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EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1(NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects [1].
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1(NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer [1] .
NRP1 Human Pre-designed siRNA Set A contains three designed siRNAs for NRP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC50s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis[1].
CAY10781 (Compound 11) is an inhibitor of the neuropilin-1(NRP-1) and VEGF-A interaction. CAY10781 inhibits VEGF-A-induced phosphorylation of VEGFR2 in Catecholamine A-differentiated (CAD) cells [1]< sup>.
EG01377 is a potent, bioavailable and selective inhibitor of neuropilin-1(NRP1), with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. EG01377 has antiangiogenic, antimigratory, and antitumor effects [1].
tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. tLyP-1 peptide specifically binds to NRP-1 to target tumor cells [1].
EG00229 is a neuropilin 1 (NRP1) receptor antagonist. EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2 [1].
CK3 peptide is an NRP-1 targeting peptide with the amino acid sequence CLKADKAKC. The CK3 peptide specifically binds to NRP-1 to target breast cancer cells. Single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging show significant accumulation of CK3 peptide in xenograft tumors in nude mice. CK3 peptide can be used for molecular imaging studies of breast cancer.
ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis [1]. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes .
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors [1] .
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors [1] .
iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers agents deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity [1].
tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. tLyP-1 peptide specifically binds to NRP-1 to target tumor cells [1].
CK3 peptide is an NRP-1 targeting peptide with the amino acid sequence CLKADKAKC. The CK3 peptide specifically binds to NRP-1 to target breast cancer cells. Single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging show significant accumulation of CK3 peptide in xenograft tumors in nude mice. CK3 peptide can be used for molecular imaging studies of breast cancer.
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1(NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer [1] .
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Neuropilin-1 Protein, Human (Biotinylated, HEK293, Avi-His) is 623 a.a., with molecular weight of 85-100 kDa.
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (HEK293, His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuropilin-1 Protein, Human (HEK293, His) is 623 a.a., with molecular weight of 85-100 kDa.
Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis.It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage.Neuropilin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag.
Neuropilin-1 Protein, a transmembrane glycoprotein, regulates axon guidance, angiogenesis, neuronal development, and immune responses. Neuropilin-1 can interacts with VEGF and semaphorins, and promote the growth, survival, and self-renewal of tumors. Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 and Epstein-Barr virus (EBV) infectivity. Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway. Neuropilin-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag.
Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis.It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage.Neuropilin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-mFc labeled tag.
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag and V179A, , , , mutation. The total length of Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is 623 a.a., with molecular weight of ~73.1 kDa.
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (HEK293, Fc) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Neuropilin-1 Protein, Human (HEK293, Fc) is 623 a.a., with molecular weight of 116-130 kDa.
Neuropilin-1 protein is a cell surface receptor that plays multiple roles in cardiovascular development, angiogenesis, and neuronal circuit formation. It mediates chemical repulsion by recognizing ligands with CendR motifs, leading to internalization and vascular leakage. Neuropilin-1 Protein, Rat (HEK293, His) is the recombinant rat-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag and K811R, P812-G828 delet.
Neuropilin-1 protein plays an important role by binding to VEGF-165, possibly inhibiting its cellular binding and inducing apoptosis. This dual function suggests its role in regulating VEGF-mediated processes. Neuropilin-1 Protein, Human (V179A, HEK293, Fc) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-hFc labeled tag and V179A, , , , mutation. The total length of Neuropilin-1 Protein, Human (V179A, HEK293, Fc) is 623 a.a., with molecular weight of ~107.4 kDa.
Neuropilin 1 Antibody (YA1831) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1831), targeting Neuropilin 1, with a predicted molecular weight of 103 kDa (observed band size: 125-135 kDa). Neuropilin 1 Antibody (YA1831) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
NRP1 Human Pre-designed siRNA Set A contains three designed siRNAs for NRP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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