Search Result
Results for "
D 18
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
48
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-144501
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Toll-like Receptor (TLR)
PD-1/PD-L1
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Inflammation/Immunology
Cancer
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D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2 .
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- HY-W038500S
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- HY-135604S
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- HY-W923642
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Endogenous Metabolite
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Sphingomyelin (d18:1/12:0) is a polar lipid with the activity of regulating cell signaling. Sphingomyelin (d18:1/12:0) plays an important role in cell membranes, affecting membrane fluidity and stability. Sphingomyelin (d18:1/12:0) is also involved in lipid metabolism and has the potential to promote neuronal cell growth. Sphingomyelin (d18:1/12:0) plays a key role in the function and development of the nervous system.
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- HY-145472
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Biochemical Assay Reagents
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Cancer
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Sphingosine (d18:1) alkyne (compound 2b) is an alkyne-labeled Sphingosine (d18:1) that can be used in click chemistry reactions .
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- HY-Y1155S
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- HY-153830
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C16 Lactosylceramide (d18:1/16:0)
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Endogenous Metabolite
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Neurological Disease
Metabolic Disease
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LacCer (d18:1/16:0) (C16 Lactosylceramide (d18:1/16:0)) is an endogenous bioactive sphingolipid that can form membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs). The levels of LacCer (d18:1/16:0) are elevated in the plasma of insulin-resistant cattle. In a mouse model of Niemann-Pick type C1 disease (a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder), the expression of LacCer (d18:1/16:0) is also upregulated. LacCer (d18:1/16:0) can be used in research on metabolic diseases and neurodegenerative diseases .
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- HY-17367S1
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- HY-167575
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- HY-156209S
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- HY-164236S
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- HY-173119
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ERK
Autophagy
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Cancer
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SKLB-D18 is a potent and selective inhibitor of ERK1/2 and ERK5, with an IC50 of 38.69, 40.12 and 59.72 nM, respectively. SKLB-D18 is also an autophagy agonist, played a role in mTOR/p70S6K and NCOA4-mediated ferroptosis, which may mitigate multidrug resistance. SKLB-D18 exhibits significantly superior efficacy in vitro and in vivo against triple-negative breast cancer (TNBC) .
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- HY-165075S
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- HY-170035
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C18 Glucosyl(β) ceramide (d18:1/18:0); D-glucosyl-β-1,1' N-stearoyl-D-erythro-sphingosine
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Liposome
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Neurological Disease
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GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a glycosphingolipid. GlcCer (d18:1/18:0) is promising for research of Parkinson disease and dementia with Lewy bodies .
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- HY-158952
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(R)-2'-Hydroxy cer(d18:0/24:0); (R)-2'-Hydroxy ceramide (d18:0/24:0); N-(R)-α-C24 Dihydro ceramide (d18:0/24:0)
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Biochemical Assay Reagents
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Metabolic Disease
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C24 (2'(R)-Hydroxy) dihydro ceramide (d18:0/24:0) ((R)-2'-Hydroxy cer(d18:0/24:0)) is the 2R-isomer of a 2’-hydroxylated form of C24 Dihydro ceramide (d18:0/24:0) (HY-156206).
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- HY-N10706A
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- HY-146929S
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- HY-146933S
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- HY-146932S
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- HY-146901S
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- HY-146930S
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- HY-146931S
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- HY-N8016S
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- HY-134508A
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Biochemical Assay Reagents
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Others
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C24-Ceramide (d18:1/24:0) is a sphingolipid that can be used for the lipid membranes composed. C24-Ceramide (d18:1/24:0) induces time-dependent changes in membrane properties. C24-Ceramide (d18:1/24:0) induces membrane reorganization .
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- HY-145549
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N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine; SM(d18:1/20:0)
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Endogenous Metabolite
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Endocrinology
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C20 Sphingomyelin (d18:1/20:0) (N-eicosanoyl-D-erythro-Sphingosylphosphorylcholine; SM(d18:1/20:0)) is a naturally occurring sphingolipid. C20 Sphingomyelin (d18:1/20:0) levels are upregulated in the hippocampus of streptozotocin (HY-13753)-induced diabetic rats and in human plasma, positively correlating with insulin resistance in obese humans. C20 Sphingomyelin (d18:1/20:0) is also upregulated in the liver of a mouse model of Niemann-Pick C1 disease, a neurodegenerative cholesterol sphingolipid lysosomal storage disorder.
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- HY-145467
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C16 Ceramide-1-phosphate ammonium; Ceramide-1-phosphate (d18:1/16:0) ammonium; CerP(d18:1/16:0) ammonium
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Biochemical Assay Reagents
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Metabolic Disease
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C16 Ceramide-1-phosphate (d18:1/16:0) (ammonium) (C16 Ceramide-1-phosphate (ammonium); Ceramide-1-phosphate (d18:1/16:0) (ammonium)) is an ester product.
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- HY-156209
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- HY-146910S
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- HY-32874S
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- HY-B0803S
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- HY-166226
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- HY-164236
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- HY-165158
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- HY-165075
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- HY-Y1019S
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Isotope-Labeled Compounds
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Others
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Trimethylsilyl N-(trimethylsilyl)acetimidate-d18 is the deuterium labeled Trimethylsilyl N-(trimethylsilyl)acetimidate[1].
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- HY-B0649S1
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- HY-N15352
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Liposome
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Neurological Disease
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C20 Sphingomyelin (d18:1/20:1) (Compound SM:20:1) is a sphingomyelin. C20 Sphingomyelin (d18:1/20:1) is promising for research of motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) .
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- HY-156206
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- HY-164267
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SM (d18:1/14:0)
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Endogenous Metabolite
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Others
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Sphingomyelin (d18:1,C14:0), a major sphingolipid in mammalian cells, increases membrane molecular order .
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- HY-146920S
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Isotope-Labeled Compounds
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Others
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3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d7 (ammonium) is deuterium labeled 3-O-Sulfo-galactosyl(β)sphingosine (d18:1) (ammonium).
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- HY-152020S
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- HY-117081
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Endogenous Metabolite
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Others
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C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .
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- HY-139404
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Anthrylvinyl ceramide; AV Ceramide; AV Ceramide (d18:1/10:0)
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Fluorescent Dye
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Others
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C10 AV Ceramide (d18:1/10:0) is a fluorescent probe. Anthrylvinyl (AV) acts as the fluorescent label positioned on the amide linked acyl chain on the Ceramide molecule to measure the CERT-mediated transfer. The anthrylvinyl moiety of C10 AV Ceramide (d18:1/10:0) localizes to the hydrophobic region of the bilayer .
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- HY-145520
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- HY-158655
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(3'-Sulfo)Galβ-Cer (d18:1/17:0); N-Heptadecanoyl sulfatide; C17 Sulfatide
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Biochemical Assay Reagents
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Neurological Disease
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C17 3'-Sulfo galactosylceramide (d18:1/17:0) is a member of the sulfatide class of glycolipids. C17 3'-Sulfo galactosylceramide (d18:1/17:0) can be used for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies .
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- HY-165032
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(2'(S)-Hydroxy) ceramide (d18:1/24:0); 2'(S)-Hydroxy cer (d18:1/24:0); 24:0(2S-OH) Ceramide
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Biochemical Assay Reagents
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Others
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C24 (2'(S)-Hydroxy) ceramide (d18:1/24:0) is a biochemical reagent.
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- HY-165033
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(2'(R)-Hydroxy) ceramide (d18:1/24:0); 2'(R)-hydroxy cer(d18:1/24:0); 24:0(2R-OH) Ceramide
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Biochemical Assay Reagents
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Others
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C24 (2'(R)-Hydroxy) ceramide (d18:1/24:0) is a biochemical reagent.
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- HY-165062
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Stearoyl sphingomyelin; Sphingomyelin (d18:1/18:0); N-Octadecanoyl sphingosylphosphorylcholine
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Others
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Metabolic Disease
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C18 Sphingomyelin (d18:1/18:0) is a form of sphingomyelin and can be used for study of sphingolipid metabolites .
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- HY-172000
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- HY-W023144S
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Tris(1-chloropropan-2-yl) phosphate-d18
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Isotope-Labeled Compounds
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Others
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Tris(1-chloro-2-propyl) phosphate-d18 (Tris(1-chloropropan-2-yl) phosphate-d18) is a deuterium labeled compound.
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- HY-113934
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L-threo-Sphingosylphosphorylcholine
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LPL Receptor
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Cancer
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L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC50s of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively .
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- HY-W101642S
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- HY-165064
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L-Erythro cer(d18:1/2:0); N-Acetyl-L-erythro-sphingosine; Acetyl-L-erythro-sphingosine
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Others
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Cancer
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C2 L-Erythro ceramide (d18:1/2:0) is a cell-permeable sphingolipid. C2 L-Erythro ceramide (d18:1/2:0) induces cell cycle arrest in the G0/G1 phase and inhibits cell growth .
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- HY-165986
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- HY-116585
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Liposome
Interleukin Related
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Neurological Disease
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C6 D-Threo Ceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable analog of ceramides. C6 D-Threo Ceramide (d18:1/6:0) enhances IL-4 production induced by Phorbol 12-myristate 13-acetate (HY-18739) in EL4 T cells .
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- HY-167595S
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- HY-167596S
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- HY-167598S
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- HY-165087
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- HY-165066
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- HY-155789
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Ceramide trihexoside (d18:1/17:0); Gb3(d18:1)(C17:0)
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Others
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Others
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C17 Globotriaosylceramide (d18:1/17:0) is a sphygosine lipid that can be used to quantify Globotriaosylceramide in plasma and urine of patients with Fabry disease by gas chromatography-mass spectrometry (GC-MS) .
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- HY-115703
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- HY-160850
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Endogenous Metabolite
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Endocrinology
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C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) is a specific type of long-chain molecule found in murine skin . C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) promotes migration of both mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells at concentrations between 0.5-5 µM. C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt)’s levels are higher in CFPAC-1 pancreatic ductal adenocarcinoma cells than in pancreatic cancer stem cells .
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- HY-D0857S
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Isotope-Labeled Compounds
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Others
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HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
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- HY-165031
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16:0 (2S-OH)-Ceramide; 2'-Hydroxy C16-ceramide; 2'(S)-Hydroxy cer(d18:1/16:0)
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Biochemical Assay Reagents
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Others
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C16 (2'(S)-Hydroxy) ceramide (d18:1/16:0) is a biochemical reagent.
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- HY-167597S
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- HY-124177A
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- HY-167599S
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- HY-165072
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C2 Sulfatide; N-Acetyl sulfatide
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Others
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Others
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C2 3'-Sulfo galactosylceramide (d18:1/2:0) (C2 Sulfatide) is one of the sulfatide class of glycolipids. C2 3'-Sulfo galactosylceramide (d18:1/2:0) can be used in the quantification of lysosulfatides in mouse brain tissue and plasma .
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- HY-B2015S
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Cytochrome P450
Parasite
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Infection
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Carbosulfan-d18 is the deuterium labeled Carbosulfan. Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.
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- HY-W341625
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Biochemical Assay Reagents
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Inflammation/Immunology
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Trihexosylceramide (d18:1/12:0) is a type of Trihexosylceramide. In the renal tissue of heterozygous Fabry's disease, the cytoplasm of glomerular epithelial cells appears foamy. Trihexosylceramide accumulated in glomerular epithelial cells as identified by immunostaining .
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- HY-115420
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- HY-N11142
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- HY-118358
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- HY-W001187S
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DNA/RNA Synthesis
Mitochondrial Metabolism
Reactive Oxygen Species
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Cancer
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Tempo-d18 is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].
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- HY-124273
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L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0); N-acetyl-L-threo-Sphingosine
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Endogenous Metabolite
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Cardiovascular Disease
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C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0)) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.
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- HY-D0875S
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1,4-Piperazinediethanesulfonic acid-d18
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Isotope-Labeled Compounds
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PIPES-d18 is the deuterium labeled PIPES[1]. PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry[2].
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- HY-169795
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Apoptosis
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Cancer
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C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that can effectively induce apoptosis in U937 cells and cause fragmentation of nucleosomal DNA .
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- HY-W288788S
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- HY-139393
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- HY-158803
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C6 Glucosylceramide-biotin; N-Hexanoyl-biotin-glucosylceramide
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Biochemical Assay Reagents
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Metabolic Disease
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C6 Biotin glucosylceramide (d18:1/6:0) (C6 Glucosylceramide-biotin; N-Hexanoyl-biotin-glucosylceramide) is an ester product.
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- HY-131113S
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N-Nitroso-di-n-butylamine-d18
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Isotope-Labeled Compounds
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Others
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N-Nitrosodibutylamine-d18 is the deuterium labeled N-Nitrosodibutylamine[1]. N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water[2].
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- HY-N11142S
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C18 Globotriaosylceramide-d7 (d18:1/18:0)
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Isotope-Labeled Compounds
Others
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Metabolic Disease
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Gb3-d7 (18:1/18:0) (C18 Globotriaosylceramide-d7 (d18:1/18:0)) is deuterium labeled Gb3(18:1/18:0). Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product .
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- HY-165034
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((±)-2'-Hydroxy) cer(d18:1/18:0); 18:0 (2R/S-OH)-Ceramide; ((±)-2'-Hydroxy) ceramide (d18:1/18:0)
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Endogenous Metabolite
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Others
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C18 ((±)-2'-Hydroxy) ceramide ((±)-2'-Hydroxy) cer) (d18:1/18:0) is a bioactive sphingolipid found in the stratum corneum layer of mammalian epidermis. Ceramides maintains the normal hydration levels required for the normal physiological .
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- HY-139261
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- HY-13017S2
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VX-770-d18
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Autophagy
CFTR
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Endocrinology
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Ivacaftor-d18 is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2].
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- HY-131992
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C2 Galactosylceramide (d18:1/2:0)
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Apoptosis
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Inflammation/Immunology
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N-Acetylpsychosine (C2 Galactosylceramide (d18:1/2:0)), α-galactosylated C2-ceramide, has immunostimulatory activity. N-Acetylpsychosine can be a useful tool to investigate the mechanism of apoptosis and the immune reponses induced by dendritic cells (DCs) .
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- HY-N10634
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C16 Glucosyl(β) Ceramide (d18:1/16:0)
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Others
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Inflammation/Immunology
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D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .
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- HY-158873
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- HY-165650S
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C16 GM1-d9; N-Hexadecaoyl-d9 (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1
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Isotope-Labeled Compounds
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Others
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C16 Ganglioside GM1-d9 (d18:1/16:0-d9) (C16 GM1-d9) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium salt) .
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- HY-165069
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Sphingomyelin (d18:1 C22:0)
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Others
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Others
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N-Docosanoyl-D-erythro-sphingosylphosphorylcholine (Sphingomyelin (d18:1 C22:0)) is a compound that appears in the plasma sphingolipid profile after chronic hepatitis C virus infection. The level of this substance in plasma is associated with hepatic steatosis and may be an independent factor of hepatic steatosis.
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- HY-154831
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N-Behenoyl-D-erythro-sphingosine; Cer d18:1/22:0
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Liposome
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Metabolic Disease
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C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .
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- HY-165676AS
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C16 GM2-dN; N-CDN-Palmitoyl-GM2, N-Hexadecaoyl-dN (13,13,14,14,15,15,16,16,16)-Moosialogaglioside GM2; N-Palmitoyl Moosialogaglioside GM2-d9
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Isotope-Labeled Compounds
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Others
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C16 Ganglioside GM2-d9 (d18:1/16:0-d9) (C16 GM2-d9) ammonium saltis deuterium labeled C16 Ganglioside GM2 (d18:1/16:0) (ammonium salt) .
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- HY-W015829S
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Tetramethylpropylenediamine-d18
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Isotope-Labeled Compounds
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Others
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N1,N1,N3,N3-Tetramethylpropane-1,3-diamine-d18 is the deuterium labeled N1,N1,N3,N3-Tetramethylpropane-1,3-diamine[1].
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- HY-N10634S
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N-ω-CD3-Hexadecaoyl-glucopsychosie; GluCe(d18:1/16:0-d3); Glucosylceamide-d3 (d18:1/16:0-d3)
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Isotope-Labeled Compounds
Others
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Inflammation/Immunology
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D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-Cd3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine. D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .
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- HY-158657
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Biochemical Assay Reagents
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Others
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3-Keto-C12-dihydrosphingosine hydrochloride is a short-chain analog of the typical C18 chain-length 3-keto sphinganine (d18:0) .
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- HY-139062
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C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea; D-erythro-Urea-C6-Ceramide
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Apoptosis
Ceramidase
Autophagy
β-catenin
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Cancer
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C6 Urea Ceramide (Cer(d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. C6 Urea Ceramide increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells. C6 Urea Ceramide (5-10 μM) inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but is not toxic to non-cancerous cells. C6 Urea Ceramide decreases total and phosphorylated β-catenin levels in HT-29 and HCT116 cells, and induces colocalization of β-catenin with the 20S proteasome. C6 Urea Ceramide (1.25, 2.5, and 5 mg/kg) reduced tumor growth and increased C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.
|
-
- HY-152017S
-
-
- HY-142975
-
|
C15 Galactosylceramide (d18:1/15:0); GalCer(d18:1/15:0)
|
Endogenous Metabolite
|
Others
|
|
N-Pentadecanoyl-psychosine is a glycolipid that can be used in membrane adhesion studies .
|
-
- HY-W019838
-
-
- HY-139286
-
|
Pacsph; Pacsphingosine (d18:1)
|
Biochemical Assay Reagents
|
Others
|
|
Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .
|
-
- HY-20390S
-
-
- HY-131676
-
|
SM (d18:1/17:0); Heptadecanoyl Sphingomyelin; N-Heptadecanoyl-D-erythro-Sphingosylphosphorylcholine
|
Endogenous Metabolite
|
Metabolic Disease
|
|
C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin.
|
-
- HY-152021S
-
-
- HY-145535
-
|
C24 3'-sulfo Galactosylceramide (d18:1/24:0)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Tetracosanoyl-sulfatide is an endogenous metabolite present in Urine that can be used for the research of Mild Metachromatic Leukodystrophy .
|
-
- HY-W019838S
-
-
- HY-W747533
-
|
C8 Ceramine; Ceramine (d18:1/8:0)
|
Drug Derivative
|
Others
|
|
C8 Ceramine is an analog of ceramide in which the carbonyl group of the ceramide is replaced by a methylene group. At a concentration of 10 μM, C8 ceramine induces maximal DNA fragmentation in U937 cells after 6 hours of incubation, compared to 12 hours for C8 ceramide.
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-
- HY-N9410S
-
|
1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC-d9
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Lysophosphatidylcholine 18:2-d9 is deuterium labeled Lysophosphatidylcholine 18:2. Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary
|
-
- HY-141580S1
-
|
N-octadecaoyl-D-eytho-Dihydosphigosie-d3; Ce(d18:0/18:0)-d3; Ceamide-d3 (d18:0/18:0-d3)
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
C18 Dihydroceramide-d3-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d3) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product .
|
-
- HY-125726
-
|
(3'-sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide
|
Nuclear Factor of activated T Cells (NFAT)
|
Inflammation/Immunology
|
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Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.
|
-
- HY-166876S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Nicergoline impurity 18-d4 is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .
|
-
- HY-152022S
-
-
- HY-154802
-
|
|
ADC Linker
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2 . TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-154831
-
|
N-Behenoyl-D-erythro-sphingosine; Cer d18:1/22:0
|
Drug Delivery
|
|
C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .
|
-
- HY-167575
-
|
|
Drug Delivery
|
|
Sphingosyl PE (d18:1) is a kind of biochemical reagent.
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Compare |
Product Name |
Species |
Source |
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| Products |
| Cat. No. |
| Species |
| Source |
| Tag |
| Accession |
| Gene ID |
| Molecular Weight |
| Purity |
| Endotoxin Level |
| Biological Activity |
| Appearance |
| Formulation |
| Storage & Stability |
| Shipping |
| Free Sample |
| Size |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-W038500S
-
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|
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Hexamethylbenzene-d18 is the deuterium labeled Hexamethylbenzene[1].
|
-
-
- HY-135604S
-
|
|
|
Dibutyl Phosphate-d18 is a deuterium labeled compound.
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-
-
- HY-Y1155S
-
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|
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Hexamethylphosphoramide-d18 is the deuterium labeled Hexamethylphosphoramide[1].
|
-
-
- HY-17367S1
-
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|
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Atazanavir-d18 is the d18 labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .
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-
-
- HY-156209S
-
|
|
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Gb3(d18:1/16:0)-d9 is deuterium labeled Gb3(d18:1/16:0). Gb3(d18:1/16:0) is an ester product .
|
-
-
- HY-164236S
-
|
|
|
C22 Glucosylceramide (d18:1/22:0)-d4 is deuterium labeled C22 Glucosylceramide (d18:1/22:0). C22 Glucosylceramide (d18:1/22:0) is an ester product .
|
-
-
- HY-165075S
-
|
|
|
C26 Sphingomyelin (d18:1/26:0)-d4 is deuterium labeled C26 Sphingomyelin (d18:1/26:0). C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.
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-
-
- HY-146929S
-
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|
|
18:1 SM (d18:1/18:1)-d9 is deuterium labeled 18:1 SM (d18:1/18:1).
|
-
-
- HY-146933S
-
|
|
|
24:1 SM (d18:1/24:1)-d9 is deuterium labeled 24:1 SM (d18:1/24:1).
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-
-
- HY-146932S
-
|
|
|
22:1 SM (d18:1/22:1)-d9 is deuterium labeled 22:1 SM (d18:1/22:1).
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-
-
- HY-146901S
-
|
|
|
15:0 SM (d18:1/15:0)-d9 is deuterium labeled 15:0 SM (d18:1/15:0).
|
-
-
- HY-146930S
-
|
|
|
16:1 SM (d18:1/16:1)-d9 is deuterium labeled 16:1 SM (d18:1/16:1).
|
-
-
- HY-146931S
-
|
|
|
20:1 SM (d18:1/20:1)-d9 is deuterium labeled 20:1 SM (d18:1/20:1).
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-
-
- HY-N8016S
-
|
|
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Nonanal-d18 is the deuterium labeled Nonanal[1]. Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity[2].
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-
-
- HY-146910S
-
|
|
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CER1 (d18:1/26:0/18:1)-d9 is deuterium labeled CER1 (d18:1/26:0/18:1).
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-
-
- HY-32874S
-
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|
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1,9-Dibromononane-d18 is the deuterium labeled 1,9-Dibromononane[1].
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-
-
- HY-B0803S
-
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|
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Lumefantrine-d18 is the deuterium labeled Lumefantrine, which is an antimalarial agent.
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-
-
- HY-Y1019S
-
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|
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Trimethylsilyl N-(trimethylsilyl)acetimidate-d18 is the deuterium labeled Trimethylsilyl N-(trimethylsilyl)acetimidate[1].
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-
-
- HY-B0649S1
-
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|
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Propofol-d18 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission[1].
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-
-
- HY-146920S
-
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|
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3-O-Sulfo-galactosyl(β)sphingosine (d18:1)-d7 (ammonium) is deuterium labeled 3-O-Sulfo-galactosyl(β)sphingosine (d18:1) (ammonium).
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-
-
- HY-152020S
-
|
|
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Sphingosine-d9 (d18:1) (D-eytho-Sphigosie C18-d9) is deuterium labeled Sphingosine (d18:1) .
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-
-
- HY-W023144S
-
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|
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Tris(1-chloro-2-propyl) phosphate-d18 (Tris(1-chloropropan-2-yl) phosphate-d18) is a deuterium labeled compound.
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-
-
- HY-W101642S
-
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|
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1,3-Diisopropylbenzene-d18 is the deuterium labeled 1,3-Diisopropylbenzene[1].
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-
-
- HY-167595S
-
|
|
|
C18:0-d7 GD3 Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GD3 Ceramide (d18:1/18:0) .
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-
-
- HY-167596S
-
|
|
|
C18:0-d7 GD2 Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GD2 Ceramide (d18:1/18:0) .
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-
-
- HY-167598S
-
|
|
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C18:0-d7 GB4 Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GB4 Ceramide (d18:1/18:0) .
|
-
-
- HY-D0857S
-
1 Publications Verification
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|
HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
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-
-
- HY-167597S
-
|
|
|
C18:0-d7 GD1b Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 GD1b Ceramide (d18:1/18:0) .
|
-
-
- HY-167599S
-
|
|
|
C18:0-d7 Fuc-GM1 Ceramide (d18:1/18:0-d7) is deuterium labeled C18:0 Fuc-GM1 Ceramide (d18:1/18:0) .
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-
-
- HY-B2015S
-
|
|
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Carbosulfan-d18 is the deuterium labeled Carbosulfan. Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.
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-
-
- HY-W001187S
-
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|
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Tempo-d18 is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].
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-
-
- HY-D0875S
-
|
|
|
PIPES-d18 is the deuterium labeled PIPES[1]. PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry[2].
|
-
-
- HY-W288788S
-
|
|
|
5-Methylheptan-3-ol-d18 is the deuterium labeled 5-Methylheptan-3-ol[1].
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-
-
- HY-131113S
-
|
|
|
N-Nitrosodibutylamine-d18 is the deuterium labeled N-Nitrosodibutylamine[1]. N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water[2].
|
-
-
- HY-N11142S
-
|
|
|
Gb3-d7 (18:1/18:0) (C18 Globotriaosylceramide-d7 (d18:1/18:0)) is deuterium labeled Gb3(18:1/18:0). Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product .
|
-
-
- HY-13017S2
-
|
|
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Ivacaftor-d18 is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2].
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-
-
- HY-165650S
-
|
|
|
C16 Ganglioside GM1-d9 (d18:1/16:0-d9) (C16 GM1-d9) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium salt) .
|
-
-
- HY-165676AS
-
|
|
|
C16 Ganglioside GM2-d9 (d18:1/16:0-d9) (C16 GM2-d9) ammonium saltis deuterium labeled C16 Ganglioside GM2 (d18:1/16:0) (ammonium salt) .
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-
-
- HY-W015829S
-
|
|
|
N1,N1,N3,N3-Tetramethylpropane-1,3-diamine-d18 is the deuterium labeled N1,N1,N3,N3-Tetramethylpropane-1,3-diamine[1].
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-
-
- HY-N10634S
-
|
|
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D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-Cd3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine. D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .
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-
-
- HY-152017S
-
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|
|
C18 Globotriaosylceramide-d3 is deuterium labeled Gb3(18:1/18:0). Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product .
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-
-
- HY-20390S
-
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Lapatinib impurity 18-d4 is deuterium labeled 3-Chloro-4-((3-fluorobenzyl)oxy)aniline.
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- HY-152021S
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-
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- HY-W019838S
-
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D-Erythro-dihydrosphingosine-d7 is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
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-
-
- HY-N9410S
-
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|
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Lysophosphatidylcholine 18:2-d9 is deuterium labeled Lysophosphatidylcholine 18:2. Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary
|
-
-
- HY-141580S1
-
|
|
|
C18 Dihydroceramide-d3-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d3) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product .
|
-
-
- HY-166876S
-
|
|
|
Nicergoline impurity 18-d4 is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .
|
-
-
- HY-152022S
-
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-145472
-
|
|
|
Alkynes
|
|
Sphingosine (d18:1) alkyne (compound 2b) is an alkyne-labeled Sphingosine (d18:1) that can be used in click chemistry reactions .
|
-
- HY-139286
-
|
Pacsph; Pacsphingosine (d18:1)
|
|
Alkynes
|
|
Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .
|
-
- HY-154802
-
|
|
|
TCO
ADC Synthesis
|
|
TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2 . TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
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