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Fibronectin protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FAK (1) Glutaminase (1) Integrin (2) Interleukin Related (1) JNK (2) PROTACs (1) Src (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3160

Fibronectin 4 Publications Verification	Integrin	Cardiovascular Disease Inflammation/Immunology
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

HY-170601

PROTAC JNK1-targeted-1	PROTACs JNK	Cancer
PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader, with a DC₅₀ of 10 nM. PROTAC JNK1-targeted-1 (PA2) decreases the level of Fibronectin protein. PROTAC JNK1-targeted-1 can be used for the research of pulmonary fibrosis . (Pink: JNK1 inhibitor (HY-170602); Black: linker (HY-40178); Blue: CRBN Ligand (HY-41547))

HY-102073

TG53	Glutaminase Integrin FAK Src	Cancer
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research .

HY-P99479

Bifikafusp alfa L19-IL2	Interleukin Related	Cancer
Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity .

HY-169177

JNK-1-IN-4	JNK	Inflammation/Immunology
JNK-1-IN-4 (Compound E1) is an inhibitor for JNK, that inhibits JNK-1, JNK-2 and JNK-3 with IC₅₀s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun, and reduces the expression of TGF-β1-induced EMT marker proteins, such as fibronectin and α-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin (HY-17565)-induced mice idiopathic pulmonary fibrosis models .

Cat. No.	Product Name	Type

HY-P3160

Fibronectin 4 Publications Verification	Native Proteins
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

Cat. No.	Product Name	Target	Research Area

HY-P99479

Bifikafusp alfa L19-IL2	Interleukin Related	Cancer
Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity .

Fibronectin 4 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Integrin
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

Species:	Human (19) Rat (3) Mouse (3)
Tag:	His (13) Tag Free (3) Avi (2) Fc (3)
Source:	HEK293 (15) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P70593

	Fibronectin Protein, Human 5 Publications Verification NovoNectin; Fibronectin; FN; Cold-insoluble globulin; CIG; FN; Fibronectin 1	Human	E. coli
	Fibronectin is a glycoprotein located in the extracellular matrix that can bind to collagen, fibrin, heparin, DNA, and actin. Fibronectin is involved in cell adhesion, movement, conditioning, wound healing, and maintaining cell shape. Additionally, by binding to the LILRB4 receptor, Fibronectin can inhibit monocyte activation mediated by FCGR1A/CD64, thereby exerting immune regulatory effects. Human Fibronectin is a recombinant protein dimer complex with a full length of 573 amino acids (P1270-S1546 & A1721-T2016), expressed in E. coli and is untagged.

HY-P72370

	Fibronectin Protein, Human (Biotinylated, His-Avi) Fibronectin; FN1	Human	E. coli
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. Fibronectin Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived Fibronectin protein, expressed by E. coli , with N-Avi, N-6*His labeled tag. The total length of Fibronectin Protein, Human (Biotinylated, His-Avi) is 91 a.a., with molecular weight of ~13.0 kDa.

HY-P73063

	Fibronectin Protein, Human (HEK293, His) 1 Publications Verification Fibronectin; FN; Cold-insoluble globulin; CIG; FN1	Human	HEK293
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. Fibronectin Protein, Human (HEK293, His) is the recombinant human-derived Fibronectin protein, expressed by HEK293 , with C-His labeled tag.

HY-P700991

	Fibronectin Protein, Human (314a.a, HEK293, His) FN; CIG; FN1; ED-B; FINC; FNZ; GFND; GFND2; LETS; MSF; SMDCF	Human	HEK293
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. Fibronectin Protein, Human (314a.a, HEK293, His) is the recombinant human-derived Fibronectin protein, expressed by HEK293 , with C-His labeled tag. The total length of Fibronectin Protein, Human (314a.a, HEK293, His) is 314 a.a., with molecular weight of 40-55 kDa.

HY-P700992

	Fibronectin Protein, Human (571a.a, HEK293, His) FN; CIG; FN1; ED-B; FINC; FNZ; GFND; GFND2; LETS; MSF; SMDCF	Human	HEK293
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. Fibronectin Protein, Human (571a.a, HEK293, His) is the recombinant human-derived Fibronectin protein, expressed by HEK293 , with C-His labeled tag. The total length of Fibronectin Protein, Human (571a.a, HEK293, His) is 571 a.a., with molecular weight of 70-80 kDa.

HY-P703663

	Fibronectin Protein, Human (91a.a, HEK293, His) FN; CIG; FN1; ED-B; FINC; FNZ; GFND; GFND2; LETS; MSF; SMDCF	Human	HEK293

HY-P70593G

	*GMP Fibronectin* Protein, Human** NovoNectin; Fibronectin; FN; Cold-insoluble globulin; CIG; FN; Fibronectin 1	Human	E. coli
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. GMP Fibronectin Protein, Human is a recombinant protein dimer complex containing human-derived Fibronectin protein, expressed by E. coli , with tag free. GMP Fibronectin Protein, Human, has molecular weight of ~60.0 kDa.

HY-P76935

	FNDC4 Protein, Human (HEK293, Fc) Fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1; FRCP1	Human	HEK293
	The FNDC4 protein is an anti-inflammatory factor in the intestine and colon that regulates macrophages by downregulating pro-inflammatory gene expression and affecting phagocytosis. It does this by modulating key pathways associated with macrophage activation, in part through STAT3 activation and signaling. FNDC4 Protein, Human (HEK293, Fc) is the recombinant human-derived FNDC4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FNDC4 Protein, Human (HEK293, Fc) is 123 a.a., with molecular weight of ~50-60 KDa.

HY-P70664

	Irisin Protein, Human/Mouse/Rat (HEK293, His) 4 Publications Verification Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FNDC5	Rat;Mouse;Human	HEK293
	Irisin is a hormone derived from the fibronectin type III domain-containing (FNDC5) gene that can promote energy expenditure via thermogenesis. Irisin Protein, Human/Mouse/Rat (HEK293, His) is a Irisin protein labeled with a His-flag.

HY-P703742

	Fibronectin (1266-1356) Protein, Human (HEK293, hFc)	Human	HEK293

HY-P70665

	Irisin Protein, Human/Mouse/Rat (HEK293, Fc) 1 Publications Verification Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FNDC5	Rat;Mouse;Human	HEK293
	Irisin is a hormone derived from the FNDC5 gene that promotes energy expenditure via thermogenesis. Irisin Protein, Human/Mouse/Rat (HEK293, Fc) is the recombinant human-derived Irisin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Irisin Protein, Human/Mouse/Rat (HEK293, Fc) is 112 a.a., with molecular weight of 42-60 kDa.

HY-P72534

	Irisin Protein, Human/Mouse/Rat (HEK293, N-His) 2 Publications Verification Fibronectin type III domain-containing protein 5; Irisin; FNDC5; FRCP2	Human;Rat;Mouse	HEK293
	Irisin is a hormone derived from the FNDC5 gene that promotes energy expenditure via thermogenesis. Irisin Protein, Human/Mouse/Rat (HEK293, N-His) is the recombinant human, rat, mouse-derived Irisin protein, expressed by HEK293 , with N-6*His labeled tag. The total length of Irisin Protein, Human/Mouse/Rat (HEK293, N-His) is 112 a.a., with molecular weight of 18-28 kDa.

HY-P703668

	Fibronectin/FN1 Protein, Human CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF; SMDCF	Human	E. coli

HY-P70925

	FLRT1 Protein, Human (HEK293, His) Leucine-Rich Repeat Transmembrane protein FLRT1; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane protein 1; FLRT1	Human	HEK293
	FLRT1 is a key player in FGF-mediated signaling, activating MAP kinase and enhancing neurite outgrowth through FGFR1-mediated signaling.It helps increase the number and length of neurites. FLRT1 Protein, Human (HEK293, His) is the recombinant human-derived FLRT1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70924

	FLRT3 Protein, Human (HEK293, His) Leucine-Rich Repeat Transmembrane protein FLRT3; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane protein 3; FLRT3; KIAA1469	Human	HEK293
	The FLRT3 protein exhibits multiple roles in cellular processes, affecting cell-cell adhesion, migration, and axonal guidance, with context-dependent attraction or repulsion.FLRT3 is critical for the spatial organization of brain neurons and also contributes to retinal blood vessel development.FLRT3 Protein, Human (HEK293, His) is the recombinant human-derived FLRT3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70201

	FLRT2 Protein, Human (HEK293, His) rHuLeucine-rich repeat transmembrane protein FLRT2/FLRT2, His; Leucine-Rich Repeat Transmembrane protein FLRT2; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane protein 2; FLRT2; KIAA0405	Human	HEK293
	FLRT2 protein is involved in cell-cell adhesion, migration, and axonal guidance through various interactions.It promotes adhesion by binding to ADGRL3 and potentially other sloth proteins.FLRT2 Protein, Human (HEK293, His) is the recombinant human-derived FLRT2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72533

	ITGA5 Protein, Human (HEK293, His) Integrin Alpha-5; Fibronectin Receptor Subunit Alpha; Integrin Alpha-F; VLA-5; CD49e; ITGA5; FNRA	Human	HEK293
	ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin, fibrinogen, PLA2G2A, fibrillin-1 (FBN1), IL1B, human metapneumovirus, and soluble CD40LG. ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites. ITGA5 Protein, Human (HEK293, His) is the recombinant human-derived ITGA5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ITGA5 Protein, Human (HEK293, His) is 954 a.a., with molecular weight of ~130 kDa.

HY-P704063

	Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, Human (HEK293, His, Avi) Vitronectin receptor; Fibronectin receptor subunit beta; Glycoprotein IIa (GPIIA)	Human	HEK293

HY-P70257

	Integrin beta-1/CD29 Protein, Human (HEK293, His) rHuIntegrin beta-1/ITGB1, His; Integrin Beta-1; Fibronectin Receptor Subunit Beta; VLA-4 Subunit Beta; CD29; ITGB1; FNRB; MDF2; MSK12	Human	HEK293
	Integrin beta-1/CD29 forms distinct heterodimers that act as multifunctional receptors for extracellular matrix proteins. It recognizes collagen, fibronectin, fibrinogen and laminin and plays a key role in cell functions such as migration, adhesion and angiogenesis. Integrin beta-1/CD29 Protein, Human (708a.a, HEK293, His) is the recombinant human-derived Integrin beta-1/CD29 protein, expressed by HEK293 , with C-6*His labeled tag.

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Fibronectin protein

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