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Gene Delivery Vectors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Biochemical Assay Reagents (2) IFNAR (1) Interleukin Related (1) Liposome (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Neurological Disease (1)
Oligonucleotides:	Cationic Lipids (2) Cholesterol (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Oligonucleotides

Targets Recommended: CGRP Receptor LAG-3 Dan family MALT1 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W250110B

Polyethylenimine (linear, average Mn 2100, PDI<1.3) PEI (linear, average Mn 2100, PDI<1.3)	Biochemical Assay Reagents	Cancer
Polyethylenimine (linear, average Mn 2100, PDI<1.3), a linear cationic polymer, is a versatile non-viral gene delivery vector, especially for oligonucleotide delivery. Polyethylenimine (linear, average Mn 2100, PDI<1.3) condenses DNA into positively charged particles that bind to anionic cell surfaces. Polyethylenimine (PEI) can be used in detergents, adhesives, water treatment agents and cosmetics .

HY-147087

YSK 05	Liposome	Cancer
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

HY-N3540

Caraphenol A	Others	Inflammation/Immunology
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-W127378

DOTAP methylsulfate 5+ Cited Publications 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate	Liposome	Others
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Amyloid-β Liposome IFNAR Interleukin Related	Neurological Disease Inflammation/Immunology
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-126721

Tetralysine	Biochemical Assay Reagents	Others
Tetralysine is a cationic moietie that may be used in the construction of gene delivery vectors and DNA nanoparticles .

HY-P10514

Transportan 10	Small Interfering RNA (siRNA)	Others
Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research .

Cat. No.	Product Name	Type

HY-W250110B

Polyethylenimine (linear, average Mn 2100, PDI<1.3) PEI (linear, average Mn 2100, PDI<1.3)	Drug Delivery
Polyethylenimine (linear, average Mn 2100, PDI<1.3), a linear cationic polymer, is a versatile non-viral gene delivery vector, especially for oligonucleotide delivery. Polyethylenimine (linear, average Mn 2100, PDI<1.3) condenses DNA into positively charged particles that bind to anionic cell surfaces. Polyethylenimine (PEI) can be used in detergents, adhesives, water treatment agents and cosmetics .

Polyethylenimine (linear, average Mn 2100, PDI<1.3)

PEI (linear, average Mn 2100, PDI<1.3)

Drug Delivery

Polyethylenimine (linear, average Mn 2100, PDI<1.3), a linear cationic polymer, is a versatile non-viral gene delivery vector, especially for oligonucleotide delivery. Polyethylenimine (linear, average Mn 2100, PDI<1.3) condenses DNA into positively charged particles that bind to anionic cell surfaces. Polyethylenimine (PEI) can be used in detergents, adhesives, water treatment agents and cosmetics .

HY-147087

YSK 05	Drug Delivery
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

HY-W127378

DOTAP methylsulfate 5+ Cited Publications 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate	Drug Delivery
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].

DOTAP methylsulfate

5+ Cited Publications

1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate

Drug Delivery

DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Drug Delivery
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

DC-Chol hydrochloride

DC-Cholesterol hydrochloride

Drug Delivery

DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

Cat. No.	Product Name	Target	Research Area

HY-P5284

RALA peptide	Peptides	Others
RALA peptide is a cell-penetrating peptide. RALA peptide can be as non-viral gene delivery vectors .

HY-126721

Tetralysine	Biochemical Assay Reagents	Others
Tetralysine is a cationic moietie that may be used in the construction of gene delivery vectors and DNA nanoparticles .

HY-P10514

Transportan 10	Small Interfering RNA (siRNA)	Others
Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

Cat. No.	Product Name		Classification

HY-147087

YSK 05		Cationic Lipids
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

HY-W127378

DOTAP methylsulfate 5+ Cited Publications 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate		Cationic Lipids
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design[1][2].

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride		Cholesterol
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

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Gene Delivery Vectors

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Oligonucleotides

Natural
Products