2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Cinnamtannin B-1

Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers.

For research use only. We do not sell to patients.

Cinnamtannin B-1 Chemical Structure

Cinnamtannin B-1 Chemical Structure

CAS No. : 88082-60-4

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1 mg USD 120 In-stock
5 mg USD 260 In-stock
10 mg USD 435 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers[1][2].

IC50 & Target

Reactive oxygen species[1]
Molecular Weight

864.76

Formula

C45H36O18
CAS No.
Appearance

Solid

Color

White to pink

SMILES

O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C4C(O[C@]5(C6=CC=C(O)C(O)=C6)OC7=CC(O)=CC(O)=C7[C@@]4([H])[C@H]5O)=CC(O)=C3[C@@H]1C8=C9C(C[C@@H](O)[C@@H](C%10=CC=C(O)C(O)=C%10)O9)=C(O)C=C8O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (115.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1564 mL 5.7820 mL 11.5639 mL
5 mM 0.2313 mL 1.1564 mL 2.3128 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.25%

COA (265 KB) HNMR (145 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1564 mL 5.7820 mL 11.5639 mL 28.9098 mL
5 mM 0.2313 mL 1.1564 mL 2.3128 mL 5.7820 mL
10 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8910 mL
15 mM 0.0771 mL 0.3855 mL 0.7709 mL 1.9273 mL
20 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
25 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1564 mL
30 mM 0.0385 mL 0.1927 mL 0.3855 mL 0.9637 mL
40 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7227 mL
50 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.5782 mL
60 mM 0.0193 mL 0.0964 mL 0.1927 mL 0.4818 mL
80 mM 0.0145 mL 0.0723 mL 0.1445 mL 0.3614 mL
100 mM 0.0116 mL 0.0578 mL 0.1156 mL 0.2891 mL
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Cinnamtannin B-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinnamtannin B-188082-60-4Cinnamtannin B1Cinnamtannin B 1Reactive Oxygen SpeciesOsteoclast formationOsteoporosisOPBone metabolismsteoporosiscolon cancerproanthocyanidinInhibitorinhibitorinhibit

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