(S)-Norzopiclone  (Synonyms: (S)-N-Desmethyl zopiclone; SEP-174559)

(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABA_A receptor and inhibits nACh and NMDA receptors^[1].

Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABA_A receptor currents evoked by subsaturating concentrations of GABA^[1].
(S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABA_A receptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors^[1].
In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

374.78

C₁₆H₁₅ClN₆O₃

151776-26-0

O=C(O[C@@H]1N(C(C2=NC=CN=C21)=O)C3=NC=C(C=C3)Cl)N4CCNCC4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mark W Fleck. Molecular actions of (S)-desmethylzopiclone (SEP-174559), an anxiolytic metabolite of zopiclone. J Pharmacol Exp Ther. 2002 Aug;302(2):612-8.  [Content Brief]