Search Result

Results for "

Bone metabolism

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (4) Autophagy (3) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (1) Caspase (1) Endogenous Metabolite (7) ERK (2) Estrogen Receptor/ERR (3) Fluorescent Dye (2) GLUT (1) Glutathione Peroxidase (1) HIV (1) Influenza Virus (1) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (3) MMP (1) Parasite (4) Phosphatase (2) Proton Pump (1) Reactive Oxygen Species (3) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (2) VD/VDR (1) Virus Protease (1) VSV (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (5) Endocrinology (2) Infection (6) Inflammation/Immunology (6) Metabolic Disease (17) Neurological Disease (3)

By Targets:

Androgen Receptor (1)

Apoptosis (4)

Autophagy (3)

Bacterial (1)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Caspase (1)

Endogenous Metabolite (7)

ERK (2)

Estrogen Receptor/ERR (3)

Fluorescent Dye (2)

GLUT (1)

Glutathione Peroxidase (1)

HIV (1)

Influenza Virus (1)

Integrin (1)

Interleukin Related (2)

Isotope-Labeled Compounds (3)

MMP (1)

Parasite (4)

Phosphatase (2)

Proton Pump (1)

Reactive Oxygen Species (3)

TGF-beta/Smad (1)

TGF-β Receptor (1)

TNF Receptor (2)

VD/VDR (1)

Virus Protease (1)

VSV (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (5)

Endocrinology (2)

Infection (6)

Inflammation/Immunology (6)

Metabolic Disease (17)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Mitochondrial Metabolism

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1249

Calcein (mixture of isomers)	Fluorescent Dye	Others
Calcein mixture of isomers is a calcium-dependent fluorescent molecule. Calcein mixture of isomers can be used to study bone metabolism (in vivo) and to stain depressed areas (in vitro). Calcein mixture of isomers can also be used for fluorometry and EDTA titration of calcium ion.

HY-12398A

TEI-9648 1 Publications Verification	VD/VDR	Metabolic Disease Inflammation/Immunology
TEI-9648, a Vitamin D₃ Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9648 has the potential for bone metabolism research .

HY-N0684

Vitamin K1 4 Publications Verification Phylloquinone; Phytomenadione	Endogenous Metabolite	Cardiovascular Disease Cancer
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-N0684S

Vitamin K1-d7	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1-d₇ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].

HY-N2532

Diphyllin	VSV HIV Proton Pump Influenza Virus	Infection Inflammation/Immunology Cancer
Diphyllin is an orally active V-ATPase inhibitor (IC₅₀=17 nM) and HIV-1 inhibitor (IC₅₀=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC₅₀=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .

HY-13273

Ostarine 2 Publications Verification MK-2866; GTX-024; Enobosarm	Androgen Receptor	Others Cancer
Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism .

HY-P4588

(Glu17,21,24)-Osteocalcin (1-49) (human)	GLUT	Metabolic Disease
(Glu17,21,24)-Osteocalcin (1-49) (human) is a bone-specific protein involved in bone formation and glucose metabolism .

HY-N0684S1

Vitamin K1-d4 Phylloquinone-d₄; Phytomenadione-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

HY-P10237

Calcitonin (chicken)	Calcium Channel	Others
Calcitonin chicken is a hormone, that regulates calcium metabolism. Calcitonin chicken suppresses the cell motility and bone resorption in neonatal rat osteoclasts .

HY-N0684S3

Vitamin K1-13C6 Phylloquinone-¹³C₆; Phytomenadione-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-162866

CXM102	Autophagy	Metabolic Disease
CXM102 is an autophagy activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice .

HY-N0684R

Vitamin K1 (Standard)	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1 (Standard) is the analytical standard of Vitamin K1. This product is intended for research and analytical applications. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-13738A

Raloxifene hydrochloride Maximum Cited Publications 13 Publications Verification Keoxifene hydrochloride; LY156758; LY139481 hydrochloride	Estrogen Receptor/ERR Autophagy	Endocrinology Cancer
Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

HY-B0119

Risedronic acid sodium 1 Publications Verification Risedronate sodium	Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

HY-B0148

Risedronic acid 1 Publications Verification Risedronate	Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Risedronate), a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

HY-N1499

Nystose	Wnt β-catenin TGF-beta/Smad Bacterial	Infection Metabolic Disease Inflammation/Immunology
Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the Wnt/β-catenin signaling pathway .

HY-B0148R

Risedronic acid (Standard) Risedronate (Standard)	Parasite	Infection Metabolic Disease Cancer
Risedronic acid (Standard) (Risedronate (Standard)) is the analytical standard of Risedronic acid (HY-B0148). This product is intended for research and analytical applications.Risedronic acid (Risedronate), a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins.

HY-13738AR

Raloxifene (hydrochloride) (Standard) Maximum Cited Publications 13 Publications Verification Keoxifene (hydrochloride)(Standard); LY156758(Standard); LY139481 (hydrochloride) (Standard)	Estrogen Receptor/ERR Autophagy	Endocrinology Cancer
Raloxifene (hydrochloride) (Standard) is the analytical standard of Raloxifene (hydrochloride). This product is intended for research and analytical applications. Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

HY-P990022

Prafnosbart DS-6016A	TGF-β Receptor	Metabolic Disease
Prafnosbart (DS-6016A) is an IgG1-kappa, anti-ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1) humanized monoclonal antibody. Prafnosbart can be used for bone metabolism disorders research .

HY-P2633A

Dentonin TFA AC-100 TFA	Integrin	Metabolic Disease
Dentonin TFA (AC-100 TFA) is a synthetic fragment derived from MEPE. Dentonin TFA enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin TFA has no significant effect to mature osteoblasts. Dentonin TFA can be used for the research of phosphate homeostasis and bone metabolism .

HY-B0148S

Risedronic acid-d4 Risedronate-d₄	Isotope-Labeled Compounds Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148).Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

HY-114631

EM-800	Estrogen Receptor/ERR	Cancer
EM-800, an orally active anti-estrogen, serves as an antagonist to the transcriptional functions of estrogen receptors α (ERα) and β (ERβ). EM-800 possesses anticancer activity, capable of inhibiting the growth of breast cancer induced by 7,12-Dimethylbenz[a]anthracene (DMBA) (HY-W011845). Furthermore, in ovariectomized animals, EM-800 effectively slows down bone loss. Additionally, EM-800 shows potential in the research of breast and endometrial cancers, while exerting beneficial effects on bone and lipid metabolism .

HY-W110927

Alizarin Red S Indicator (4.3-6.3), IND 5+ Cited Publications	Biochemical Assay Reagents Fluorescent Dye	Others
Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research .

HY-D0886

β-Glycerophosphate disodium salt pentahydrate Maximum Cited Publications 13 Publications Verification	Phosphatase Endogenous Metabolite ERK	Metabolic Disease Cancer
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

HY-126304

β-Glycerophosphate disodium salt hydrate Maximum Cited Publications 13 Publications Verification	Phosphatase Endogenous Metabolite ERK	Metabolic Disease
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

HY-N8837

Trifloroside	MMP	Metabolic Disease
Trifloroside is a secoiridoid glycoside with antioxidant effects. Trifloroside induces osteogenic effects through osteoblast differentiation, adhesion, migration, and mineral apposition. Trifloroside has the potential for osteoblast-mediated bone diseases research .

HY-B0388

Probucol 1 Publications Verification DH-581	Virus Protease Apoptosis Reactive Oxygen Species Glutathione Peroxidase Caspase	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Probucol (DH-581) is an anti-hyperlipidemic agent. Probucol activates glutathione peroxidase. Probucol promotes low density lipoprotein (LDL) catabolism, inhibits ABCA1-dependent cholesterol efflux, and decreases HDL-C levels. Probucol also has anti-inflammatory, antioxidant and neuroprotective properties. Probucol can be used for researches on bone, cardiovascular, cancer, neurological, and metabolism-related diseases .

HY-130237

Cinnamtannin B-1	Reactive Oxygen Species	Metabolic Disease Cancer
Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers .

HY-130237R

Cinnamtannin B-1 (Standard)	Reactive Oxygen Species	Metabolic Disease Cancer
Cinnamtannin B-1 (Standard) is the analytical standard of Cinnamtannin B-1. This product is intended for research and analytical applications. Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers .

HY-N0507

Rosavin	TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

HY-N0507R

Rosavin (Standard)	TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Rosavin (Standard) is the analytical standard of Rosavin. This product is intended for research and analytical applications. Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

Cat. No.	Product Name

HY-L197

Vitamin Compound Library	142 compounds
Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases. MCE included 142 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.

Vitamin Compound Library

142 compounds

Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases.

MCE included 142 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.

Cat. No.	Product Name	Type

HY-D1249

Calcein (mixture of isomers)	Fluorescent Dyes/Probes
Calcein mixture of isomers is a calcium-dependent fluorescent molecule. Calcein mixture of isomers can be used to study bone metabolism (in vivo) and to stain depressed areas (in vitro). Calcein mixture of isomers can also be used for fluorometry and EDTA titration of calcium ion.

Cat. No.	Product Name	Type

HY-W110927

Alizarin Red S Indicator (4.3-6.3), IND 5+ Cited Publications	Indicators
Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research .

Alizarin Red S Indicator (4.3-6.3), IND

5+ Cited Publications

Indicators

Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research .

Cat. No.	Product Name	Target	Research Area

HY-P2633

Dentonin AC-100	Peptides	Metabolic Disease
Dentonin (AC-100) is a synthetic fragment derived from MEPE. Dentonin enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin has no significant effect to mature osteoblasts. Dentonin can be used for the research of phosphate homeostasis and bone metabolism .

HY-P4588

(Glu17,21,24)-Osteocalcin (1-49) (human)	GLUT	Metabolic Disease
(Glu17,21,24)-Osteocalcin (1-49) (human) is a bone-specific protein involved in bone formation and glucose metabolism .

HY-P10237

Calcitonin (chicken)	Calcium Channel	Others
Calcitonin chicken is a hormone, that regulates calcium metabolism. Calcitonin chicken suppresses the cell motility and bone resorption in neonatal rat osteoclasts .

HY-P2633A

Dentonin TFA AC-100 TFA	Integrin	Metabolic Disease
Dentonin TFA (AC-100 TFA) is a synthetic fragment derived from MEPE. Dentonin TFA enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin TFA has no significant effect to mature osteoblasts. Dentonin TFA can be used for the research of phosphate homeostasis and bone metabolism .

Cat. No.	Product Name	Target	Research Area

HY-P990022

Prafnosbart DS-6016A	TGF-β Receptor	Metabolic Disease
Prafnosbart (DS-6016A) is an IgG1-kappa, anti-ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1) humanized monoclonal antibody. Prafnosbart can be used for bone metabolism disorders research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0684

Vitamin K1 4 Publications Verification Phylloquinone; Phytomenadione	Cardiovascular Disease Quinones Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Classification of Application Fields Source classification Plants Endogenous metabolite Naphthalene Quinones Disease Research Fields	Endogenous Metabolite
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-N2532

Diphyllin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Plants Infection Monophenols Phenols Phenylpropanoids Berberidaceae Inflammation/Immunology Disease Research Fields	VSV HIV Proton Pump Influenza Virus
Diphyllin is an orally active V-ATPase inhibitor (IC₅₀=17 nM) and HIV-1 inhibitor (IC₅₀=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC₅₀=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .

HY-13738A

Raloxifene hydrochloride Maximum Cited Publications 13 Publications Verification Keoxifene hydrochloride; LY156758; LY139481 hydrochloride	Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Plants Disease Research Fields Tetradium ruticarpum (A. Jussieu) T. G. Hartley Endocrinology Cancer	Estrogen Receptor/ERR Autophagy
Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

HY-N1499

Nystose	Structural Classification Polysaccharides Classification of Application Fields Source classification Rubiaceae Metabolic Disease Plants Morinda officinalis How Disease Research Fields Saccharides	Wnt β-catenin TGF-beta/Smad Bacterial
Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the Wnt/β-catenin signaling pathway .

HY-13738AR

Raloxifene (hydrochloride) (Standard) Maximum Cited Publications 13 Publications Verification Keoxifene (hydrochloride)(Standard); LY156758(Standard); LY139481 (hydrochloride) (Standard)	Structural Classification Alkaloids Classification of Application Fields Source classification Rutaceae Phenols Plants Disease Research Fields Tetradium ruticarpum (A. Jussieu) T. G. Hartley Endocrinology Cancer	Estrogen Receptor/ERR Autophagy
Raloxifene (hydrochloride) (Standard) is the analytical standard of Raloxifene (hydrochloride). This product is intended for research and analytical applications. Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .

HY-D0886

β-Glycerophosphate disodium salt pentahydrate Maximum Cited Publications 13 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Phosphatase Endogenous Metabolite ERK
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

HY-126304

β-Glycerophosphate disodium salt hydrate Maximum Cited Publications 13 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Endogenous Metabolite ERK
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

HY-130237

Cinnamtannin B-1	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Reactive Oxygen Species
Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers .

HY-N0684R

Vitamin K1 (Standard)	Quinones Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Source classification Plants Endogenous metabolite Naphthalene Quinones	Endogenous Metabolite
Vitamin K1 (Standard) is the analytical standard of Vitamin K1. This product is intended for research and analytical applications. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-N8837

Trifloroside	Structural Classification Gentiana scabra Bunge Polysaccharides Source classification Gentianaceae Plants Saccharides	MMP
Trifloroside is a secoiridoid glycoside with antioxidant effects. Trifloroside induces osteogenic effects through osteoblast differentiation, adhesion, migration, and mineral apposition. Trifloroside has the potential for osteoblast-mediated bone diseases research .

HY-130237R

Cinnamtannin B-1 (Standard)	Structural Classification Anthocyans Flavonoids other families Source classification Phenols Polyphenols Plants	Reactive Oxygen Species
Cinnamtannin B-1 (Standard) is the analytical standard of Cinnamtannin B-1. This product is intended for research and analytical applications. Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers .

HY-N0507

Rosavin	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	TNF Receptor Interleukin Related
Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

HY-N0507R

Rosavin (Standard)	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	TNF Receptor Interleukin Related
Rosavin (Standard) is the analytical standard of Rosavin. This product is intended for research and analytical applications. Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

Cat. No.	Product Name	Chemical Structure

HY-N0684S

Vitamin K1-d7
Vitamin K1-d₇ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].

HY-N0684S1

Vitamin K1-d4
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

HY-N0684S3

Vitamin K1-13C6
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-B0148S

Risedronic acid-d4

Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148).Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

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Bone metabolism

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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