Dd2

By Targets:	Antibiotic (1) Bacterial (1) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (2) Insecticide (1) Parasite (15)
By Research Areas:	Cancer (1) Infection (17)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111746

CWHM-1008 1 Publications Verification	Parasite	Infection
CWHM-1008 is a potent and orally active antimalarial agent, with EC₅₀ values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively .

HY-123561

MMV008138	Parasite	Infection
MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC₅₀ of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC₅₀ of 250 nM ^[2].

HY-W112166A

4,4'-Dicyanostilbene	Bacterial	Infection
4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC₅₀ of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA) .

HY-161170

Antimalarial agent 36	Parasite	Infection
Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC₅₀s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets *EphA2* .

HY-116736

BRD7539	Dihydroorotate Dehydrogenase Parasite	Infection
BRD7539 is a PfDHODH inhibitor (IC₅₀ = 0.033 μM). BRD7539 has potent activity against both multidrug-resistant asexual blood-stage (P. falciparum, Dd2 strain, EC₅₀ = 0.010 μM) and liver-stage (P. berghei, EC₅₀ = 0.015 μM) parasites .

HY-W112166

(E/Z)-4,4'-Dicyanostilbene	Others	Infection
(E/Z)-4,4'-Dicyanostilbene is the isomer of 4,4'-Dicyanostilbene (HY-W112166A), and can be used as an experimental control. 4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC₅₀ of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA) .

HY-128354

CWHM-1552	Parasite	Infection
CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC₅₀s of 51 nM and 53 nM for 3D7 and *Dd2* strain, respectively .

HY-146769

Antimalarial agent 11	Parasite	Infection
Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC₅₀ of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC₅₀s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively .

HY-119714

Ambelline	Parasite	Infection
Ambelline is an alkaloid that can be isolated from the Amaryllidaceae family. Ambelline shows antimalarial activity against Dd2 P. falciparum strain, with an IC₅₀ of 7.3 ± 0.3 μM ^[2].

HY-116552

KAR425	Parasite	Infection
KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC₅₀ values of 62 nM, 55 nM, and 60 nM, respectively .

HY-159963

PfCLK3-IN-1	Parasite	Infection
PfCLK3-IN-1 (Compound 4) is a covalent inhibitor for Plasmodium falciparum CLK3 (Pf CLK3) under alkaline conditions with an pEC₅₀ of 7.1. PfCLK3-IN-1 reduces mature gametocytes in sexual stage parasites, and prevents transmission. PfCLK3-IN-1 inhibits P. falciparum Dd2-B2 clone with an IC₅₀ of 239.5 nM .

HY-13836

ELQ-300	Parasite	Infection
ELQ-300 is a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Q_i) site of the cytochrome bc₁ complex (cyt bc₁). ELQ-300 inhibits growth of P. falciparum Dd2, Tm90-C2B, and D1 with IC₅₀ values of 6.6, 4.6 and 160 nM, respectively. ELQ-300 can be used for the research of antimalarial ^[2].

HY-134914

Fosmidomycin	Antibiotic Parasite	Infection
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC₅₀s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .

HY-120462

Genz-669178	Dihydroorotate Dehydrogenase Parasite	Infection
Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC₅₀ of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC₅₀ of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED₅₀ of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice .

HY-143487

Antimalarial agent 12	Parasite	Infection
Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC₅₀=155 nM), 3D7 strain (EC₅₀=136 nM). Antimalarial agent 12 has CC₅₀ values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli .

HY-W437569

Melicopine	Parasite Insecticide	Infection Cancer
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC₅₀ values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC₅₀ values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC₅₀ greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields .

HY-18572S1

2,4-D-d3	DNA/RNA Synthesis	Others
2,4-D-d₃ is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].

HY-18572S2

2,4-D-d5	DNA/RNA Synthesis	Others
2,4-D-d₅ is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage ^[2].

Cat. No.	Product Name	Target	Research Area

HY-P5499

CMV pp65(13-27)	Peptides	Others
CMV pp65(13-27) is a biological active peptide. (This peptide is derived from amino acid residues 13 to 27 of the 65k lower matrix phosphoprotein of the human cytomegalovirus. It contains a nine-amino-acid sequence (LGPISGHVL) that matches the consensus binding motif for a major histocompatibility complex H2-Dd T-cell epitope.)

Cat. No.	Product Name	Target	Research Area

HY-P990193

Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S)	Inhibitory Antibodies	Others
Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse MHC Class I.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-134914

Fosmidomycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Parasite
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC₅₀s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .

HY-W437569

Melicopine	Structural Classification Alkaloids Cornaceae Cornus officinalis Sieb. et Zucc. Source classification Acridone Alkaloids Plants	Parasite Insecticide
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC₅₀ values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC₅₀ values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC₅₀ greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75520

	AKR1C2 Protein, Human (His) AKR-1C2; Aldo-keto reductase family 1 member C2; Dd-2; AKR1C2	Human	E. coli
	AKR1C2 protein: Cytoplasmic aldehyde-keto reductase, which uses NADH and NADPH to reduce ketosteroids to hydroxysteroids. AKR1C2 Protein, Human (His) is the recombinant human-derived AKR1C2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of AKR1C2 Protein, Human (His) is 323 a.a., with molecular weight of ~38 kDa.

HY-P7469

	AKR1C2 Protein, Human rHuAldo-keto reductase family 1 member C2; AKR-1C2; Aldo-keto reductase family 1 member C2	Human	E. coli
	AKR1C2 Protein, Human is a recombinant human AKR1C2. AKR1C2 is a member of the aldo/keto reductase superfamily and has critical roles in the tumorigenesis and progression of malignant tumours.

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Cat. No.	Product Name	Chemical Structure

HY-18572S2

2,4-D-d5
2,4-D-d₅ is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].

HY-18572S1

2,4-D-d3
2,4-D-d₃ is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].

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Dd2

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