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Results for "

NEU

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (8) EGFR (6) Endogenous Metabolite (7) Fluorescent Dye (1) iGluR (2) Influenza Virus (2) Melatonin Receptor (1) P2X Receptor (1) Paraptosis (1) Parasite (1) Radionuclide-Drug Conjugates (RDCs) (1) Ser/Thr Protease (1) Sialyltransferase (1) Small Interfering RNA (siRNA) (4) Sodium Channel (1) Transmembrane Glycoprotein (1) TRP Channel (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (5)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (2)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-105285

Piromelatine NEU-P11	Melatonin Receptor 5-HT Receptor P2X Receptor TRP Channel Sodium Channel	Neurological Disease
Piromelatine (Neu-P11) is a melatonin MT₁/MT₂ receptor agonist, serotonin 5-HT_1A/5-HT_1D agonist, and serotonin 5-HT_2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities .

HY-161943

NEU3-IN-1	Influenza Virus	Neurological Disease
NEU3-IN-2 (compound 963) is a *NEU3* inhibitor (Ki: 0.12 μM; IC₅₀: 0.31 μM) based on the 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) scaffold and is a C9 biphenylcarbamate derivative. NEU is a human neuraminidase with 4 isozymes; NEU3-IN-2 is an important tool for studying the function of NEU3 isozymes; its amide and triazole linker analogs are selective for NEU1 and NEU4 isozymes, respectively .

HY-125084

NEU617	Parasite	Infection
NEU617 is an anti-parasite agent. NEU617 inhibits the proliferation for the HAT (human African trypanosomiasis) pathogen (EC₅₀: 42 nM for Trypanosoma brucei, 1.8 μM for T. cruzi). NEU617 is a derivative of Lapatinib (HY-50898) .

HY-129288

GW837016X NEU-391	EGFR Paraptosis	Infection
GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis .

HY-RS09215

NEU1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEU1 Human Pre-designed siRNA Set A contains three designed siRNAs for NEU1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEU1 Human Pre-designed siRNA Set A NEU1 Human Pre-designed siRNA Set A

HY-RS09216

NEU2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEU2 Human Pre-designed siRNA Set A contains three designed siRNAs for NEU2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEU2 Human Pre-designed siRNA Set A NEU2 Human Pre-designed siRNA Set A

HY-RS09217

NEU3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEU3 Human Pre-designed siRNA Set A contains three designed siRNAs for NEU3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEU3 Human Pre-designed siRNA Set A NEU3 Human Pre-designed siRNA Set A

HY-RS09218

NEU4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEU4 Human Pre-designed siRNA Set A contains three designed siRNAs for NEU4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEU4 Human Pre-designed siRNA Set A NEU4 Human Pre-designed siRNA Set A

HY-N10626

Neu5Gcα(2-6) N-Glycan	Others	Others
Neu5Gcα(2-6) N-Glycan is an glycan. Neu5Gcα(2-6) N-Glycan can be used for the various biochemical studies .

HY-148392

Neu5Gcα(2-6) N-Glycan-Asn	Biochemical Assay Reagents	Others
Neu5Gcα(2-6) N-Glycan-Asn is a glycopeptide. Neu5Gcα(2-6) N-Glycan-Asn can be used for various biochemical studies .

HY-125798

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 2 Publications Verification NEU5Ac2en; DANA	Influenza Virus	Infection
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC₅₀s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .

HY-171289

Neu5Acα2-6GalNAcα1-4GlcNac	Biochemical Assay Reagents	Others
Neu5Acα2-6GalNAcα1-4GlcNac is the derivative of Neu5Acα2-6GalNAcα. Neu5Acα2-6GalNAcα can be used for synthesis of glycopolymer .

HY-N10628

Neu5Acα(2-6) N-Glycan	Others	Others
Neu5Acα(2-6) N-Glycan is a N-Glycan, and can be used for labeling and modification of proteins.

HY-166965

Neu5Gc(α2,6)N-Acetylgalactosamine	Biochemical Assay Reagents	Others
Neu5Gc(α2,6)N-Acetylgalactosamine is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W145531

Neu5GcAc[1Me,478Ac,9N3]-β-SPh	Biochemical Assay Reagents	Others
Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W145561

Neu5Acα(2-3)Galβ MP glycoside NEU5Ac alpha(2-3)Gal beta MP glycoside	Biochemical Assay Reagents	Others
Neu5Acα(2-3)Galβ MP Glycoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145609

Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP	Biochemical Assay Reagents	Others
Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-106408A

Nelonemdaz potassium Salfaprodil; NEU2000 potassium	iGluR	Neurological Disease
Nelonemdaz (Salfaprodil) potassium is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz potassium is also a free radical scavenger. Nelonemdaz potassium has excellent neuroprotection against NMDA- and free radical-induced cell death .

HY-106408

Nelonemdaz Salfaprodil free base; NEU2000	iGluR	Neurological Disease
Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death .

HY-164390

6′SLN NEU5Acα2-6Galβ1-4GlcNAc	Endogenous Metabolite	Infection Cancer
6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .

HY-154790

STn/sialyl-Tn NEU5Aca2-6GalNAc-a-Ser/Thr	Ser/Thr Protease	Cancer
STn/sialyl-Tn is a sialic acid associated with breast cancer and its expression is closely related to HER2-pos. STn/sialyl-Tn can be used as a marker to count cells in malignant nipple discharge (PND) .

HY-D2260

*hMSCs-Neu* perchlorate**	Fluorescent Dye	Neurological Disease
hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research .

HY-110288

*3FAx-Neu5Ac*	Sialyltransferase	Metabolic Disease
3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X .

HY-32264

*X-Neu5Ac sodium* X-NEUNAc	Bacterial	Others
X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a K_m of 0.89 mM for neuraminidase.

HY-P1855

*HER2/neu* (654-662) GP2**	EGFR	Cancer
HER2/neu (654-662) GP2 is a nine amino acid peptide derived from the human epidermal growth factor receptor 2 (HER2/nue, 654–662), induces HLA-A2-restricted cytotoxic T lymphocytes (CTL) reactive to various epithelial cancers .

HY-W145540

*Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP*	Biochemical Assay Reagents	Others
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145622

*Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP* Gal beta(1-3)[NEU5Ac alpha(2-6)]GlcNAc-beta-pNP	Biochemical Assay Reagents	Others
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-112942A

CMP-Sialic acid sodium salt 1 Publications Verification CMP-NEU5Ac sodium salt	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-112942

CMP-Sialic acid CMP-NEU5Ac	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-P990238

*Anti-Human/Rat HER2 (neu) Antibody (7.16.4)*	EGFR	Others
Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to human/rat HER2.

HY-P10569

Biotin HER-2 substrate peptide	EGFR	Cancer
Biotin HER-2 substrate peptide is a substrate of Her4 and Her2/neu tyrosine kinase with a K_m value of 60 μm for Her2/neu kinase domain .

HY-P5745

TYVPANASL	Transmembrane Glycoprotein	Cancer
TYVPANASL is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL can be used to prepare J-LEAPS vaccine .

HY-P5742A

ELAAWCRWGFLLALLPPGIAG TFA	EGFR	Cancer
ELAAWCRWGFLLALLPPGIAG TFA (P5) is derived from rat HER2/neu protein with 21 amino acid length (aa 5-25). ELAAWCRWGFLLALLPPGIAG TFA can induce cytotoxic T lymphocyte (CTL) responses in mice bearing HER2-positive tumours .

HY-100395

F16	Apoptosis	Cancer
F16 is a potent growth inhibitor of the *neu*-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines.

HY-160821A

N-Acetylmannosamine 6-phosphate sodium salt ManNAc-6P sodium salt	Endogenous Metabolite	Others
N-Acetylmannosamine 6-phosphate sodium salt is a metabolic intermediate in the breakdown of sialic acid (Neu5Ac) by Staphylococcus aureus. N-Acetylmannosamine 6-phosphate sodium salt reduces the binding ability of transcriptional regulator NanR to DNA, and thus regulates the metabolic pathway of sialic acid .

HY-W087187

DOTAGA-anhydride	Radionuclide-Drug Conjugates (RDCs) EGFR	Cancer
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.

HY-121605

RL71	Others	Cancer
RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks .

HY-P2977

N-Acetylneuraminate lyase (CgNal) Sialic acid aldolase (CgNal)	Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-E70019

alpha-2-3,6-sialidase (BiNanH2)	Endogenous Metabolite	Metabolic Disease
alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors .

HY-151852

9AzNue5Ac	Endogenous Metabolite	Cardiovascular Disease
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Anti-Pancreatic Cancer Compound Library	3,155 compounds
Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer. MCE offers a unique collection of 3,155 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

*X-Neu5Ac sodium* X-NEUNAc	Fluorescent Dyes/Probes
X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a K_m of 0.89 mM for neuraminidase.

*hMSCs-Neu* perchlorate**	Fluorescent Dyes/Probes
hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research .

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