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Bradykinin Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bradykinin Receptor (38) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Bombesin Receptor (1) ERK (1) Isotope-Labeled Compounds (1) mAChR (1) Opioid Receptor (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (9) Endocrinology (14) Inflammation/Immunology (20) Metabolic Disease (7) Neurological Disease (11)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Bradykinin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103290

R715	Bradykinin Receptor	Others
R715 is a selective bradykinin B1 receptor antagonist. R715 significantly attenuates the hyperalgesic effect developed in Streptozotocin(HY-13753)-diabetic mice .

HY-121156A

Anatibant hydrochloride LF 16-0687 hydrochloride; XY-2405 hydrochloride	Bradykinin Receptor	Neurological Disease
Anatibant (LF 16-0687; XY-2405) hydrochloride is a selective non-peptide **bradykinin B2 receptor** antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with K_i values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases .

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts .

HY-P0298A

[Des-Arg9]-Bradykinin acetate 1 Publications Verification	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin acetate is a **Bradykinin B₁ receptor** agonist that displays selectivity for B₁ over B₂ receptors.

HY-158262

Bradykinin B1 receptor antagonist 1	Bradykinin Receptor	Neurological Disease
Bradykinin B1 receptor antagonist 1 (compound 6B) is a potent and cross the blood-brain barrier bradykinin B1 antagonist. Bradykinin B1 receptor antagonist 1 has the potential for the research of pain .

HY-P3209

Des-Arg9-[Leu8]-Bradykinin acetate	Bradykinin Receptor	Inflammation/Immunology
Des-Arg9-[Leu8]-Bradykinin acetate is potent bradykinin receptor 1 (B1R) antagonist. Des-Arg9-[Leu8]-Bradykinin acetate can be used for renal fibrosis research .

HY-123376

FR-190997	Bradykinin Receptor	Neurological Disease
FR-190997 is a non-peptide **Bradykinin B2 receptor selective agonist, K_i** value is 9.8 nM. FR-190997 is also an effective antihypertensive agent .

HY-14886

Fasitibant chloride MEN16132 free base	Bradykinin Receptor	Cardiovascular Disease Neurological Disease
Fasitibant chloride (MEN16132 free base) is a potent and selective nonpeptide bradykinin B2 receptor (B2R) antagonist. Fasitibant chloride reduces joint pain and diminishes joint oedema in Carrageenan-induced arthritis rat model .

HY-121156

Anatibant LF 16-0687; XY-2405	Bradykinin Receptor	Neurological Disease
Anatibant (LF 16-0687; XY-2405) is a selective non-peptide **bradykinin B2 receptor** antagonist. Anatibant binds to the human, rat and guinea-pig recombinant B2 receptor with K_i values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant crosses the blood-brain barrier (BBB). Anatibant can be used in research on brain damage diseases .

HY-P0298

[Des-Arg9]-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin is a *Bradykinin* (B₁) receptor agonist that displays selectivity for B₁ over B₂ receptors.

HY-103295

Lys-[Des-Arg9]Bradykinin	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective **bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse** and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors .

HY-103295A

Lys-[Des-Arg9]Bradykinin TFA	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective **bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse** and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors .

HY-P4676

Lys-(Des-Arg9,Leu8)-Bradykinin	Bradykinin Receptor	Endocrinology
Lys-(Des-Arg9,Leu8)-Bradykinin is a bradykinin B1 receptor antagonist .

HY-103292

[Phe8Ψ(CH-NH)Arg9]-Bradykinin	Bradykinin Receptor	Cardiovascular Disease
[Phe8Ψ(CH-NH)Arg9]-Bradykinin is a selective Bradykinin receptor B₂ agonist (not cleaved by protein kinase I/II). [Phe8Ψ(CH-NH)Arg9]-Bradykinin has potential for the research of hypertension .

HY-P3751

[Tyr8] Bradykinin	Bradykinin Receptor ERK	Cardiovascular Disease Endocrinology
[Tyr8] Bradykinin is a B₂ kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard .

HY-147273

Fulimetibant	Bradykinin Receptor	Others
Fulimetibant is a **bradykinin receptor** antagonist .

HY-103293A

Lys-Bradykinin TFA Kallidin (380-389) (human, porcine, bovine) TFA	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin (HY-103293). Lys-Bradykinin TFA is a ligand for kallidin and **bradykinin receptor*, which can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin* TFA serves as a vasodilator, which widens blood vessels and increases blood flow. Lys-Bradykinin TFA stimulates net Na+ influx, and contributes to DNA synthesis. Lys-Bradykinin TFA involves in vascular regulation, inflammation and pain sensation .

HY-103293

Lys-Bradykinin Kallidin (380-389) (human, porcine, bovine)	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin, a kind of kallidin and **bradykinin receptor** ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation .

HY-101368A

WIN 64338 hydrochloride	Bradykinin Receptor mAChR	Neurological Disease
WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of **bradykinin B2 receptor*. WIN 64338 hydrochloride inhibits [ ³H]-Bradykinin* binding to the bradykinin B2 receptor on human IMR-90 cells with a K_i of 64 nM. WIN 64338 hydrochloride also can inhibits [ ³H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (K_i=350 nM) .

HY-103293B

Lys-Bradykinin tetraacetate Kallidin (380-389) (human, porcine, bovine) tetraacetate	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and **bradykinin receptor** ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation .

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

HY-15043

ELN-441958	Bradykinin Receptor	Inflammation/Immunology Endocrinology
ELN-441958 is a potent, neutral, competitive and selective **bradykinin B₁ receptor antagonist with a K_i** of 0.26 nM against native human bradykinin B₁ receptor. ELN-441958 has high oral bioavailability, and has low CNS exposure in the mouse .

HY-105155

Lobradimil RMP 7	Bradykinin Receptor	Cancer
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective **bradykinin B2 receptor agonist (K_i**: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors .

HY-103296

Bombinakinin M	Bradykinin Receptor	Endocrinology
Bombinakinin M is a **bradykinin receptor** agonist with contractile activity in the guinea pig ileum .

HY-P3232

B 9430	Bradykinin Receptor	Inflammation/Immunology Endocrinology
B 9430 is a potent **bradykinin B1/B2 receptor** antagonist .

HY-P2118

NPC-567	Bradykinin Receptor	Inflammation/Immunology
NPC-567 is a **bradykinin B2 receptor** antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways .

HY-P2109

JMV-1645	Bradykinin Receptor	Inflammation/Immunology
JMV-1645 is a potent and selective B₁ bradykinin receptor antagonist with a K_i value of 0.023 nM on the human cloned B₁ receptor. JMV-1645 can be utilized in trauma and infection research .

HY-100301

FR167344 free base	Bradykinin Receptor	Inflammation/Immunology Endocrinology
FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC₅₀ value of 65 nM and no binding affinity for the B1 receptor.

HY-17446

Icatibant Maximum Cited Publications 10 Publications Verification HOE 140	Bradykinin Receptor	Endocrinology
Icatibant (HOE-140) is a potent and specific peptide antagonist of **bradykinin B2 receptor with IC₅₀ and K_i** of 1.07 nM and 0.798 nM respectively .

HY-108896

Icatibant acetate Maximum Cited Publications 10 Publications Verification HOE 140 acetate	Bradykinin Receptor	Inflammation/Immunology
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of **bradykinin B2 receptor with an IC₅₀ and K_i** of 1.07 nM and 0.798 nM respectively .

HY-106277A

Fasitibant chloride hydrochloride MEN16132	Bradykinin Receptor	Metabolic Disease
Fasitibant chloride hydrochloride (MEN16132) is a potent, selective, high affinity, and long-lasting nonpeptide **bradykinin B₂ (BK₂) receptor** antagonist. Fasitibant chloride hydrochloride has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis .

HY-P1721

NPC 17731	Bradykinin Receptor	Cardiovascular Disease
NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC₅₀ of 23 and 29 nM, respectively .

HY-103289

MEN 11270	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pK_i value of 10.3 .

HY-15039

SSR240612	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
SSR240612 is a potent, and orally active specific non-peptide **bradykinin B1 receptor antagonist, with K_i*s of 0.48 nM and 0.73 nM for B1 kinin* receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively.

HY-106277

Fasitibant free base	Bradykinin Receptor	Metabolic Disease
Fasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide **bradykinin B₂ (BK₂) receptor** antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis .

HY-17446R

Icatibant (Standard)	Bradykinin Receptor	Endocrinology
Icatibant (Standard) is the analytical standard of Icatibant. This product is intended for research and analytical applications. Icatibant (HOE-140) is a potent and specific peptide antagonist of **bradykinin B2 receptor with IC₅₀ and K_i** of 1.07 nM and 0.798 nM respectively .

HY-P1685

Ranatensin	Bombesin Receptor	Endocrinology
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715) .

HY-15791

FR173657 FK-3657	Bradykinin Receptor	Inflammation/Immunology
FR173657 is an orally active **bradykinin B2 receptor antagonist (IC₅₀*: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor* respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED₅₀: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED₅₀: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease .

HY-13716

Noscapine 1 Publications Verification (S,R)-Noscapine	Opioid Receptor Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive *Bradykinin* inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-13716R

Noscapine (Standard)	Opioid Receptor Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .

HY-13716S

Noscapine-13C,d3	Isotope-Labeled Compounds Apoptosis Opioid Receptor	Cancer
Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive *Bradykinin* inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-121550

ME3221	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR), with efficacy comparable to or better than losartan in vivo. ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for treating both renal and essential hypertension similarly to losartan .

HY-15042

MK 0686	Bradykinin Receptor	Metabolic Disease
MK 0686, a potent bradykinin B1 receptor antagonist, demonstrates autoinduction of metabolism in rhesus monkeys after oral administration. It undergoes significant biotransformation primarily via oxidation pathways, leading to the formation of metabolites like M11 and M13 in rhesus liver microsomes. This metabolic induction is mediated by CYP2C75, as evidenced by increased mRNA expression, protein levels, and catalytic activity of this enzyme in hepatocytes and liver microsomes from MK 0686-treated animals. The autoinduction phenomenon suggests that MK 0686 enhances its own metabolism by upregulating CYP2C75, potentially influencing its systemic exposure and pharmacokinetics over time .

Cat. No.	Product Name	Target	Research Area

HY-103290

R715	Bradykinin Receptor	Others
R715 is a selective bradykinin B1 receptor antagonist. R715 significantly attenuates the hyperalgesic effect developed in Streptozotocin(HY-13753)-diabetic mice .

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts .

HY-P0298A

[Des-Arg9]-Bradykinin acetate 1 Publications Verification	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin acetate is a **Bradykinin B₁ receptor** agonist that displays selectivity for B₁ over B₂ receptors.

HY-103295A

Lys-[Des-Arg9]Bradykinin TFA	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective **bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse** and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors .

HY-P4676

Lys-(Des-Arg9,Leu8)-Bradykinin	Bradykinin Receptor	Endocrinology
Lys-(Des-Arg9,Leu8)-Bradykinin is a bradykinin B1 receptor antagonist .

HY-P3209

Des-Arg9-[Leu8]-Bradykinin acetate	Bradykinin Receptor	Inflammation/Immunology
Des-Arg9-[Leu8]-Bradykinin acetate is potent bradykinin receptor 1 (B1R) antagonist. Des-Arg9-[Leu8]-Bradykinin acetate can be used for renal fibrosis research .

HY-P0298

[Des-Arg9]-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
[Des-Arg9]-Bradykinin is a *Bradykinin* (B₁) receptor agonist that displays selectivity for B₁ over B₂ receptors.

HY-103295

Lys-[Des-Arg9]Bradykinin	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective **bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse** and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors .

HY-P5493

D-Arg-[Hyp3,Thi5,8,D-Phe7]-Bradykinin	Peptides	Others
D-Arg-[Hyp3,Thi5,8,D-Phe7]-Bradykinin is a biological active peptide. (inhibited bradykinin-induced contractions concentration dependently; bradykinin B2 receptor antagonist)

HY-103292

[Phe8Ψ(CH-NH)Arg9]-Bradykinin	Bradykinin Receptor	Cardiovascular Disease
[Phe8Ψ(CH-NH)Arg9]-Bradykinin is a selective Bradykinin receptor B₂ agonist (not cleaved by protein kinase I/II). [Phe8Ψ(CH-NH)Arg9]-Bradykinin has potential for the research of hypertension .

HY-P3751

[Tyr8] Bradykinin	Bradykinin Receptor ERK	Cardiovascular Disease Endocrinology
[Tyr8] Bradykinin is a B₂ kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard .

HY-103293A

Lys-Bradykinin TFA Kallidin (380-389) (human, porcine, bovine) TFA	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin (HY-103293). Lys-Bradykinin TFA is a ligand for kallidin and **bradykinin receptor*, which can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin* TFA serves as a vasodilator, which widens blood vessels and increases blood flow. Lys-Bradykinin TFA stimulates net Na+ influx, and contributes to DNA synthesis. Lys-Bradykinin TFA involves in vascular regulation, inflammation and pain sensation .

HY-103293

Lys-Bradykinin Kallidin (380-389) (human, porcine, bovine)	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin, a kind of kallidin and **bradykinin receptor** ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation .

HY-103293B

Lys-Bradykinin tetraacetate Kallidin (380-389) (human, porcine, bovine) tetraacetate	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and **bradykinin receptor** ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation .

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

HY-105155

Lobradimil RMP 7	Bradykinin Receptor	Cancer
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective **bradykinin B2 receptor agonist (K_i**: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors .

HY-P3232

B 9430	Bradykinin Receptor	Inflammation/Immunology Endocrinology
B 9430 is a potent **bradykinin B1/B2 receptor** antagonist .

HY-P5518

[Des-Arg10]-HOE I40	Peptides	Others
[Des-Arg10]-HOE I40 is a biological active peptide. (A potent B1 bradykinin receptor antagonist.)

HY-P2118

NPC-567	Bradykinin Receptor	Inflammation/Immunology
NPC-567 is a **bradykinin B2 receptor** antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways .

HY-P2109

JMV-1645	Bradykinin Receptor	Inflammation/Immunology
JMV-1645 is a potent and selective B₁ bradykinin receptor antagonist with a K_i value of 0.023 nM on the human cloned B₁ receptor. JMV-1645 can be utilized in trauma and infection research .

HY-17446

Icatibant Maximum Cited Publications 10 Publications Verification HOE 140	Bradykinin Receptor	Endocrinology
Icatibant (HOE-140) is a potent and specific peptide antagonist of **bradykinin B2 receptor with IC₅₀ and K_i** of 1.07 nM and 0.798 nM respectively .

HY-108896

Icatibant acetate Maximum Cited Publications 10 Publications Verification HOE 140 acetate	Bradykinin Receptor	Inflammation/Immunology
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of **bradykinin B2 receptor with an IC₅₀ and K_i** of 1.07 nM and 0.798 nM respectively .

HY-P1721

NPC 17731	Bradykinin Receptor	Cardiovascular Disease
NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC₅₀ of 23 and 29 nM, respectively .

HY-103289

MEN 11270	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pK_i value of 10.3 .

HY-17446R

Icatibant (Standard)	Bradykinin Receptor	Endocrinology
Icatibant (Standard) is the analytical standard of Icatibant. This product is intended for research and analytical applications. Icatibant (HOE-140) is a potent and specific peptide antagonist of **bradykinin B2 receptor with IC₅₀ and K_i** of 1.07 nM and 0.798 nM respectively .

HY-P1685

Ranatensin	Bombesin Receptor	Endocrinology
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715) .

HY-103294

R892	Peptides	Others
R892 is a selective and efficient bradyK_inin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13716

Noscapine 1 Publications Verification (S,R)-Noscapine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Inflammation/Immunology Disease Research Fields Papaveraceae	Opioid Receptor Apoptosis
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive *Bradykinin* inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-13716R

Noscapine (Standard)	Structural Classification Alkaloids Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Papaveraceae	Opioid Receptor Apoptosis
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .

Cat. No.	Product Name	Chemical Structure

HY-13716S

Noscapine-13C,d3

Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

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Bradykinin Receptor

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Peptides

NaturalProducts

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