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EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .
CALP3, a Ca 2+-like peptide, is a potent Ca 2+ channel blocker that activates EF hand motifs of Ca 2+-binding proteins. CALP3 can functionally mimic increased [Ca 2+]i by modulating the activity of Calmodulin (CaM), Ca 2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .
Elf18 is the bacterial N-terminal fragment of Elongation Factor Thermus (EF-Tu). Elf18 is recognized by pattern recognition receptors (PRRs) as a pathogen-associated molecular pattern (PAMP), and thus induces immune response in Arabidopsis .
EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy .
CALP3 TFA, a Ca 2+-like peptide, is a potent Ca 2+ channel blocker that activates EF hand motifs of Ca 2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca 2+]i by modulating the activity of Calmodulin (CaM), Ca 2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .
Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces collinus Tu 365. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome .
ERBB agonist-1 (Compound EF-1) is an agonist for ERBB4, that activates the ERBB4 signaling pathway by inducing dimerization of the ERBB4 receptor with an EC50 of 10.5 μM. ERBB agonist-1 induces phosphorylation of Akt and ERK1/2, reduces the collagen expression in cardiac fibroblasts, inhibits H2O2-induced cardiomyocyte death and Ang II (HY-13948)-induced cardiomyocyte hypertrophy. ERBB agonist-1 prevents fibrosis and exhibits cardioprotective efficacy in mouse models .
Fusidic acid-d6 is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].
Fusidic acid (Standard) is the analytical standard of Fusidic acid. This product is intended for research and analytical applications. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome. Fusidic acid holds promise for research in anticancer and anti-infective applications. .
Fusidic acid (sodium salt) (Standard) is the analytical standard of Fusidic acid (sodium salt). This product is intended for research and analytical applications. Fusidic acid sodium salt (Sodium fusidate), a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid sodium salt has no corticosteroid effects. Fusidic acid sodium salt inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaMEF-hand/Ca 2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca 2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .
LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively .
CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 µM) with high affinity for binding to the CaMEF-hand/Ca 2+-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca 2+ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .
Schnurri-3 inhibitor-1 is a potent schnurri-3 inhibitor which is an essential regulator of adult bone formation. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in osteoblast cell line Shn3FFL with an AC50 value of 2.09 μM. Schnurri-3 inhibitor-1 can be used to research osteoporosis .
CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaMEF-hand/Ca 2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .
CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaMEF-hand/Ca 2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .
Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice .
Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC50: 0.30 μM). Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research .
CALP3, a Ca 2+-like peptide, is a potent Ca 2+ channel blocker that activates EF hand motifs of Ca 2+-binding proteins. CALP3 can functionally mimic increased [Ca 2+]i by modulating the activity of Calmodulin (CaM), Ca 2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .
Elf18 is the bacterial N-terminal fragment of Elongation Factor Thermus (EF-Tu). Elf18 is recognized by pattern recognition receptors (PRRs) as a pathogen-associated molecular pattern (PAMP), and thus induces immune response in Arabidopsis .
CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 µM) with high affinity for binding to the CaMEF-hand/Ca 2+-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca 2+ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .
CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaMEF-hand/Ca 2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .
CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaMEF-hand/Ca 2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .
CALP3 TFA, a Ca 2+-like peptide, is a potent Ca 2+ channel blocker that activates EF hand motifs of Ca 2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca 2+]i by modulating the activity of Calmodulin (CaM), Ca 2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .
CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaMEF-hand/Ca 2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca 2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .
Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome. Fusidic acid holds promise for research in anticancer and anti-infective applications. .
Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice .
Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces collinus Tu 365. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome .
Fusidic acid (Standard) is the analytical standard of Fusidic acid. This product is intended for research and analytical applications. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
Fusidic acid (sodium salt) (Standard) is the analytical standard of Fusidic acid (sodium salt). This product is intended for research and analytical applications. Fusidic acid sodium salt (Sodium fusidate), a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid sodium salt has no corticosteroid effects. Fusidic acid sodium salt inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome .
EEF1B2 Protein facilitates GDP-to-GTP exchange on EEF1A Protein, driving the conversion. EEF1 comprises four subunits: alpha, beta, delta, and gamma. EEF1B2 Protein, Human (His) is the recombinant human-derived EEF1B2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of EEF1B2 Protein, Human (His) is 224 a.a., with molecular weight of ~29 kDa.
EEF1A1 is a translation elongation factor that catalyzes GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the ribosomal A site during protein synthesis. This involves mRNA codon-aa-tRNA anticodon base pairing, leading to GTP hydrolysis and aa-tRNA release in EEF1A1. EEF1A1 Protein, Human (His-SUMO) is the recombinant human-derived EEF1A1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of EEF1A1 Protein, Human (His-SUMO) is 462 a.a., with molecular weight of ~66.1 kDa.
The RCN3 protein is a possible molecular chaperone that contributes to endoplasmic reticulum protein biosynthesis and transport. RCN3 is critical for pulmonary surfactant homeostasis and is required for the correct biosynthesis and transport of SP-A, SP-D, and ABCA3. RCN3 Protein, Human (HEK293, His) is the recombinant human-derived RCN3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of RCN3 Protein, Human (HEK293, His) is 308 a.a., with molecular weight of ~43.0 kDa.
RCN3 Protein, a probable molecular chaperone, ensures pulmonary surfactant homeostasis by aiding in proper biosynthesis and transport of SP-A, SP-D, and ABCA3. It exhibits anti-fibrotic activity by negatively regulating type I and type III collagen secretion. RCN3 transiently associates with immature PCSK6, suggesting its role in PCSK6 maturation and secretion. RCN3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived RCN3 protein, expressed by HEK293 , with C-His labeled tag. The total length of RCN3 Protein, Mouse (HEK293, His) is 308 a.a., with molecular weight of ~36.9 KDa.
The RCN3 protein is a possible molecular chaperone critical for protein biosynthesis and transport within the endoplasmic reticulum. Its involvement extends to the biosynthesis and transport of key proteins, including SP-A, SP-D, and ABCA3, highlighting the importance of pulmonary surfactant homeostasis. RCN3 Protein, Rat (HEK293, His) is the recombinant rat-derived RCN3 protein, expressed by HEK293 , with C-His labeled tag. The total length of RCN3 Protein, Rat (HEK293, His) is 304 a.a., with molecular weight of ~36.4 KDa.
PLA2G2A Protein, a phospholipase A2 enzyme, efficiently hydrolyzes phosphatidylethanolamines and phosphatidylglycerols, contributing to lipid membrane remodeling and generating lipid mediators crucial for pathogen clearance.PLA2G2A Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PLA2G2A protein, expressed by P.pastoris , with C-His labeled tag.
The PLA2G2A protein is a secreted calcium-dependent phospholipase A2 that selectively targets extracellular phospholipids and contributes to host antimicrobial defense, inflammation, and tissue regeneration. It has phospholipase A2 activity, which preferentially hydrolyzes fatty acyl groups, phosphatidylethanolamine and phosphatidylglycerol. PLA2G2A Protein, Human (HEK293, His) is the recombinant human-derived PLA2G2A protein, expressed by HEK293 , with C-His labeled tag.
rHuCell growth regulator with EF hand domain protein 1/CGREF1, His; Cell Growth Regulator with EF Hand Domain Protein 1; Cell Growth Regulatory Gene 11 Protein; Hydrophobestin; CGREF1; CGR11
FAM3D protein is part of the FAM3 family and plays an important role in cell signaling as a transmembrane ligand in the ephrin family.FAM3D interacts with its Eph receptor, initiates bidirectional signaling, regulates multiple cellular processes in development, and is involved in tissue boundary formation, axon guidance, angiogenesis, and synaptic plasticity.FAM3D Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FAM3D protein, expressed by HEK293 , with C-hFc labeled tag.
FAM3D protein is part of the FAM3 family and plays an important role in cell signaling as a transmembrane ligand in the ephrin family.FAM3D interacts with its Eph receptor, initiates bidirectional signaling, regulates multiple cellular processes in development, and is involved in tissue boundary formation, axon guidance, angiogenesis, and synaptic plasticity.FAM3D Protein, Mouse (HEK293, His) is the recombinant mouse-derived FAM3D protein, expressed by HEK293 , with C-10*His labeled tag.
Fusidic acid-d6 is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].
Elongation factor 2 Antibody (YA962) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA962), targeting Elongation factor 2, with a predicted molecular weight of 95 kDa (observed band size: 95 kDa). Elongation factor 2 Antibody (YA962) can be used for WB, ICC/IF, ChIP experiment in human background.
Elongation factor 2 Antibody (YA964) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA964), targeting Elongation factor 2, with a predicted molecular weight of 95 kDa (observed band size: 95 kDa). Elongation factor 2 Antibody (YA964) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
Elongation Factor 1A1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 50 kDa, targeting to Elongation Factor 1A1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.
Calumenin Antibody (YA813) is a non-conjugated and Mouse origined monoclonal antibody about 37 kDa, targeting to Calumenin (4C6). It can be used for WB assays with tag free, in the background of Human, Mouse.
Elongation factor 2 Antibody (YA963) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA963), targeting Elongation factor 2, with a predicted molecular weight of 95 kDa (observed band size: 95 kDa). Elongation factor 2 Antibody (YA963) can be used for WB, ICC/IF experiment in human, mouse, monkey, rat background.
Phospho-Elongation Factor 2 (Thr56/Thr58) Antibody (YA2581) is a non-conjugated IgG antibody, targeting Phospho-Elongation Factor 2 (Thr56/Thr58), with a predicted molecular weight of 95 kDa (observed band size: 95 kDa). Phospho-Elongation Factor 2 (Thr56/Thr58) Antibody (YA2581) can be used for WB experiment in human background.
Elongation factor 1 gamma Antibody (YA2004) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2004), targeting Elongation factor 1 gamma, with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Elongation factor 1 gamma Antibody (YA2004) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
Elongation Factor 1A2 Antibody (YA2879) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2879), targeting Elongation Factor 1A2, with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Elongation Factor 1A2 Antibody (YA2879) can be used for WB, IP experiment in human, mouse, rat background.
PEF1 Antibody (YA1572) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1572), targeting PEF1, with a predicted molecular weight of 30 kDa (observed band size: 30 kDa). PEF1 Antibody (YA1572) can be used for WB, IP experiment in human, mouse, rat background.
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