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MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalphain vivo .
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalphain vivo .
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .
Methylpiperidino pyrazole (MPP) is a potent and selective ER (estrogen receptor) modulator. Methylpiperidino pyrazole induces significant apoptosis in the endometrial cancer and oLE cell lines. Methylpiperidino pyrazole reverses the the positive effects of beta-estradiol. Methylpiperidino pyrazole has mixed agonist/antagonist action on murine uterine ERalpha in vivo .
MPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP3 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP4 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP7 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPTP hydrochloride is a brain penetrant dopamine neurotoxin. MPTP hydrochloride can be used to induces Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP+, induces apoptosis . MPTP hydrochloride has been verified by MCE with professional biological experiments.
Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP+ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease .
L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans .
LZWL02003 is an anti-neuroinflammatory agent. LZWL02003 has protective effect on MPP+-induced neuronal damage, and reduces the expression of ROS. LZWL02003 improves cognition, memory, learning, and athletic ability in a Rotenone (HY-B1756)-induced PD rat model. LZWL02003 can be used for research of neurodegenerative disease .
c-ABL-IN-6 (compound A6) is a c-ABL inhibitor with IC50 value of 16.6 nM. c-ABL-IN-6 displays higher neuroprotective effects against SH-SY5Y cell death induced by MPP+ (HY-W008719). c-ABL-IN-6 can be used for the research of neurodegenerative disorder .
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .
Taltirelin (TA0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of PD. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .
RWJ-52353 hydrochloride is an orally potent, highly selective α2D adrenergic receptor agonist (Ki: 1.5 nM) with potential analgesic effects. RWJ-52353 hydrochloride demonstrated analgesic activity in abdominal tests in rats and mice, and improved agitation in mice in the hot plate test and tail flick test. RWJ-52353 hydrochloride also regulates the organic cation transporter (OCT) subtype, inhibiting rOCT1 and rOCT2 with IC50s of 100 μM and 20 μM respectively; it also activates rOCT3, affecting [3H]-1- in cells. Methyl-4-phenylpyridinium ([3H]MPP) transport .
AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with Ki of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP+. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) .
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of PD. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .
Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP+ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease .
Myelin protein P0 (MPZ) is a crucial adhesion molecule essential for normal myelination in the peripheral nervous system. Acting as an adhesion mediator between adjacent myelin wraps, MPZ plays a pivotal role in myelin compaction. Its homodimeric and homotetrameric structures underscore its significance in establishing necessary cellular interactions for myelin formation and integrity in the peripheral nervous system. Myelin protein P0/MPZ Protein, Human (HEK293, His) is the recombinant human-derived Myelin protein P0/MPZ protein, expressed by HEK293 , with C-6*His labeled tag.
FOXM1 is an important transcription factor that controls cell cycle gene expression critical for DNA replication and mitosis, underscoring its critical role in cellular processes. In addition to cell proliferation, FOXM1 contributes to DNA break repair and DNA damage checkpoint responses. FOXM1 Protein, Human (His, SUMO-Myc) is the recombinant human-derived FOXM1 protein, expressed by E. coli , with N-10*His, C-Myc, N-SUMO labeled tag.
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
FOXM1 Antibody (YA1112) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1112), targeting FOXM1. FOXM1 Antibody (YA1112) can be used for IHC-P experiment in human background.
MPP1 Antibody (YA3077) is a biotin-conjugated non-conjugated IgG antibody, targeting MPP1, with a predicted molecular weight of 52 kDa (observed band size: 55 kDa). MPP1 Antibody (YA3077) can be used for WB experiment in human background.
Myelin Protein Zero Antibody (YA3278) is a biotin-conjugated non-conjugated IgG antibody, targeting Myelin Protein Zero, with a predicted molecular weight of 28 kDa (observed band size: 28 kDa). Myelin Protein Zero Antibody (YA3278) can be used for WB experiment in rat background.
p60 CAF1 Antibody (YA1999) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1999), targeting p60 CAF1, with a predicted molecular weight of 61 kDa (observed band size: 70 kDa). p60 CAF1 Antibody (YA1999) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.
Myelin Protein Zero Rabbit pAb; peripheral myelin prothein Zero; MPZ; MPP; Myelin P0 protein; CHM; CMT1; CMT1B; DSS; MYELIN GLYCOPROTEIN P-ZERO; MYELIN PROTEIN PERIPHERAL; Myelin protein zero; P0; MYP0_HUMAN.
WB
Rat
MPZ Antibody is a rabbit-derived non-conjugated IgG antibody, targeting MPZ, with a predicted molecular weight of 28 kDa (observed band size: 28 kDa). MPZ Antibody can be used for WB experiments in rat backgrounds.
ILF3; DRBF; MPHOSPH4; NF90; Interleukin enhancer-binding factor 3; Double-stranded RNA-binding protein 76; DRBP76; M-phase phosphoprotein 4; MPP4; Nuclear factor associated with dsRNA; NFAR; Nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80
WB, IHC-P, ICC/IF, IP, FC
Human, Mouse
ILF3 Antibody (YA1904) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1904), targeting ILF3, with a predicted molecular weight of 95 kDa (observed band size: 95 kDa). ILF3 Antibody (YA1904) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse background.
MPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP3 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP4 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MPP7 Human Pre-designed siRNA Set A contains three designed siRNAs for MPP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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