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Results for "

N-desmethyl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Androgen Receptor (4) Biochemical Assay Reagents (2) c-Kit (1) CD38 (1) CFTR (2) Cholecystokinin Receptor (1) Cholinesterase (ChE) (1) Cytochrome P450 (6) Drug Metabolite (22) EGFR (1) Endogenous Metabolite (2) Ferroportin (1) GABA Receptor (2) Histamine Receptor (1) iGluR (1) Isotope-Labeled Compounds (40) mAChR (1) MMP (1) nAChR (1) Opioid Receptor (2) Parasite (1) Phosphodiesterase (PDE) (4) PPAR (1) Raf (1) Serotonin Transporter (3) Vasopressin Receptor (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (3) Endocrinology (1) Infection (3) Inflammation/Immunology (3) Metabolic Disease (9) Neurological Disease (22)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12388A

N-Desmethyl clomipramine hydrochloride desmethylclomipramine hydrochloride; Norclomipramine hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .

HY-70002A

N-desmethyl Enzalutamide N-desmethyl MDV 3100	Androgen Receptor	Cancer
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-70002AS

N-desmethyl Enzalutamide-d6 N-desmethyl MDV 3100-d₆	Androgen Receptor	Cancer
N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

HY-12388AS

N-Desmethyl clomipramine-d3 hydrochloride desmethylclomipramine-d₃ (hydrochloride)；Norclomipramine-d₃ hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]

HY-160849

N-Desmethyl Rilmazolam	GABA Receptor	Others Metabolic Disease
N-desmethyl Rilmazolam, a triazolobenzodiazepine, serves as an analytical reference standard. N-desmethyl Rilmazolam is an active metabolite derived from rilmazafone (HY-106547). N-desmethyl Rilmazolam is designed for use in research and forensic settings .

HY-G0010

*Netupitant metabolite N-desmethyl* Netupitant** N-desmethyl Netupitant	Drug Metabolite	Neurological Disease Metabolic Disease
N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.

HY-137200

N-Desmethyl Bendamustine	Drug Metabolite	Cancer
N-Desmethyl Bendamustine is a metabolite of Bendamustine (HY-13567). N-Desmethyl Bendamustine has cytotoxic effect in several lymphoma cell lines and peripheral blood lymphocytes .

HY-W013775R

N-Desmethyl ofloxacin (Standard)	Biochemical Assay Reagents	Others
N-Desmethyl ofloxacin (Standard) is the analytical standard of N-Desmethyl ofloxacin. This product is intended for research and analytical applications. N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-117605R

N-Desmethyl Sildenafil (Standard)	Phosphodiesterase (PDE)	Cardiovascular Disease
N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .

HY-158192S

N-Desmethyl diltiazem-d4	Isotope-Labeled Compounds	Others
N-Desmethyl diltiazem-d₄ is deuterium labeled N-Desmethyl diltiazem .

HY-132685AS

N-Desmethyl Topotecan-d3 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl Topotecan-d3 hydrochloride is the deuterium labeled N-Desmethyl Topotecan hydrochloride .

HY-143922S

N-Desmethyl Bedaquiline-d6	Isotope-Labeled Compounds	Others
N-Desmethyl Bedaquiline-d₆ is the deuterium labeled N-Desmethyl Bedaquiline[1].

HY-132626S

N-Desmethyl Tamoxifen-d5	Isotope-Labeled Compounds	Others
N-Desmethyl Tamoxifen-d₅ is the deuterium labeled N-Desmethyl Tamoxifen[1].

HY-141750S1

N-Desmethyl Zolmitriptan-d3	Isotope-Labeled Compounds	Others
N-Desmethyl Zolmitriptan-d₃ is the deuterium labeled N-Desmethyl Zolmitriptan[1].

HY-G0010S

N-desmethyl Netupitant-d6	Isotope-Labeled Compounds Drug Metabolite	Neurological Disease Endocrinology
N-desmethyl Netupitant-d₆ is the deuterium labeled N-desmethyl Netupitant, which is a metabolite of Netupitant.

HY-132344S

N-Desmethyl asenapine-d4 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl asenapine-d₄ (hydrochloride) is the deuterium labeled N-Desmethyl asenapine hydrochloride[1].

HY-139519S

N-Desmethyl diphenhydramine-d3 hydrochloride	Histamine Receptor	Inflammation/Immunology
N-Desmethyl diphenhydramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl diphenhydramine hydrochloride[1].

HY-144143S

N-Desmethyl Olopatadine-d3 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl Olopatadine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Olopatadine hydrochloride[1].

HY-W741222S

N-Desmethyl Olopatadine-d6	Isotope-Labeled Compounds	Others
N-Desmethyl Olopatadine-d₆ is deuterium-labeled N-Desmethyl Olopatadine (HY-W741222) .

HY-W754151

N-Desmethyl apalutamide-d4	Isotope-Labeled Compounds	Others
N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-143810S

N-Desmethyl Mifepristone-d3	Isotope-Labeled Compounds	Others
N-Desmethyl Mifepristone-d₃ is the deuterium labeled N-Desmethyl Mifepristone[1]. N-Desmethyl Mifepristone-d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-143767S

N-Desmethyl Azelastine-d4-1	Isotope-Labeled Compounds	Others
N-Desmethyl Azelastine-d₄-1 is the deuterium labeled N-Desmethyl Azelastine[1].

HY-108226

*Regorafenib N-oxide and N-desmethyl* (M5)** N-desmethyl regorafenib N-oxide	Drug Metabolite Raf VEGFR c-Kit	Cancer
Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-Z3203S

N-Desmethyl Rosuvastatin-d6 disodium	Isotope-Labeled Compounds	Others
N-Desmethyl Rosuvastatin-d₆ (disodium) is the deuterium labeled N-Desmethyl Rosuvastatin disodium[1].

HY-143931S

N-Desmethyl citalopram-d4 oxalate	Isotope-Labeled Compounds	Others
N-Desmethyl citalopram-d₄ (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate[1].

HY-W662579

N-Desmethyl clotiazepam desmethylclotiazepam	Drug Metabolite	Metabolic Disease
N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam .

HY-W013775

N-Desmethyl ofloxacin	Biochemical Assay Reagents	Others
N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-Z8033

N-Desmethyl diltiazem hydrochloride	Cytochrome P450	Metabolic Disease
N-Desmethyl diltiazem hydrochloride is a substrate for CYP3A7 metabolism, which is the predominant fetal form and is minimally expressed in adults .

HY-G0017A

N-Desmethyl imatinib mesylate Norimatinib mesylate; Imatinib metabolite N-desmethyl imatinib mesylate	Drug Metabolite	Others
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-G0017

N-Desmethyl imatinib 1 Publications Verification Norimatinib; Imatinib metabolite N-desmethyl imatinib	Drug Metabolite	Others
N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-G0017S

N-Desmethyl imatinib-d8 Norimatinib-d₈; Imatinib metabolite N-desmethyl imatinib-d₈	Drug Metabolite	Cancer
N-Desmethyl imatinib-d₈ is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.

HY-W295339S

N-Desmethyl venlafaxine-d3	Isotope-Labeled Compounds	Others
N-Desmethyl venlafaxine-d₃ is a deuterium labeled compound.

HY-100647S

N-Desmethyl Nefopam-d4 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl Nefopam-d₄ (hydrochloride) is deuterium labeled N-Desmethylnefopam (hydrochloride).

HY-172004

N-Desmethyl asenapine	5-HT Receptor	Neurological Disease
N-Desmethyl asenapine is a metabolite of Asenapine (HY-10121). Asenapine, an atypical antipsychotic agent, is an antagonist of serotonin receptors, adrenoceptors, dopamine receptors and histamine receptors .

HY-120422S

N-Desmethyl Regorafenib-d3	Isotope-Labeled Compounds	Others
N-Desmethyl Regorafenib-d₃ is deuterium labeled BAY-751098.

HY-137580

N-Desmethyl Eletriptan	Cytochrome P450	Metabolic Disease
N-desmethyl Eletriptan is a metabolite of Eletriptan (HY-A0039). It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes.

HY-G0017S1

N-Desmethyl imatinib-d4 Norimatinib-d₄; Imatinib metabolite N-desmethyl imatinib-d₄	Isotope-Labeled Compounds	Others
N-Desmethyl imatinib-d₄ is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d₄ (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-144386S

N-Desmethyl L-ergothioneine methyl ester-d6	Isotope-Labeled Compounds	Others
N-Desmethyl L-ergothioneine methyl ester-d₆ is the deuterium labeled N-Desmethyl L-ergothioneine methyl ester[1].

HY-108226S

*Regorafenib N-oxide and N-desmethyl* (M5)-d3** N-desmethyl regorafenib N-oxide-d₃	Isotope-Labeled Compounds	Others
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-N7612

N-Desmethyl Galanthamine N-Norgalanthamine	Cholinesterase (ChE)	Others
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-12388AR

N-Desmethyl clomipramine (hydrochloride) (Standard) desmethylclomipramine (hydrochloride) (Standard); Norclomipramine (hydrochloride) (Standard)	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .

HY-U00199S

N-Desmethyl zopiclone-d8	Isotope-Labeled Compounds Drug Metabolite	Neurological Disease
N-Desmethyl zopiclone-d₈ is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

HY-W741626

N-Desmethyl selegiline-d5 (-)-N-desmethylselegiline-d₅	Isotope-Labeled Compounds	Others
N-Desmethyl selegiline-d5 is the deuterium labeled N-Desmethyl selegiline .

HY-118788S

N-Desmethyl rosiglitazone-d4 SB 237216-d₄	Isotope-Labeled Compounds	Others
N-Desmethyl rosiglitazone-d₄ is the deuterium labeled N-Desmethyl rosiglitazone[1].

HY-118601S

N-Desmethyl Pirenzepine-d8 LS 822-d₈	Isotope-Labeled Compounds	Others
N-Desmethyl Pirenzepine-d₈ is the deuterium labeled N-Desmethyl Pirenzepine[1].

HY-135392

N-Desmethyl Pimavanserin AC-279	Drug Metabolite	Neurological Disease
N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC₅₀ and pK_d of 8.73 and 9.3, respectively.

HY-150544S

N-Desmethyl selegiline-d5 hydrochloride (-)-N-desmethylselegiline-d₅ hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl Selegiline-dd₅ hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-117605

N-Desmethyl Sildenafil desmethylsildenafil; UK-103,320	Phosphodiesterase (PDE)	Cardiovascular Disease
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .

HY-135392S

N-Desmethyl Pimavanserin-d9 hydrochloride AC-279-d₉ hydrochloride	Isotope-Labeled Compounds	Neurological Disease
N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC₅₀ and pK_d of 8.73 and 9.3, respectively .

HY-171459

LEQ803 N-desmethyl Ribociclib	Drug Metabolite Cytochrome P450	Cancer
LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology .

Cat. No.	Product Name	Type

HY-W013775R

N-Desmethyl ofloxacin (Standard)	Biochemical Assay Reagents
N-Desmethyl ofloxacin (Standard) is the analytical standard of N-Desmethyl ofloxacin. This product is intended for research and analytical applications. N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W013775

N-Desmethyl ofloxacin	Biochemical Assay Reagents
N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

Cat. No.	Product Name	Target	Research Area

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-P4756

*N-(2-Carbamoyl-ethyl)-Val-Leu-anilide*	Peptides	Others
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-P4521

*Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt*	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7612

N-Desmethyl Galanthamine N-Norgalanthamine	Alkaloids other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Cholinesterase (ChE)
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-12388

N-Desmethyl clomipramine desmethylclomipramine; Norclomipramine	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite
Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research .

HY-N0913R

Manninotriose (Standard)	Structural Classification Polysaccharides Microorganisms other families Source classification Plants Saccharides	Endogenous Metabolite
Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

Cat. No.	Product Name	Chemical Structure

HY-70002AS

N-desmethyl Enzalutamide-d6

N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

HY-12388AS

N-Desmethyl clomipramine-d3 hydrochloride
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]

HY-143922S

N-Desmethyl Bedaquiline-d6
N-Desmethyl Bedaquiline-d₆ is the deuterium labeled N-Desmethyl Bedaquiline[1].

HY-158192S

N-Desmethyl diltiazem-d4
N-Desmethyl diltiazem-d₄ is deuterium labeled N-Desmethyl diltiazem .

HY-132685AS

N-Desmethyl Topotecan-d3 hydrochloride
N-Desmethyl Topotecan-d3 hydrochloride is the deuterium labeled N-Desmethyl Topotecan hydrochloride .

HY-132626S

N-Desmethyl Tamoxifen-d5
N-Desmethyl Tamoxifen-d₅ is the deuterium labeled N-Desmethyl Tamoxifen[1].

HY-141750S1

N-Desmethyl Zolmitriptan-d3
N-Desmethyl Zolmitriptan-d₃ is the deuterium labeled N-Desmethyl Zolmitriptan[1].

HY-G0010S

N-desmethyl Netupitant-d6
N-desmethyl Netupitant-d₆ is the deuterium labeled N-desmethyl Netupitant, which is a metabolite of Netupitant.

HY-132344S

N-Desmethyl asenapine-d4 hydrochloride
N-Desmethyl asenapine-d₄ (hydrochloride) is the deuterium labeled N-Desmethyl asenapine hydrochloride[1].

HY-139519S

N-Desmethyl diphenhydramine-d3 hydrochloride
N-Desmethyl diphenhydramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl diphenhydramine hydrochloride[1].

HY-144143S

N-Desmethyl Olopatadine-d3 hydrochloride
N-Desmethyl Olopatadine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Olopatadine hydrochloride[1].

HY-W741222S

N-Desmethyl Olopatadine-d6
N-Desmethyl Olopatadine-d₆ is deuterium-labeled N-Desmethyl Olopatadine (HY-W741222) .

HY-W754151

N-Desmethyl apalutamide-d4

N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-143810S

N-Desmethyl Mifepristone-d3
N-Desmethyl Mifepristone-d₃ is the deuterium labeled N-Desmethyl Mifepristone[1]. N-Desmethyl Mifepristone-d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-143767S

N-Desmethyl Azelastine-d4-1
N-Desmethyl Azelastine-d₄-1 is the deuterium labeled N-Desmethyl Azelastine[1].

HY-Z3203S

N-Desmethyl Rosuvastatin-d6 disodium
N-Desmethyl Rosuvastatin-d₆ (disodium) is the deuterium labeled N-Desmethyl Rosuvastatin disodium[1].

HY-143931S

N-Desmethyl citalopram-d4 oxalate
N-Desmethyl citalopram-d₄ (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate[1].

HY-G0017S

N-Desmethyl imatinib-d8
N-Desmethyl imatinib-d₈ is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.

HY-W295339S

N-Desmethyl venlafaxine-d3
N-Desmethyl venlafaxine-d₃ is a deuterium labeled compound.

HY-100647S

N-Desmethyl Nefopam-d4 hydrochloride
N-Desmethyl Nefopam-d₄ (hydrochloride) is deuterium labeled N-Desmethylnefopam (hydrochloride).

HY-120422S

N-Desmethyl Regorafenib-d3
N-Desmethyl Regorafenib-d₃ is deuterium labeled BAY-751098.

HY-G0017S1

N-Desmethyl imatinib-d4
N-Desmethyl imatinib-d₄ is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d₄ (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-144386S

N-Desmethyl L-ergothioneine methyl ester-d6
N-Desmethyl L-ergothioneine methyl ester-d₆ is the deuterium labeled N-Desmethyl L-ergothioneine methyl ester[1].

HY-108226S

*Regorafenib N-oxide and N-desmethyl* (M5)-d3**
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-U00199S

N-Desmethyl zopiclone-d8
N-Desmethyl zopiclone-d₈ is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

HY-W741626

N-Desmethyl selegiline-d5
N-Desmethyl selegiline-d5 is the deuterium labeled N-Desmethyl selegiline .

HY-118788S

N-Desmethyl rosiglitazone-d4
N-Desmethyl rosiglitazone-d₄ is the deuterium labeled N-Desmethyl rosiglitazone[1].

HY-118601S

N-Desmethyl Pirenzepine-d8
N-Desmethyl Pirenzepine-d₈ is the deuterium labeled N-Desmethyl Pirenzepine[1].

HY-150544S

N-Desmethyl selegiline-d5 hydrochloride
N-Desmethyl Selegiline-dd₅ hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135392S

N-Desmethyl Pimavanserin-d9 hydrochloride
N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC₅₀ and pK_d of 8.73 and 9.3, respectively .

HY-142283BS

N-Desmethyl dosimertinib-d5
N-Desmethyl dosimertinib-d₅ is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].

HY-117605S

N-Desmethyl Sildenafil-d8
N-Desmethyl Sildenafil-d₈ is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2][3].

HY-12388S

N-Desmethyl clomipramine-d7
N-Desmethyl clomipramine-d₇ (Desmethylclomipramine-d₇) is deuterium labeled N-Desmethyl clomipramine. Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research .

HY-12388S1

N-Desmethyl clomipramine-d6
N-Desmethyl clomipramine-d₆ (Desmethylclomipramine-d₆) is deuterium labeled N-Desmethyl clomipramine. Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research .

HY-135331S

N-Desmethyl-Apalutamide-15N,d4

N-Desmethyl-Apalutamide-15N,d4 is the ¹⁵N and deuterium labeled isotope of N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-131332S1

N-Desmethyl ulipristal acetate-d3
N-Desmethyl ulipristal-d₃ ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl-d₃) acetate is deuterium labeled N-Desmethyl ulipristal acetate ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl) .

HY-128038S

N-Desmethyl-loperamide-d3
N-Desmethyl-loperamide-d₃ is the deuterium labeled N-Desmethyl-loperamide[1].

HY-132709S

N-Desmethyl-diltiazem-d4 hydrochloride
N-Desmethyl-diltiazem-d₄ (hydrochloride) is the deuterium labeled N-Desmethyl-diltiazem hydrochloride[1].

HY-157207S

N-Desmethyl-Atomoxetine labeled-d5 hydrochloride
N-Desmethyl-Atomoxetine labeled-d5 hydrochloride is the deuterium labeled N-Desmethyl-Atomoxetine labeled hydrochloride .

HY-108226S1

*Regorafenib N-oxide and N-desmethyl* (M5)-13C6**
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5)[1].

HY-144144S

*(E)-N-Desmethyl* Olopatadine-d3 hydrochloride**
(E)-N-Desmethyl Olopatadine-d₃ (hydrochloride) is the deuterium labeled (E)-N-Desmethyl Olopatadine.

HY-143949S

*(Rac)-N-desmethyl* Dapoxetine-d7 hydrochloride**
(Rac)-N-desmethyl Dapoxetine-d7 hydrochloride is the deuterium labeled (Rac)-N-desmethyl Dapoxetine hydrochloride[1].

HY-143834S

*O-Desacetyl-N-desmethyl* Diltiazem-d3**
O-Desacetyl-N-desmethyl Diltiazem-d₃ is the deuterium labeled O-Desacetyl-N-desmethyl Diltiazem[1].

HY-139689S

*rac-trans-N-Desmethyl* sertraline-d3 hydrochloride**
rac-trans-N-Desmethyl sertraline-d₃ (hydrochloride) is the deuterium labeled rac-trans-N-Desmethyl sertraline hydrochloride[1].

HY-W753602

*Acetamiprid-N-desmethyl-13C,d3*
Acetamiprid-N-desmethyl- ¹³C,d3 is the ¹³C and deuterium labeled isotope of Acetamiprid-N-desmethyl( ¹³C,d3)(HY-B0823).Acetamiprid is a nAChR agonist that has been implicated in neuromuscular and reproductive disorders.

Cat. No.	Product Name		Classification

HY-150544S

N-Desmethyl selegiline-d5 hydrochloride (-)-N-desmethylselegiline-d₅ hydrochloride		Alkynes
N-Desmethyl Selegiline-dd₅ hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride[1]. N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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