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NSPs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Antibiotic (1) Bacterial (1) Bcl-2 Family (2) Biochemical Assay Reagents (1) Caspase (2) Cathepsin (2) DNA Methyltransferase (4) DNA/RNA Synthesis (1) Ferroptosis (2) Fluorescent Dye (2) Histone Methyltransferase (1) Influenza Virus (1) Phosphodiesterase (PDE) (1) SARS-CoV (49) Sirtuin (1) Tau Protein (2) Virus Protease (4)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (50) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0893

NSP-SA-NHS	Fluorescent Dye	Others
NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed .

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

HY-150622

*SARS-CoV-2 nsp13-IN-1*	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent *nsp13* (non-structural protein 13) inhibitor. SARS-CoV-2 nsp13-IN-1 only inhibits nsp13 ssDNA ⁺ ATPase, with an IC₅₀ of 6 μM. SARS-CoV-2 nsp13-IN-1 does not inhibit ssDNA ^- ATPase. SARS-CoV-2 nsp13-IN-1 can be used for COVID-19 research .

HY-150062

*SARS-CoV-2 nsp3-IN-1*	SARS-CoV	Infection
SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (*SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC₅₀* value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1 .

HY-124654

SS148	SARS-CoV	Metabolic Disease
SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC₅₀ of 1.2 μM .

HY-158322

nsp12-IN-1	SARS-CoV	Infection
Nsp12-IN-1 is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus .

HY-150681

*SARS-CoV-2 nsp14-IN-2*	SARS-CoV	Infection
SARS-CoV-2 nsp14-IN-2 is a potent *SARS-CoV-2 Nsp14 methyltransferase* inhibitor with an IC₅₀ value of 0.093 µM. SARS-CoV-2 nsp14-IN-2 shows antiviral activity. SARS-CoV-2 nsp14-IN-2 shows plasma and liver S9 stability. SARS-CoV-2 nsp14-IN-2 has the potential for the research of COVID-19 .

HY-155679

*SARS-CoV-2 nsp14-IN-4*	SARS-CoV	Infection
SARS-CoV-2 nsp14-IN-4 (Compound 12q) is an inhibitor of *SARS-CoV-2 nsp14 methyltransferase* (IC₅₀=19 nM). SARS-CoV-2 nsp14-IN-4 is non-cytotoxic and cell-permeable. SARS-CoV-2 nsp14-IN-4 is used in COVID-19 research .

HY-150625

*SARS-CoV-2 nsp13-IN-4*	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective nsp13 helicase small-molecule inhibitor and inhibit the ssDNA+ ATPase activity of nsp13 with an IC₅₀ value of 57 μM. SARS-CoV-2 nsp13-IN-4 is agentlike molecule with molecular weight of less than 450Da and can provide a broad-spectrum antiviral effect .

HY-168473

13-TP	SARS-CoV DNA/RNA Synthesis	Infection
13-TP is an inhibitor of SARS-CoV-2. 13-TP effectively inhibits the SARS-CoV-2 central replication transcription complex (C-RTC, nsp12-nsp7-nsp82) catalyzed in vitro RNA synthesis. 13-TP completely inhibits the RdRp polymerization activity. 13-TP blocks the full extension of some of the primer RNA .

HY-155983

E07 aptamer	SARS-CoV	Infection
SARS-CoV-2 nsp14-IN-4 (Compound 12q) is a selective *SARS-CoV-2 nsp14 methyltransferase* inhibitor with an IC₅₀ value of 19 ± 2.5 nM. SARS-CoV-2 nsp14-IN-4 (Compound 12q) do not have a zwitterionic character and can penetrate into cells. SARS-CoV-2 nsp14-IN-4 (Compound 12q) can be used for COVID-19 and its causative agent SARS-CoV-2 research .

HY-150623

*SARS-CoV-2 nsp13-IN-2*	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-2 (Compound C2) is a SARS-CoV-2 non-structural protein 13 (nsp13) small-molecule inhibitor with an IC₅₀ of 42 μM against nsp13 ssDNA ⁺ ATPase .

HY-150624

*SARS-CoV-2 nsp13-IN-3*	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-3 (Compound C3) is a SARS-CoV-2 non-structural protein 13 (nsp13) small-molecule inhibitor with an IC₅₀ of 32 μM against nsp13 ssDNA ⁺ ATPase .

HY-150626

*SARS-CoV-2 nsp13-IN-5*	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-5 (compound C6) is a potent SARS-CoV-2 nsp13 inhibitor with IC₅₀ values of 50 and 55 μM for ssDNA ⁺ ATPase and ssDNA ^- ATPase. SARS-CoV-2 nsp13-IN-5 can be used for researching anti-COVID-19 .

HY-150064

*SARS-CoV-2 nsp3-IN-2*	SARS-CoV	Infection
SARS-CoV-2 nsp3-IN-2 is a macrodomain (Mac1) inhibitor with IC₅₀ value of 180 μM. SARS-CoV-2 nsp3-IN-2 is a small molecule chemical probe and can be used for the research of viral .

HY-150632

*SARS-CoV-2 nsp13-IN-6*	SARS-CoV	Infection
SARS-CoV-2 nsp13-IN-6 (compound C5) is a potent SARS-CoV-2 non-structural protein 13 (nsp13) inhibitor with IC₅₀ values of 27 and 33 μM for ssDNA ⁺ ATPase and ssDNA ^- ATPase. SARS-CoV-2 nsp13-IN-6 can be used for researching anti-COVID-19 .

HY-149321

*SARS-CoV-2 nsp14-IN-3*	SARS-CoV	Infection
SARS-CoV-2 nsp14-IN-3 (4975) is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC₅₀: 3.5 μM) .

HY-150680

*SARS-CoV-2 nsp14-IN-1*	SARS-CoV Histone Methyltransferase DNA Methyltransferase	Infection
SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC₅₀ value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases .

HY-155280

SARS-CoV-2-IN-60	SARS-CoV	Infection
SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible *SARS-CoV-2 nsp16-nsp10 methyltransferase* activity inhibitor with an IC₅₀ of 9 μM and a K_i of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics .

HY-19102

NSP-805	Phosphodiesterase (PDE)	Cardiovascular Disease
NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.

HY-163614

SARS-CoV-2-IN-87	SARS-CoV DNA Methyltransferase	Infection
SARS-CoV-2-IN-87 (compound 138968421) is a potent inhibitor of methyltransferases (nsp14 and nsp16) of SARS-CoV-2 .

HY-168050

nsP2 Protease-IN-1	Virus Protease	Infection
nsP2 Protease-IN-1 is a potent irreversible covalent inhibitor of Chikungunya (CHIKV) *nsP2* cysteine protease with an IC₅₀ value of 60 nM. nsP2 Protease-IN-1 demonstrates potent antialphavirus activity, inhibiting CHIKV and VEEV replication with EC₅₀ = 0.01 and 0.3 µM, respectively .

HY-171189

C-467929	SARS-CoV	Infection
C-467929 is an *Nsp15* endoribonuclease inhibitor with an IC₅₀ of 8 μM. C-467929 binds to the SARS-CoV Nsp15 protein and can be utilized in infection research .

HY-108986

JFD00244	Sirtuin SARS-CoV	Cancer
JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a *Nsp-16* inhibitor against SARS-CoV-2 .

HY-156597

Arbemnifosbuvir AT-752 free base	SARS-CoV	Infection
Arbemnifosbuvir is a nidovirus DdRp-associated nucleotidyltransferase (NiRAN) domain of non-structural protein 12 (nsp12)-interfering drugs. Arbemnifosbuvir can be used for SARS-CoVs infection research .

HY-173199

PRRSV-IN-1	Virus Protease
PRRSV-IN-1 (Compound 4s) is a *nsp4* protease inhibitor targeting PRRSV, exhibiting an EC₅₀ of 0.45 μM against PRRSV. It binds to the *nsp4* protease with a K_d value of 29.24 pM and inhibits *nsp4* protease activity with an IC₅₀ of 80.36 pM. PRRSV-IN-1 can be used for research in the field of antiviral infections .

HY-143467

SARS-CoV-IN-4	SARS-CoV	Infection
SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of *SARS-CoV nsp14 N7-methyltransferase, with an IC₅₀* of 0.6 μM (SARS-CoV nsp14) .

HY-153719

NSC111552	SARS-CoV	Infection
NSC111552 is a potent *SARS-CoV-2 NSP14 MTase* inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC₅₀ of 5.1 μM .

HY-W423489

SARS-CoV-2-IN-76 S-Adenosyl-DL-homocysteine	SARS-CoV	Infection
SARS-CoV-2-IN-76 (compound 1) is a nsp14-viral cap N7 methyltranferase and PLpro inhibitor of severe acute respiratory syndrome corona virus (SARS-CoV-2) .

HY-144798

FWM-5	SARS-CoV	Infection
FWM-5 is a potent *NSP13* helicase inhibitor. SARS-COV-2 NSP13 helicase enzyme plays crucial role in the virus life cycle. FWM-5 has the potential for the research of infection diseases .

HY-D0891

NSP-AS	Fluorescent Dye	Others
NSP-AS is chemiluminescent acridinium substrate II and can be used in homo geneous assays .

HY-W024485

SARS-CoV-2-IN-86	SARS-CoV	Infection
SARS-CoV-2-IN-86 (Compound 2734589) is a dual inhibitor of the methyltransferases nsp14 and nsp16 of SARS-CoV-2. SARS-CoV-2-IN-86 exhibits low toxicity with a LD₅₀ of 700 mg/kg according to toxicity analysis predict .

HY-169102

*CHIKV nsP2 protease-IN-1*	Virus Protease	Infection
CHIKV nsP2 protease-IN-1(compound J13) is an oral active non-structural protein 2 protease inhibitor with the EC₅₀ of 0.39 μM aganist of CHIKV S27. CHIKV nsP2 protease-IN-1 can be used for study of Chikungunya virus .

HY-146987

FWM-3	SARS-CoV	Infection
FWM-3 is a potent *SARS-CoV-2 NSP13 helicase* inhibitor .

HY-144799

FWM-4	SARS-CoV	Infection
FWM-4 is a potent *SARS-COV-2 NSP13 helicase enzyme* inhibitor .

HY-N2014

Verbenalin 1 Publications Verification	SARS-CoV Amyloid-β Ferroptosis Tau Protein Caspase Bcl-2 Family	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the *nsp-12* protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease .

HY-149317

ZINC475239213	SARS-CoV	Infection
ZINC475239213 is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC₅₀: 20 μM) .

HY-149319

ZINC61142882	SARS-CoV	Infection
ZINC61142882 is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC₅₀: 6 μM) .

HY-149322

Z795161988	SARS-CoV	Infection
Z795161988 is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC₅₀: 2.2 μM) .

HY-168441

NCGC00537446	SARS-CoV	Infection
NCGC00537446 is a dual Nsp14 MTase/ExoN inhibitor. NCGC00537446 can be used for the research of SARS-CoV-2 replication and infection .

HY-N14351

Ferrocin A	SARS-CoV Bacterial Antibiotic	Infection
Ferrocin A is a lipopeptide compound that targets the SARS-CoV-2 RNA-dependent RNA polymerase (nsp12). Ferrocin A can stably bind to *nsp12, and as an iron-chelating peptide, it reduces the concentration of free iron in the environment via complexation, thereby inhibiting bacterial* growth by repressing the acquisition of essential metal cations. As an iron-chelating antiviral molecule, Ferrocin A may be used in studies related to COVID-19 and bacterial infections .

HY-149320

Acryl42-10	SARS-CoV	Infection
Acryl42-10 is a covalent inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC₅₀: 7 μM) .

HY-N2014R

Verbenalin (Standard)	SARS-CoV Amyloid-β Ferroptosis Tau Protein Caspase Bcl-2 Family	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Verbenalin (Standard) is the analytical standard of Verbenalin. This product is intended for research and analytical applications. Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the *nsp-12* protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease .

HY-161762

RA-0002034	Virus Protease	Infection
RA-0002034 is a *Chikungunya virus (CHIKV) nsP2 protease* inhibitor with an IC₅₀ of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .

HY-161762A

(E/Z)-RA-0002034	Influenza Virus	Cancer
(E/Z)-RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.

HY-157439

SARS-CoV-2-IN-72	SARS-CoV	Infection
SARS-CoV-2-IN-72 (compound 12) is a potent allosteric inhibitor of the SARS-COV-2 papain-like protease domain that can trigger the degradation of NSP3 .

HY-D0892

NSP-DMAE-NHS	Biochemical Assay Reagents	Others
NSP-DMAE-NHS is an acridinium ester chemiluminescence reagent containing N-sulfopropyl group. It is useful in the clinical diagnostics industry, especially in automated immunochemistry analyzers such as the ADVIA Centaur system from Siemens Healthcare Diagnostics.

HY-105721

Aranotin	SARS-CoV	Infection
Aranotin strongly binds to Nsp15 viral protein. Aranotin can be used as promising SARS-CoV-2 replication strong inhibitor. Aranotin has the potential for COVID-19 research .

HY-162177

SARS-CoV-2-IN-78	SARS-CoV	Infection
SARS-CoV-2-IN-78 (compound 3) is an inhibitor for nsp14 of SARS-Cov-2. SARS-CoV-2-IN-78 reveals antiviral activity as N7 methyltrabsferase .

HY-149362

MTase-IN-1	SARS-CoV	Infection
MTase-IN-1 (compound 26) is a potent and selective inhibitor of *coronavirus nsp14 N7-methyltransferases, with an IC₅₀* of 0.72 nM. MTase-IN-1 impairs viral RNA translation and immune evasion .

Cat. No.	Product Name

HY-L052

Anti-COVID-19 Compound Library

1,461 compounds

COVID-19 poses a serious threat to people's health, and it is urgent to develop drugs to treat COVID-19 quickly. The screening of anti-COVID-19 drugs by using the clinical and approved compounds can greatly shorten the research and development cycle. In addition, the virtual screening technology can effectively narrow the scope of screening and improve the screening efficiency in the pre-screening of new drugs.

Taking advantage of our virtual screening, we conduct virtual screening of approved compound library and clinical compound library based on the 3CL protease (PDB ID: 6LU7), Spike Glycoprotein (PDB ID: 6VSB), NSP15 (PDB ID: 6VWW), RDRP, PLPro and ACE2 (Angiotensin Converting Enzyme 2) structure. We design a unique collection of 1,461 compounds which may have anti-COVID-19 activity. Anti-COVID-19 Compound Library will be a powerful tool for screening new anti-COVID-19 activity drugs.

Cat. No.	Product Name	Type

HY-D0893

NSP-SA-NHS	Fluorescent Dyes/Probes
NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed .

Cat. No.	Product Name	Target	Research Area

HY-P5416

GGASCCLYCRCH	Peptides	Others
GGASCCLYCRCH is a biological active peptide. (can inhibit the 2-O-methyltransferase activity of the SARS-CoV complex nsp16/10)

Cat. No.	Product Name		Classification

HY-163785

1"-α-Azido-RDPr		Azide
1"-α-Azido-RDPr (Compound 11) is an analog of adenosine diphosphate ribose, and exhibits inhibitory efficacy against the SARS-CoV-2 nonstructural protein macodomain *SARS-CoV-2 NSP3 Mac1* with an IC₅₀ of 30 nM .

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