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HK-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (6) Arginase (1) Caspase (1) Dopamine Receptor (3) EGFR (1) Endogenous Metabolite (2) Fluorescent Dye (1) GSK-3 (1) Hexokinase (2) Histone Demethylase (1) Interleukin Related (1) MDM-2/p53 (1) NF-κB (1) NOD-like Receptor (NLR) (1) P-glycoprotein (1) PI3K (1) PPAR (2) RIP kinase (1) Small Interfering RNA (siRNA) (1) STAT (1) TGF-β Receptor (2) Thrombin (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) TRP Channel (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (4) Infection (2) Inflammation/Immunology (5) Metabolic Disease (9)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155008

*PROTAC HK2* Degrader-1** 1 Publications Verification	Hexokinase	Cancer
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .

HY-130437

p-nitro-Pifithrin-α	MDM-2/p53 TGF-β Receptor Caspase	Infection Metabolic Disease
p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease ^[2] .

HY-134929

Hexokinase 2 inhibitor 1	Hexokinase	Infection
Hexokinase 2 inhibitor 1 (Compound 2a) is a hexokinase 2 (HK2) inhibitor with anti-tumor activity and can be used in cancer research .

HY-126710

OU749	Others	Cancer
OU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a K_i value of 17.6 µM. OU749 shows cytotoxicity .

HY-RS06193

HK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HK2 Human Pre-designed siRNA Set A contains three designed siRNAs for HK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HK2 Human Pre-designed siRNA Set A HK2 Human Pre-designed siRNA Set A

HY-N1960

Ophiopogonin A	Apoptosis	Inflammation/Immunology
Ophiopogonin A is a natural steroid that can be found in Ophiopogon japonicus. Ophiopogonin A dose-dependently inhibits hemorrhagic shock (HS)-induced tissue damage and apoptosis. ophiopogonin A dose-dependently promotes the phosphorylation of ERK in HS kidney tissues and hypoxia-treated HK-2 cells .

HY-156276

SP4e	PPAR	Metabolic Disease
SP4e is an activator of PPAR-γ, with the EC₅₀ of 739 nM in HK-2 cells. SP4e reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .

HY-156277

SP4f	PPAR	Metabolic Disease
SP4f is an activator ofPPAR-γ, with the EC₅₀ of 826 nM in HK-2 cells. SP4f reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .

HY-156368

RIPK3-IN-4	RIP kinase	Inflammation/Immunology
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin (HY-17394)- and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury .

HY-N10760

2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid	Others	Metabolic Disease
2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid (compound 3), a triterpenoid, significantly decreases the level of fibronectin in High-Glucose and TGF-b1 induced HK-2 cells with 27.66 % inhibition rate at 10 μM .

HY-123409

Nicousamide	TGF-β Receptor	Metabolic Disease
Nicousamide is a potent inhibitor of TGF-β RII phosphorylation. Nicousamide can be used to study renal fibrosis in animal models of diabetic nephropathy .

HY-N0401B

(E)-Ligustilide	Others	Metabolic Disease
(E)-Ligustilide is isolated from Angelica?sinensis and has nephroprotective?effects .

HY-155751

HMGB1-IN-1	Interleukin Related TNF Receptor NOD-like Receptor (NLR)	Inflammation/Immunology
HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC₅₀ value of 15.9 ± 0.6 μM. HMGB1-IN-1 inhibit the HMGB1/NF-κB/NLRP3 pathway. HMGB1-IN-1 shows good anti-inflammatory activity and good anti-sepsis effects in kidney injury .

HY-B1352

L-Ornithine 4 Publications Verification (S)-2,5-Diaminopentanoic acid	Arginase Endogenous Metabolite	Metabolic Disease
L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective ^[2].

HY-W017018

L-Ornithine hydrochloride 4 Publications Verification	Endogenous Metabolite	Metabolic Disease
L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective ^[2].

HY-122615A

SPOP-IN-6b hydrochloride	Others	Cancer
SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM .

HY-122615B

SPOP-IN-6b dihydrochloride 1 Publications Verification	Others	Cancer
SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM .

HY-146560

Xanthine oxidase-IN-6	Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity .

HY-110021

Fenoldopam hydrochloride SKF 82526 hydrochloride	Dopamine Receptor Histone Demethylase Apoptosis	Cardiovascular Disease Cancer
Fenoldopam (SKF 82526) hydrochloride is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis ^[2] .

HY-151544

PNE-Lyso	Fluorescent Dye	Others
PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process .

HY-149053

OY-101	P-glycoprotein	Cancer
OY-101 is an orally active, potent and specific P-glycoprotein (P-gp) inhibitor. OY-101 can sensitize drug-resistant tumors and effectively reverse tumor multidrug resistance. OY-101 is improvements in water-solubility, cytotoxicity, and reversal activity compared to Tetrandrine (HY-13764) .

HY-163748

GSK-3β inhibitor 17	GSK-3	Inflammation/Immunology
GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury .

HY-161852

PI3K-IN-55	PI3K Apoptosis	Cancer
PI3K-IN-55 (Compound 6a) is a potent inhibitor for PI3K. PI3K-IN-55 affects PI3K/Akt/p53 signaling pathway, inhibits the proliferation of cancer cells A549, Hela, HepG2, MCF-7 and HT-29, with IC₅₀s of 1.03-6.78 μM. PI3K-IN-55 induces apoptosis in cell MCF-7 .

HY-162584

TRPC4/5-IN-2	TRP Channel	Others
TRPC4/5-IN-2 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC₅₀ value of 81 nM. TRPC4/5-IN-2 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD) .

HY-P5314

OK2	EGFR STAT	Others
OK2, a specific inhibitor of the *CCN2/EGFR* interaction, efficiently blocks *CCN2/EGFR* interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research .

HY-P2813

Hirudin	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

HY-B0735A

Fenoldopam mesylate 4 Publications Verification Fenoldopam methanesulfonate; SKF-82526 mesylate	Dopamine Receptor Apoptosis	Cardiovascular Disease Cancer
Fenoldopam mesylate (SKF-82526) is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis ^[2] .

HY-B0735AR

Fenoldopam mesylate (Standard)	Dopamine Receptor Apoptosis	Cardiovascular Disease Cancer
Fenoldopam (mesylate) (Standard) is the analytical standard of Fenoldopam (mesylate). This product is intended for research and analytical applications. Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis ^[2] .

Cat. No.	Product Name	Type

HY-151544

PNE-Lyso	Fluorescent Dyes/Probes
PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process .

Cat. No.	Product Name	Target	Research Area

HY-P2618

Pro-Phe-Arg-AMC acetate	Peptides	Others
Pro-Phe-Arg-AMC acetate is a peptide that can be used as the substrate of human glandular kallikrein 2 (hK2) .

HY-P5314

OK2	EGFR STAT	Others
OK2, a specific inhibitor of the *CCN2/EGFR* interaction, efficiently blocks *CCN2/EGFR* interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research .

HY-P2813

Hirudin	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

L-Ornithine 4 Publications Verification (S)-2,5-Diaminopentanoic acid	Structural Classification Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Arginase Endogenous Metabolite
L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective ^[2].

L-Ornithine hydrochloride 4 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective ^[2].

Ophiopogonin A	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Source classification Plants Steroids	Apoptosis
Ophiopogonin A is a natural steroid that can be found in Ophiopogon japonicus. Ophiopogonin A dose-dependently inhibits hemorrhagic shock (HS)-induced tissue damage and apoptosis. ophiopogonin A dose-dependently promotes the phosphorylation of ERK in HS kidney tissues and hypoxia-treated HK-2 cells .

2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid	Triterpenes Structural Classification Juglandaceae Terpenoids Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants	Others
2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid (compound 3), a triterpenoid, significantly decreases the level of fibronectin in High-Glucose and TGF-b1 induced HK-2 cells with 27.66 % inhibition rate at 10 μM .

(E)-Ligustilide	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC.	Others
(E)-Ligustilide is isolated from Angelica?sinensis and has nephroprotective?effects .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82984

	Kallikrein 2 Antibody (YA2729) HK2; hGK-1; KLK2A2	WB, ICC/IF	Human, Mouse, Rat
	Kallikrein 2 Antibody (YA2729) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2729), targeting Kallikrein 2, with a predicted molecular weight of 29 kDa (observed band size: 33 kDa). Kallikrein 2 Antibody (YA2729) can be used for WB, ICC/IF experiment in human, mouse, rat background.

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HK2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
HK2 Human Pre-designed siRNA Set A contains three designed siRNAs for HK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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