2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related
  4. Rosavin

Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis.

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Rosavin Chemical Structure

Rosavin Chemical Structure

CAS No. : 84954-92-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
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10 mM * 1 mL in DMSO USD 55 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Rosavin:

Rosavin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis[1][2][3][4].
In Vitro

Rosavin (0-100 μM, 72 h) shows more protective effect on the cell viability at a low concentration in the irradiated intestinal epithelioid cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rosavin Related Antibodies

Cell Viability Assay[1]

Cell Line: Intestinal Epithelioid Cell lines
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Exhibited cytotoxic impacts on IEC cells and inhibited the strongest effect at a low concentration of 12.5 μM in IEC cells.
In Vivo

Rosavin (2 ml, 200 mg/kg, i.g., 7 days) significantly increases survival rate in irradiated rats and improves the intestinal structure and function on radiation-induced intestinal injury[1].
Rosavin (2 ml, 200 mg/kg, i.g., assay at day 1, 3, 5, and 7 day after radiation) significantly reduces the level of TNF-α, IL-1β, neutrophil infiltration and increases the level of IL-10 in irradiated rats, thereby attenuates inflammatory damage caused by radiation. Additionally, Rosavin exerts anti-oxidation property in irradiated rats[1][2].
Rosavin (2.5, 5, 10 mg/kg, infusion, daily for 3 days) protects against Ischemia–reperfusion (I/R)-induced cerebral injury in vivo and attenuates I/R-induced inflammation both in mice and HBMVECs. Additionally, Rosavin exhibits I/R-induced apoptosis in mouse brain tissues and significantly suppresses the activation of the phosphorylation of ERK1/2, p38 and JNK1/2 both in vivo and in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Irradiated rats
Dosage: 200 mg/kg
Administration: i.g., assay at day 1, 3, 5, and 7 day after radiation
Result: Significantly increased survival rate in irradiated rats (P< 0.01) and effectively elevated the activities of anti-oxidant enzymes (SOD, CAT and GPx) in irradiated rats[1]
Molecular Weight

428.43

Formula

C20H28O10
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O[C@@H]([C@H](O)[C@H]1O)[C@H](O[C@H]1OC/C=C/C2=CC=CC=C2)CO[C@H](OC[C@H](O)[C@@H]3O)[C@@H]3O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (233.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (116.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3341 mL 11.6705 mL 23.3410 mL
5 mM 0.4668 mL 2.3341 mL 4.6682 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 20 mg/mL (46.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.99%

COA (256 KB) HNMR (291 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.3341 mL 11.6705 mL 23.3410 mL 58.3526 mL
5 mM 0.4668 mL 2.3341 mL 4.6682 mL 11.6705 mL
10 mM 0.2334 mL 1.1671 mL 2.3341 mL 5.8353 mL
15 mM 0.1556 mL 0.7780 mL 1.5561 mL 3.8902 mL
20 mM 0.1167 mL 0.5835 mL 1.1671 mL 2.9176 mL
25 mM 0.0934 mL 0.4668 mL 0.9336 mL 2.3341 mL
30 mM 0.0778 mL 0.3890 mL 0.7780 mL 1.9451 mL
40 mM 0.0584 mL 0.2918 mL 0.5835 mL 1.4588 mL
50 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1671 mL
60 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9725 mL
80 mM 0.0292 mL 0.1459 mL 0.2918 mL 0.7294 mL
100 mM 0.0233 mL 0.1167 mL 0.2334 mL 0.5835 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Rosavin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosavin84954-92-7TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILRadiation-induced intestinal injuryRRLAnti-inflammationAnti-oxidant reactionIEC cell lineAntidepressionBone tissue metabolismOsteoporosisInhibitorinhibitorinhibit

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