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32

Inhibitors & Agonists

1

Fluorescent Dye

2

Inhibitory Antibodies

1

Natural
Products

5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0161A
    Duloxetine hydrochloride
    4 Publications Verification

    (S)-Duloxetine hydrochloride; LY-248686 hydrochloride

    		 Serotonin Transporter Neurological Disease Cancer
    Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .
    Duloxetine hydrochloride
  • HY-152166
    NaV1.2/1.6 channel blocker-1

    		Sodium Channel Neurological Disease
    NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy .
    NaV1.2/1.6 channel blocker-1
  • HY-118901
    Opipramol

    Ensidon; G-33040

    		 Sigma Receptor Neurological Disease
    Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
    Opipramol
  • HY-122487
    Troriluzole

    BHV-4157

    		 Others Neurological Disease Cancer
    Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .
    Troriluzole
  • HY-U00073
    Benin

    Butocin; Butocine

    		 Others Cancer
    Benin is a potent cytostatic agent that can be used for the treatment of generalized carcinoma of the breast.
    Benin
  • HY-19872
    AZD-6280

    		GABA Receptor Neurological Disease
    AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder.
    AZD-6280
  • HY-B0161
    Duloxetine

    LY248686

    		 Serotonin Transporter Neurological Disease Cancer
    Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .
    Duloxetine
  • HY-B0161AS
    Duloxetine D3 hydrochloride

    (S)-Duloxetine-d3 (hydrochloride); LY248686-d3 (hydrochloride)

    		 Serotonin Transporter Neurological Disease
    Duloxetine-d3 (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].
    Duloxetine D3 hydrochloride
  • HY-110029
    Paroxetine maleate

    BRL29060 maleate

    		 Serotonin Transporter Neurological Disease
    Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research .
    Paroxetine maleate
  • HY-118901R
    Opipramol (Standard)

    		Sigma Receptor Neurological Disease
    Opipramol (Standard) is the analytical standard of Opipramol. This product is intended for research and analytical applications. Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
    Opipramol (Standard)
  • HY-B1115S
    Buspirone-d8 hydrochloride

    		Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Buspirone-d8 (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD).
    Buspirone-d8 hydrochloride
  • HY-W012734
    L-Pipecolic acid
    1 Publications Verification

    H-HoPro-OH

    		 Endogenous Metabolite Metabolic Disease
    L-Pipecolic acid (H-HoPro-OH) is a breakdown product of lysine, accumulates in body fluids of infants with generalized genetic peroxisomal disorders, such as Zellweger syndrome, neonatal adrenoleukodystrophy.
    L-Pipecolic acid
  • HY-112723
    Apinocaltamide

    ACT-709478

    		 Calcium Channel Neurological Disease
    Apinocaltamide (ACT-709478) is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies .
    Apinocaltamide
  • HY-D0080
    Laurdan
    5 Publications Verification

    		 Fluorescent Dye Others
    Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of Laurdan can be used to identify phospholipid phase.
    Laurdan
  • HY-B1115A
    Buspirone
    1 Publications Verification

    		 5-HT Receptor Dopamine Receptor Reactive Oxygen Species Neurological Disease Cancer
    Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research .
    Buspirone
  • HY-B0161S
    Duloxetine-d7

    		Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Duloxetine-d7 ((S)-Duloxetine-d7) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].
    Duloxetine-d7
  • HY-B0161AR
    Duloxetine hydrochloride (Standard)

    (S)-Duloxetine hydrochloride (Standard); LY-248686 hydrochloride (Standard)

    		 Serotonin Transporter Neurological Disease Cancer
    Duloxetine (hydrochloride) (Standard) is the analytical standard of Duloxetine (hydrochloride). This product is intended for research and analytical applications. Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .
    Duloxetine hydrochloride (Standard)
  • HY-101708
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

    		Others Neurological Disease
    N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(1R)-1-(4-hydroxyphenyl)ethyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
  • HY-14948
    Carisbamate

    RWJ-333369

    		 Others Neurological Disease
    Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy .
    Carisbamate
  • HY-P99659
    Imsidolimab

    ANB 019

    		 Interleukin Related Inflammation/Immunology
    Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti-IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases .
    Imsidolimab
  • HY-B1115AR
    Buspirone (Standard)

    		5-HT Receptor Dopamine Receptor Reactive Oxygen Species Neurological Disease Cancer
    Buspirone (Standard) is the analytical standard of Buspirone. This product is intended for research and analytical applications. Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research .
    Buspirone (Standard)
  • HY-159819
    Vormatrigine

    		Sodium Channel Neurological Disease
    Vormatrigine is an orally active sodium channel inhibitor with anti-epileptic activity. Vormatrigine has a specific inhibitory effect on overactive NaV channels in vitro and has a good inhibitory effect in the maximal electroconvulsive seizure (MES) model. Vormatrigine can be used to study human focal and generalized epilepsy .
    Vormatrigine
  • HY-B0161AS1
    Duloxetine-d7 hydrochloride

    (S)-Duloxetine-d7 hydrochloride; LY248686-d7 hydrochloride

    		 Isotope-Labeled Compounds Serotonin Transporter Neurological Disease Cancer
    Duloxetine-d7 hydrochloride ((S)-Duloxetine-d7 hydrochloride) is the deuterium labeled Duloxetine hydrochloride (HY-B0161A). Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .
    Duloxetine-d7 hydrochloride
  • HY-19686
    Ipsapirone

    TVX Q 7821 free base

    		 5-HT Receptor Neurological Disease
    Ipsapirone (TVX Q 7821) is an anxiolytic compound and a 5-HT1A receptor partial agonist. Ipsapirone (TVX Q 7821) also exhibits 5-HT1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function .
    Ipsapirone
  • HY-19686A
    Ipsapirone hydrochloride

    TVX Q 7821

    		 5-HT Receptor Neurological Disease
    Ipsapirone hydrochloride (TVX Q 7821) is an anxiolytic compound and a 5-HT1A receptor partial agonist. Ipsapirone hydrochloride (TVX Q 7821) also exhibits 5-HT1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function .
    Ipsapirone hydrochloride
  • HY-B1496
    Tranylcypromine hemisulfate
    4 Publications Verification

    SKF 385 hemisulfate

    		 Monoamine Oxidase Histone Demethylase Neurological Disease Cancer
    Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .
    Tranylcypromine hemisulfate
  • HY-17447SA
    Tranylcypromine-d5 hydrochloride

    SKF 385-d5 hydrochloride

    		 Monoamine Oxidase Histone Demethylase Neurological Disease
    Tranylcypromine-d5 (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].
    Tranylcypromine-d5 hydrochloride
  • HY-P99248
    Risankizumab

    Risankizumab rzaa; BI 655066

    		 Interleukin Related Inflammation/Immunology
    Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis .
    Risankizumab
  • HY-B1496R
    Tranylcypromine hemisulfate (Standard)

    		Monoamine Oxidase Histone Demethylase Neurological Disease
    Tranylcypromine (hemisulfate) (Standard) is the analytical standard of Tranylcypromine (hemisulfate). This product is intended for research and analytical applications. Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .
    Tranylcypromine hemisulfate (Standard)
  • HY-120045A
    DuP 747 hydrochloride

    		Opioid Receptor Neurological Disease
    DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration .
    DuP 747 hydrochloride
  • HY-W052508
    Norquetiapine

    N-Desalkylquetiapine

    		 5-HT Receptor Neurological Disease
    Norquetiapine is an antidepressant and neuroprotective agent and is the active metabolic component of Quetiapine (HY-14544). Norquetiapine is also a partial 5-HT1A receptor agonist, and a presynaptic α2, 5-HT2C and 5-HT7 b> Receptor antagonist. Norquetiapine can also selectively inhibit norepinephrine transporter (NET), inhibit norepinephrine reuptake, and has potential inhibitory effects on bipolar depression, major depressive disorder, and generalized anxiety disorder. Norquetiapine demonstrated in vivo activity in forced swimming in mice and learned helplessness tests in rats .
    Norquetiapine
  • HY-125372
    2-Amino benzamidoxime

    ABAO

    		 Biochemical Assay Reagents Others
    2-Amino benzamidoxime (ABAO compound 6) can react quickly with aldehydes to form stable 1, 2-dihydroquinazoline 3-oxides in aqueous solutions. The 2-Amino benzamidoxime reaction process consists of the formation of a Schiff base as a rate-determining step, followed by rapid intramolecular cyclization. The reaction rate is dependent on pH, indicating that protonated benzamidoxime is involved in the formation of Schiff bases as an internal generalized acid. Substituents on the aromatic ring can increase the alkalinity of the aromatic amine, thus speeding up the reaction. The reactive properties of 2-Amino benzamidoxime make it a potential platform for the development of new bioconjugated strategies, fluorescent probes, and post-translational diversification of genetic coding libraries .
    2-Amino benzamidoxime

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