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Results for "

GSPT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Apoptosis (6) Btk (1) c-Myc (2) Casein Kinase (1) E3 Ligase Ligand-Linker Conjugates (3) Epigenetic Reader Domain (1) IKZF Family (1) JAK (1) Ligands for E3 Ligase (3) Ligands for Target Protein for PROTAC (1) Molecular Glues (10) PROTAC Linkers (2) PROTACs (9) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156747

GSPT1 degrader-2	Others	Cancer
GSPT1 degrader-2 is a potent *GSPT1* degrader ^[1].

HY-162534

GSPT1 degrader-5	Molecular Glues	Cancer
GSPT1 degrader-5 (4) is a *GSPT1* molecule glue (DC₅₀ of 144 nM) ^[1].

HY-162535

GSPT1 degrader-6	Molecular Glues	Cancer
GSPT1 degrader-6 (8) is a *GSPT1* molecule glue (DC₅₀ of 13 nM) ^[1].

HY-162533

GSPT1 degrader-4	Molecular Glues	Cancer
GSPT1 degrader-4 (3) is a *GSPT1* molecule glue (DC₅₀ of 25.4 nM), with an IC₅₀ of 39 nM for CAL51 proliferation ^[1].

HY-155552

GSPT1 degrader-1	Apoptosis	Cancer
GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis ^[1].

HY-RS05868

GSPT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GSPT1 Human Pre-designed siRNA Set A contains three designed siRNAs for GSPT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GSPT1 Human Pre-designed siRNA Set A GSPT1 Human Pre-designed siRNA Set A

HY-157426

GSPT1 degrader-3	Epigenetic Reader Domain PROTACs	Cancer
GSPT1 degrader-3 (Pro-2) is a CRBN-based PROTAC degrader for BRD, with a DC₅₀ of 21.1 nM (4h) ^[1].

HY-159610

*PROTAC GSPT1* degrader-2**	Molecular Glues	Cancer
PROTAC GSPT1 degrader-2 (compound A) is a *GSPT1* molecule glue with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC₅₀ of 10 nM ^[1].

HY-159609

*PROTAC GSPT1* degrader-1**	PROTACs	Cancer
PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). PROTAC GSPT1 degrader-1 inhibits the cell viability of HL-60 with an IC₅₀ of 9.2 nM. (Pink: ligand for target protein (HY-W599025); Black: linker (HY-159619); Blue: ligand for E3 ligase (HY-W087383)) ^[1]

HY-161696

AN5777	Apoptosis	Cancer
AN5777 is a *GSPT1* degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity ^[1].

HY-153803

GBD-9	PROTACs Molecular Glues Btk	Cancer
GBD-9 is a double-mechanism degrader that efficiently degrades BTK and *GSPT1* by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth ^[1].

HY-150616

SJPYT-195	Molecular Glues	Cancer
SJPYT-195 is a cytotoxic *GSPT1* degrader and can be used for PROTAC synthesis ^[1].

HY-132199

SJ6986	Others	Cancer
SJ6986 is a potent, selective and orally active *GSPT1/2* degrader, with a DC₅₀ of 2.1 nM (D_max 99%) for GSPT1 ^[1].

HY-130800

Eragidomide 1 Publications Verification CC-90009	Ligands for E3 Ligase Molecular Glues Apoptosis	Inflammation/Immunology Cancer
Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4 ^CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation ^[1] .

HY-147158

ZXH-1-161	Molecular Glues Ligands for E3 Ligase	Cancer
ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC₅₀ value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma ^[1].

HY-136688

MI-389	PROTACs	Cancer
MI-389 is a PROTAC translation termination factor *GSPT1* degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4 ^CRBN E3 ligase ^[1].

HY-101488

CC-885 10+ Cited Publications	Molecular Glues Ligands for E3 Ligase	Cancer
CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of *GSPT1*, inhibiting protein translation.

HY-150259

MDEG-541	PROTACs c-Myc	Cancer
MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein ^[1].

HY-161101

MG degrader 1	PROTACs IKZF Family	Cancer
MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, *GSPT1, and GSPT2* with an EC₅₀ value of 1.385 nM in MM.1S cells ^[1].

HY-159622

Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl	PROTAC Linkers	Cancer
Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl is a PROTAC Linker. Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used in synthesis PROTAC GSPT1 degrader-2 (HY-159610) ^[1].

HY-159619

Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl	PROTAC Linkers	Cancer
Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl is a PROTAC Linker. Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl can be used in the synthesis of PROTAC GSPT1 degrader-1 (HY-159609) ^[1].

HY-130122

MG-277	Molecular Glues PROTACs Apoptosis	Cancer
MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, *GSPT1, with a DC₅₀* of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC₅₀s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity ^[1].

HY-159623

Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl is an E3 Ligase Ligand-Linker Conjugate. Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used to synthesize PROTAC GSPT1 degrader-2 (HY-159610) ^[1].

HY-143435

AG6033	Apoptosis	Cancer
AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect ^[1].

HY-159620

Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl is an E3 Ligase Ligand-Linker Conjugate. Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl can be used to synthesize PROTAC GSPT1 degrader-1 (HY-159609) ^[1].

HY-W599025

5-Br-4-Cl-Pyrrolo-pyroxypyridine	Ligands for Target Protein for PROTAC	Cancer
5-Br-4-Cl-Pyrrolo-pyroxypyridine is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). 5-Br-4-Cl-Pyrrolo-pyroxypyridine can be used for synthesis PROTAC GSPT1 degrader-1 (HY-159609) ^[1].

HY-164202

ORM-5029	Antibody-Drug Conjugates (ADCs)	Cancer
ORM-5029 is a first-in-class human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate (ADC) comprised of SMol006, a highly potent GSPT1 degrader, conjugated to Pertuzumab (HY-P9912). ORM-5029 can be used for study of cancer ^[1].

HY-151902

SJ988497	PROTACs JAK	Cancer
SJ988497 is a PROTAC JAK2 degrader. SJ988497 potently inhibits CRLF2-rearranged (CRLF2r) cell proliferation and degrades the CRBN neosubstrate GSPT1. SJ988497 consists of a Ruxolitinib (HY-50856) derivative, linker, and CRBN ligand Pomalidomide. SJ988497 can be used in the research of acute lymphoblastic leukemia (ALL) ^[1].

HY-148837

c-Myc inhibitor 7	c-Myc Casein Kinase	Infection Cardiovascular Disease Cancer
c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades c-MYC, *CK1α, GSPT1* and *IKZF1/2/3* proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection ^[1].

HY-163938A

PROTAC erf3a Degrader-2	PROTACs	Cancer
PROTAC erf3a Degrader-2 (Compound C59) is an orally active PROTAC erf3a Degrader. PROTAC erf3a Degrader-2 inhibits protein expression of SRD5A3 and GSPT1(eRF3a). PROTAC erf3a Degrader-2 inhibits cancer cell proliferation (eg: 22Rv1). PROTAC erf3a Degrader-2 can be used for research of prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer. (Red: erf3a ligand (HY-13778); Black: linker (HY-163960); Blue: E3 ligase ligand (HY-W763812)) ^[1].

HY-153356

MRT-2359	Apoptosis	Cancer
MRT-2359 is a potent, orally active and selective *GSPT1* depressant (IC₅₀: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research ^[1] .

HY-145448

MC-VC-PABC-amide-PEG1-CH2-CC-885	E3 Ligase Ligand-Linker Conjugates	Cancer
MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound III) is a neoDegrader, a conjugate of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs). MC-VC-PABC-amide-PEG1-CH2-CC-885 can also be conjugated to Belantamab (HY-P9980), Daratumumab (HY-P9915), huMy9-6 IgG1, Indatuximab (HY-P990607), Isatuximab (HY-P9976), lintuzumab IgG1, Pertuzumab (HY-P9912), OR000213, Rituximab (HY-P9913), Sacituzumab (HY-P99045), Trastuzumab (HY-P9907)and U3-1784 (HY-P990672) to form conjugates ^[1] .

Cat. No.	Compare	Product Name	Species	Source

HY-P703141

	GSPT1 Protein, Human (Sf9, Biotinylated, Avi) ERF3A	Human	Sf9 insect cells
	GSPT1 Protein, Human (Sf9, Biotinylated, Avi) is the recombinant human-derived GSPT1, expressed by Sf9 insect cells , with Avi labeled tag. The total length of GSPT1 Protein, Human (Sf9, Biotinylated, Avi) is 636 a.a.,

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GSPT1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GSPT1 Human Pre-designed siRNA Set A contains three designed siRNAs for GSPT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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