nervous system development, promoting neurite outgrowth and interacting with PTPRG to regulate neuronal growth and connectivity.Contactin-3/CNTN3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Contactin-3/CNTN3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72947

	Contactin-3/CNTN3 Protein, Human (N708D, HEK293, Fc) Contactin-3; BIG-1; CNTN3; KIAA1496; PANG	Human	HEK293
	Contactin-3/CNTN3 protein, a member of the contactin family, facilitates cell surface interactions crucial for nervous system development. It exhibits neurite outgrowth-promoting activity, contributing to the intricate processes involved in the formation and maturation of neural circuits. Additionally, Contactin-3/CNTN3 interacts with PTPRG, indicating its involvement in signaling pathways that govern neural cell communication and connectivity. Contactin-3/CNTN3 Protein, Human (N708D, HEK293, Fc) is the recombinant human-derived Contactin-3/CNTN3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74229

	Contactin-3/CNTN3 Protein, Human (N708D, HEK293, His) Contactin-3; BIG-1; CNTN3; KIAA1496; PANG	Human	HEK293
	Contactin-3/CNTN3 protein, a member of the contactin family, facilitates cell surface interactions crucial for nervous system development. It exhibits neurite outgrowth-promoting activity, contributing to the intricate processes involved in the formation and maturation of neural circuits. Additionally, Contactin-3/CNTN3 interacts with PTPRG, indicating its involvement in signaling pathways that govern neural cell communication and connectivity. Contactin-3/CNTN3 Protein, Human (N708D, HEK293, His) is the recombinant human-derived Contactin-3/CNTN3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702880

	WDR5 Protein, Human (sf9, His) BIG3	Human	Sf9 insect cells
	WDR5 Protein, Human (sf9, His) is the recombinant human-derived WDR5, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

HY-P702881

	WDR5 Protein, Human (Biotinylated, sf9, Avi, His) BIG3	Human	Sf9 insect cells
	WDR5 Protein, Human (Biotinylated, sf9, Avi, His) is the recombinant human-derived WDR5, expressed by Sf9 insect cells , with Avi, His labeled tag. ,

HY-P74227

	Contactin-3/CNTN3 Protein, Rat (HEK293, Fc) Contactin-3; BIG-1; CNTN3; KIAA1496; PANG	Rat	HEK293
	Contactin-3/CNTN3 protein mediates crucial cell surface interactions in nervous system development and promotes neurite outgrowth. It interacts with PTPRG, indicating its involvement in signaling mechanisms that regulate neuronal growth and connectivity. Contactin-3/CNTN3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Contactin-3/CNTN3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75681

	CNTN4/Contactin-4 Protein, Mouse (sf9, His) Contactin-4; Brain-derived immunoglobulin superfamily protein 2; BIG-2	Mouse	Sf9 insect cells
	CNTN4/Contactin-4 protein mediates cell surface interactions in nervous system development and promotes neurite outgrowth. Its involvement in synaptogenesis highlights its significance in shaping neural connectivity. CNTN4 also interacts with PTPRG, potentially regulating neuronal functions and synaptic development. CNTN4/Contactin-4 Protein, Mouse (sf9, His) is the recombinant mouse-derived CNTN4/Contactin-4 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P76277

	CNTN4/Contactin-4 Protein, Human (sf9, His) Contactin-4; Brain-derived immunoglobulin superfamily protein 2; BIG-2	Human	Sf9 insect cells
	The CNTN4/Contactin-4 protein is a member of the contactin family and plays a key role in promoting cell surface interactions critical for nervous system development. It has proven neurite growth-promoting activity, assisting in the complex processes involved in neuronal growth. CNTN4/Contactin-4 Protein, Human (sf9, His) is the recombinant human-derived CNTN4/Contactin-4 protein, expressed by Sf9 insect cells , with C-His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82401

	ARFGEF2 Antibody (YA2146) BIG2; PVNH2; dJ1164I10.1	WB	Human, Mouse, Rat
	ARFGEF2 Antibody (YA2146) is a non-conjugated IgG antibody, targeting ARFGEF2, with a predicted molecular weight of 202 kDa (observed band size: 202 kDa). ARFGEF2 Antibody (YA2146) can be used for WB experiment in human, mouse, rat background.

HY-P82523

	TGFBI Antibody (YA2268) Beta ig; Beta ig h3; Beta ig-h3; BGH3_HUMAN; BIG h3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato epithelin; Kerato-epithelin; LCD1	WB, IHC-P	Human, Mouse, Rat
	TGFBI Antibody (YA2268) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2268), targeting TGFBI, with a predicted molecular weight of 75 kDa (observed band size: 68 kDa). TGFBI Antibody (YA2268) can be used for WB, IHC-P experiment in human, mouse, rat background.

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