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Results for "

M4 mAChR

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

1

Peptides

6

Natural
Products

4

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147028
    M4 mAChR agonist-1

    		mAChR Neurological Disease
    M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4 .
    M4 mAChR agonist-1
  • HY-119226
    VU0152099

    		mAChR Neurological Disease
    VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 µM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine .
    VU0152099
  • HY-150018
    N-Demethyl MK-6884

    		mAChR Neurological Disease
    N-Demethyl MK-6884 (compound 34) is a potent M4 mAChR allosteric modulator. N-Demethyl MK-6884 can be used in the studies of alzheimer's disease and other diseases mediated by the M4 mAChR .
    N-Demethyl MK-6884
  • HY-160440
    rel-VU6021625

    		Others Others
    rel-VU6021625 is the less active relative configuration of VU6021625 (HY-160440A). VU6021625 is a potent and selective mAChR M4 antagonist with IC50 values of 0.44 nM and 57 nM for human M4, rat M4, respectively .
    rel-VU6021625
  • HY-B1205
    Atropine
    Maximum Cited Publications
    16 Publications Verification

    Tropine tropate; DL-Hyoscyamine

    		 mAChR Endogenous Metabolite Cardiovascular Disease Neurological Disease
    Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .
    Atropine
  • HY-14563
    VU10010

    		mAChR Neurological Disease
    VU10010 is a potent, highly selective and allosteric M4 mAChR potentiator with an EC50 of 400 nM. VU10010 binds to an allosteric site on M4 mAChR and increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus .
    VU10010
  • HY-B0394
    Atropine sulfate monohydrate
    Maximum Cited Publications
    16 Publications Verification

    Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate

    		 mAChR Cardiovascular Disease Neurological Disease
    Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .
    Atropine sulfate monohydrate
  • HY-159177
    M4 mAChR Modulator-1

    		mAChR Neurological Disease
    M4 mAChR Modulator-1 (compound 23i) is a M4 mAChR positive allosteric modulator (PAM). M4 mAChR Modulator-1 exhibits significantly greater cooperativity with ACh in β-arrestin recruitment over G protein activation. M4 mAChR Modulator-1 displays weak PAM effect in G protein-mediated responses, but strong PAM effect in β-arrestin recruitment .
    M4 mAChR Modulator-1
  • HY-160440A
    VU6021625

    		mAChR Neurological Disease
    VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC50 value of 0.44 nM, 57 nM for human M4 and rat M4, respectively .
    VU6021625
  • HY-149732
    M1/M4 muscarinic agonist 3

    		mAChR Neurological Disease
    M1/M4 muscarinic agonist 3 (compound 44) is a muscarinic mAChR M1/M4 agonist with EC50s of 31 nM and 9.3 nM, respectively .
    M1/M4 muscarinic agonist 3
  • HY-B1205A
    Atropine sulfate
    Maximum Cited Publications
    16 Publications Verification

    Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol

    		 mAChR Cardiovascular Disease Neurological Disease
    Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .
    Atropine sulfate
  • HY-B1205B
    Atropine hydrobromide

    Tropine tropate hydrobromide; DL-Hyoscyamine hydrobromide

    		 mAChR Cardiovascular Disease Neurological Disease
    Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia .
    Atropine hydrobromide
  • HY-112209
    VU0467154
    1 Publications Verification

    		 mAChR Neurological Disease
    VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.
    VU0467154
  • HY-149731
    M1/M2/M4 muscarinic agonist 2

    		mAChR Neurological Disease
    M1/M2/M4 muscarinic agonist 2 (compound 43) is a muscarinic mAChR M1/M2/M4 agonist with EC50s of 30 nM, 200 nM and 6.2 nM, respectively .
    M1/M2/M4 muscarinic agonist 2
  • HY-149733
    M1/M2/M4 muscarinic agonist 3

    		mAChR Neurological Disease
    M1/M2/M4 muscarinic agonist 3 (compound 45) is a muscarinic mAChR M1/M2/M4 agonist with EC50s of 3.2 nM, 32 nM and 1.7 nM, respectively .
    M1/M2/M4 muscarinic agonist 3
  • HY-B1205R
    Atropine (Standard)

    Tropine tropate (Standard); DL-Hyoscyamine (Standard)

    		 mAChR Endogenous Metabolite Cardiovascular Disease Neurological Disease
    Atropine (Standard) is the analytical standard of Atropine. This product is intended for research and analytical applications. Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .
    Atropine (Standard)
  • HY-119333
    NNC 11-1607

    		mAChR Neurological Disease
    NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia .
    NNC 11-1607
  • HY-155367
    mAChR antagonist 1

    		mAChR Neurological Disease
    mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively .
    mAChR antagonist 1
  • HY-B1205AR
    Atropine sulfate (Standard)

    		mAChR Cardiovascular Disease Neurological Disease
    Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .
    Atropine sulfate (Standard)
  • HY-B0394R
    Atropine sulfate monohydrate (Standard)

    		mAChR Cardiovascular Disease Neurological Disease
    Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .
    Atropine sulfate monohydrate (Standard)
  • HY-141711
    VU6028418

    		mAChR Neurological Disease
    VU6028418 is a potent, highly selective and orally bioavailable M4 mAChR antagonist with an IC50 of 4.1 nM against hM4 .
    VU6028418
  • HY-B0406A
    Bethanechol chloride
    1 Publications Verification

    Carbamyl-β-methylcholine chloride

    		 mAChR Neurological Disease Cancer
    Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system .
    Bethanechol chloride
  • HY-B0406
    Bethanechol

    Carbamyl-β-methylcholine

    		 mAChR Neurological Disease Cancer
    Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system .
    Bethanechol
  • HY-118356
    WIN 62,577

    		Neurokinin Receptor mAChR Neurological Disease
    WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.
    WIN 62,577
  • HY-B0406AS
    Bethanechol-d6 chloride

    Carbamyl-β-methylcholine-d6 (chloride)

    		 mAChR Neurological Disease
    Bethanechol-d6 (chloride) is the deuterium labeled Bethanechol chloride. Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].
    Bethanechol-d6 chloride
  • HY-12567
    ML375

    VU0483253

    		 mAChR Neurological Disease
    ML375 (VU0483253) is a potent, highly selective, brain-penetrant and orally active M5 mAChR negative allosteric modulator (NAM) with IC50s of 300 nM and 790 nM for human and rat M5, respectively. ML375 is inactive at human and rat M1-M4 .
    ML375
  • HY-108171A
    Hexocyclium methylsulfate

    		mAChR Inflammation/Immunology
    Hexocyclium methylsulfate is a potent mAChR antagonist with pKi values of 8.9, 7.7, 8.4, 8.8 for M1, M2, M3, and M4 subtype, respectively. Hexocyclium methylsulfate has the potential for the research of duodenal ulcer and irritable bowel syndrome .
    Hexocyclium methylsulfate
  • HY-107651
    VU 0365114
    1 Publications Verification

    		 mAChR Metabolic Disease
    VU 0365114 is a selective mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM, and >30 μM for M1, M2, M3 and M4 receptors. VU 0365114 increases insulin secretion stimulated by ACh in human β-cells .
    VU 0365114
  • HY-A0030
    Fesoterodine fumarate

    		mAChR Neurological Disease Metabolic Disease
    Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB) .
    Fesoterodine fumarate
  • HY-70053
    Fesoterodine

    		mAChR Neurological Disease Metabolic Disease
    Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB) .
    Fesoterodine
  • HY-12158
    VU0238441

    		mAChR Neurological Disease
    VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively .
    VU0238441
  • HY-70053A
    Fesoterodine L-mandelate

    		mAChR Neurological Disease Metabolic Disease
    Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB) .
    Fesoterodine L-mandelate
  • HY-76570
    (Rac)-5-Hydroxymethyl Tolterodine

    (Rac)-Desfesoterodine; (Rac)-PNU-200577

    		 mAChR Neurological Disease
    (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .
    (Rac)-5-Hydroxymethyl Tolterodine
  • HY-76570A
    (Rac)-5-Hydroxymethyl Tolterodine hydrochloride

    (Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride

    		 mAChR Neurological Disease
    (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research .
    (Rac)-5-Hydroxymethyl Tolterodine hydrochloride
  • HY-A0030S
    Fesoterodine-d7 fumarate

    		mAChR Metabolic Disease
    Fesoterodine-d7 (fumarate) is the deuterium labeled Fesoterodine fumarate[1]. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB)[2][3].
    Fesoterodine-d7 fumarate
  • HY-76570S
    (Rac)-5-Hydroxymethyl Tolterodine-d14

    (Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14

    		 mAChR Neurological Disease
    (Rac)-5-Hydroxymethyl Tolterodine-d14 is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].
    (Rac)-5-Hydroxymethyl Tolterodine-d14
  • HY-76570S1
    5-Hydroxymethyl Tolterodine-d14 formate

    		Isotope-Labeled Compounds mAChR Neurological Disease
    5-Hydroxymethyl Tolterodine-d14 (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].
    5-Hydroxymethyl Tolterodine-d14 formate
  • HY-P5846
    Muscarinic toxin 3

    MT3

    		 mAChR Adrenergic Receptor Neurological Disease
    Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC50s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M1, M4, α1A, α1B, α1D,α2A,α2B and α2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity .
    Muscarinic toxin 3

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