Heparan Sulfate

By Targets:	Endogenous Metabolite (1) FGFR (3) HSV (2) Integrin (1) Notch (1) Transferrin Receptor (1) VEGFR (2) Wnt (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (7) Infection (2) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101916

**Heparan Sulfate** Maximum Cited Publications 13 Publications Verification	FGFR Wnt Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

HY-135197

L-Iduronic acid sodium salt	Others	Others
L-Iduronic acid sodium salt is an important monosaccharide component of glycosaminoglycans (GAGs) such as Heparin, Heparan sulfate and Dermatan sulfate .

HY-122704A

Surfen dihydrochloride 1 Publications Verification Aminoquinuride dihydrochloride	FGFR HSV VEGFR	Infection
Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .

HY-P3160

Fibronectin 2 Publications Verification	Integrin	Cardiovascular Disease Inflammation/Immunology
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

HY-100898

OGT 2115 3 Publications Verification	Others	Cancer
OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC₅₀ of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC₅₀ of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity .

HY-P99797

Pabinafusp alfa JR-141	Transferrin Receptor	Neurological Disease
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .

HY-E70172

Heparan Sulfate 3-O-Sulfotransferase 4 EC:2.8.2.23; HS3ST4; 3-OST-4	Notch	Neurological Disease
Heparan Sulfate 3-O-Sulfotransferase 4 is a sulfotransferase. Heparan Sulfate 3-O-Sulfotransferase 4 regulates Notch signaling .

HY-163388

CHI3L1-IN-2	Others	Others
CHI3L1-IN-2 (Compound 36) is a CHI3L1(YKL-40) inhibitor. CHI3L1-IN-2 inhibits the interaction between CHI3L1 and heparan sulfate (CHI3L1:HSIII), with an IC₅₀ of 26 nM .

HY-137259

Iduronate 2-sulfate IdOA(2S); 2-O-Sulfated iduronic acid	Others	Metabolic Disease
Iduronate 2-sulfate (IdOA(2S)) is critically important for the anticoagulant activity. Iduronate 2-sulfate (IdOA(2S)) residue is commonly found in heparan sulfate and heparin .

HY-122704

Surfen Aminoquinuride	FGFR HSV VEGFR	Infection
Surfen is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .

Cat. No.	Product Name	Type

HY-P3160

Fibronectin 2 Publications Verification	Native Proteins
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

HY-E70173

Heparan Sulfate 6-O-Sulfotransferase 1 EC:2.8.2.-; HS6ST1	Enzyme Substrates
Heparan Sulfate 6-O-Sulfotransferase 1 is a sulfotransferase. Heparan Sulfate 6-O-Sulfotransferase 1 is important in heparan sulfate biosynthesis .

HY-E70174

Heparan Sulfate 6-O-Sulfotransferase 3 EC:2.8.2.-; HS6ST3	Enzyme Substrates
Heparan Sulfate 6-O-Sulfotransferase 3 is a sulfotransferase. Heparan Sulfate 6-O-Sulfotransferase 3 is important in heparan sulfate biosynthesis .

HY-E70171

Heparan Sulfate 3-O-Sulfotransferase 1 EC:2.8.2.23; HS3ST1	Enzyme Substrates
Heparan Sulfate 3-O-Sulfotransferase 1 is a sulfotransferase. Heparan Sulfate 3-O-Sulfotransferase controls cellular production of the anticoagulant heparan sulfate related structure .

HY-E70175

Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3 EC:2.8.2.30; HS3ST3B1; 3OST3B1	Enzyme Substrates
Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3 is a sulfotransferase. Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3 is important in heparan sulfate biosynthesis .

HY-E70172

Heparan Sulfate 3-O-Sulfotransferase 4 EC:2.8.2.23; HS3ST4; 3-OST-4	Enzyme Substrates
Heparan Sulfate 3-O-Sulfotransferase 4 is a sulfotransferase. Heparan Sulfate 3-O-Sulfotransferase 4 regulates Notch signaling .

HY-E70170

Heparan Sulfate 2-O-Sulfotransferase 1 EC:2.8.2.-; HS2ST1	Enzyme Substrates
Heparan Sulfate 2-O-Sulfotransferase 1 is a sulfotransferase and influences dermatan sulfate biosynthesis .

HY-E70176

N-Deacetylase/N-Sulfotransferase 1 EC:2.8.2.8; NDST1	Enzyme Substrates
N-Deacetylase/N-Sulfotransferase 1 is a sulfotransferase. N-Deacetylase/N-Sulfotransferase 1 modifies heparan sulfate-dependent growth factor and morphogen signalling .

HY-E70177

N-Deacetylase/N-Sulfotransferase 2 EC:2.8.2.8; NDST2; N-HSST 2	Enzyme Substrates
N-Deacetylase/N-Sulfotransferase 2 is a sulfotransferase. N-Deacetylase/N-Sulfotransferase 2 synthesizes serglycin-bound heparin chains in mast cells .

Cat. No.	Product Name	Target	Research Area

HY-P99797

Pabinafusp alfa JR-141	Transferrin Receptor	Neurological Disease
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .

HY-P99694

Lepunafusp alfa JR-171	Inhibitory Antibodies	Neurological Disease
Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase). Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS). Lepunafusp alfa can be used for research of mucopolysaccharidosis type I .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101916

**Heparan Sulfate** 10+ Cited Publications	Structural Classification Polysaccharides Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	FGFR Wnt Endogenous Metabolite
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

HY-P3160

Fibronectin 2 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Integrin
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

Species:	Human (4) Mouse (1) Cynomolgus (1)
Tag:	His (5) Avi (1) Fc (1)
Source:	HEK293 (5) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P79181

	Heparan Sulfate-6-O-Sulfotransferase-3 Protein, Mouse (HEK293, His) Heparan-Sulfate 6-O-sulfotransferase 3	Mouse	HEK293
	Heparan Sulfate-6-O-Sulfotransferase-3 (HS6ST3) is an enzyme involved in modifying heparan sulfate proteoglycan biosynthesis. It is predicted to be a membrane-bound integral component. HS6ST3 shows specific expression in the adult cortex (RPKM 1.3) and frontal lobe (RPKM 0.8), implying its potential role in determining the sulfation patterns of heparan sulfate in these contexts. Heparan Sulfate-6-O-Sulfotransferase-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Heparan Sulfate-6-O-Sulfotransferase-3 protein, expressed by HEK293 , with N-His labeled tag.

HY-P70995

	Syndecan-2 Protein, Human (HEK293, His) Syndecan-2; SYND2; Fibroglycan; Heparan Sulfate Proteoglycan Core Protein; HSPG; CD362; SDC2; HSPG1	Human	HEK293
	Syndecan-2 Protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Syndecan-2 functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-2 is necessary for tumor angiogenesis that facilitates tumor growth and metastasis. Syndecan-2 Protein, Human (HEK293, His) is the recombinant human-derived Syndecan-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Syndecan-2 Protein, Human (HEK293, His) is 126 a.a., with molecular weight of 25-40 kDa.

HY-P70507

	CD44 Protein, Human (HEK293, His) CD44 Antigen; CDw44; Epican; Extracellular Matrix Receptor III; ECMR-III; GP90 Lymphocyte Homing/Adhesion Receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate Receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR	Human	HEK293
	CD44 Protein is a type of cell surface receptor protein. CD44 Protein mediates various signaling pathways, including protein kinases, changes in the cytoskeleton, intracellular pathways, proteases, and transcription factors, which promote cancer cell division, proliferation, invasion, angiogenesis, and metabolic changes. The expression level of CD44 Protein is positively correlated with the malignancy and invasiveness of glioblastoma. CD44 Protein, Human (HEK293, His) is a recombinant CD44 protein tagged with a C-6*His label, expressed by HEK293. CD44 Protein, Human (HEK293, His) consists of 200 amino acids and has a molecular weight of 38-50 kDa.

HY-P700402

	CD44 Protein, Human (Biotinylated, HEK293) CD44 Antigen; CDw44; Epican; Extracellular Matrix Receptor III; ECMR-III; GP90 Lymphocyte Homing/Adhesion Receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate Receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR	Human	HEK293
	CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (Biotinylated, HEK293) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of CD44 Protein, Human (Biotinylated, HEK293) is 200 a.a., with molecular weight of 51 kDa.

HY-P76974

	HS3ST1 Protein, Human (sf9, His) Heparan Sulfate glucosamine 3-O-sulfotransferase 1; 3-OST-1; 3OST; 3OST1	Human	Sf9 insect cells
	The HS3ST1 protein utilizes PAPS to crucially catalyze the transfer of sulfate to position 3 of the glucosamine residue in heparan sulfate (HS), representing the rate-limiting step in HS biosynthesis. This activity is essential for the formation of the anticoagulant heparan sulfate and completion of the antithrombin pentasaccharide binding site. HS3ST1 Protein, Human (sf9, His) is the recombinant human-derived HS3ST1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of HS3ST1 Protein, Human (sf9, His) is 287 a.a., with molecular weight of ~36 KDa.

HY-P700439

	CD44 Protein, Macaca fascicularis (HEK293, His) CD44 Antigen; CDw44; Epican; Extracellular Matrix Receptor III; ECMR-III; GP90 Lymphocyte Homing/Adhesion Receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate Receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR	Cynomolgus	HEK293
	The CD44 protein is characterized by a lack of conserved residues critical for annotation of propagation signatures. This defective residue in CD44 prevents the propagation of specific functional features associated with this protein. CD44 Protein, Macaca fascicularis (HEK293, His) is the recombinant cynomolgus-derived CD44 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CD44 Protein, Macaca fascicularis (HEK293, His) is 630 a.a., with molecular weight of 71.6 kDa.

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HY-P80602

	CD44 Antibody (YA801) CD44; LHR; MDU2; MDU3; MIC4; CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan Sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycopr	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	CD44 Antibody (YA801) is a non-conjugated and Mouse origined monoclonal antibody about 82 kDa, targeting to CD44 (2H12). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P80062

	CD44 Antibody LHR antibody; BA-1 antibody; CD 44 antibody; CD44 antibody; CD44 antigen antibody; CD44 molecule (Indian blood group) antibody; CD44 molecule antibody; CD44_HUMAN antibody; CDw44 antibody; Cell surface glycoprotein CD44 antibody; chondroitin Sulfate proteoglycan 8 antibody; CSPG8 antibody; ECMR-III antibody; Epican antibody; Extracellular matrix receptor III antibody; GP90 lymphocyte homing/adhesion receptor antibody; HCELL antibody; hematopoietic cell E- and L-selectin ligand antibody; Heparan Sulfate proteoglycan antibody; Hermes antigen antibody; homing function and Indian blood group system antibody; HSA antibody; HUTCH-I antibody; HUTCH1 antibody; Hyaluronate receptor antibody; IN antibody; MC56 antibody; MDU2 antibody; MDU3 antibody; MGC10468 antibody; MIC4 antibody; MUTCH1 antibody; PGP-1 antibody; PGP-I antibody; PGP1 antibody; Phagocytic glycoprotein 1 antibody; Phagocytic glycoprotein I antibody; Soluble CD44 antibody;	WB, IHC-P, FC	Human, Mouse
	CD44 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 82 kDa, targeting to CD44. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P83707M

	Human CD138 Antibody (PE) CD_antigen antibody; CD138 antibody; CD138 antigen antibody; Heparan Sulfate proteoglycan fibroblast growth factor receptor antibody; SDC antibody; Sdc1 antibody; SDC1_HUMAN antibody; SYND1 antibody; Syndecan 1 antibody; Syndecan antibody; syndecan proteoglycan 1 antibody; Syndecan-1 antibody	FC	Human
	CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

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Heparan Sulfate

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