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Results for "

Parkin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PINK1/Parkin (8) Aldose Reductase (1) Apoptosis (5) Autophagy (1) Bacterial (1) Deubiquitinase (3) Dopamine Receptor (1) GABA Receptor (1) GSK-3 (1) IFNAR (1) Mitochondrial Metabolism (4) Mitophagy (6) mTOR (2) Oxidative Phosphorylation (2) p62 (1) Prolyl Endopeptidase (PREP) (2) STING (1) α-synuclein (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (7)

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Targets Recommended: PINK1/Parkin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139308

T0467 1 Publications Verification	PINK1/Parkin Mitochondrial Metabolism	Neurological Disease
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research .

HY-145337

FT3967385 FT385	PINK1/Parkin Deubiquitinase	Cancer
FT3967385 is a novel USP30 inhibitor that recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

HY-162325

WJ-39	Aldose Reductase Mitochondrial Metabolism Apoptosis Mitophagy	Metabolic Disease
WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis .

HY-115576

P62-mediated mitophagy inducer 4 Publications Verification PMI	p62 Mitophagy Autophagy	Neurological Disease Cancer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of *Parkin* or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional *PINK1/Parkin* pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential .

HY-100941

CCCP Maximum Cited Publications 89 Publications Verification Carbonyl cyanide 3-chlorophenylhydrazone; Carbonyl Cyanide m-Chlorophenylhydrazone	Oxidative Phosphorylation PINK1/Parkin STING IFNAR Mitochondrial Metabolism Bacterial Apoptosis	Inflammation/Immunology Cancer
CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

HY-100410

FCCP 50+ Cited Publications Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone	Oxidative Phosphorylation PINK1/Parkin Mitochondrial Metabolism	Cancer
FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

HY-141659

CMPD-39 1 Publications Verification	Deubiquitinase	Cancer
CMPD-39 is a selective USP30 inhibitor with an IC₅₀ of 0.02 μM. CMPD-39 increases protein ubiquitination and accelerates mitophagy .

HY-152265

PARL-IN-1	PINK1/Parkin Mitophagy	Neurological Disease
PARL-IN-1 is a potent PARL inhibitor with an IC₅₀ value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy .

HY-152265A

PARL-IN-1 TFA	PINK1/Parkin Mitophagy	Neurological Disease
PARL-IN-1 TFA is a potent PARL inhibitor with an IC₅₀ value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy .

HY-138978

MF-095	Mitophagy Deubiquitinase	Neurological Disease
MF-095 is a USP30 inhibitor. MF-095 promotes mitochondrial autophagy. MF-095 can be used in neurological disease-related research .

HY-N0109

Salidroside 20+ Cited Publications Rhodioloside	PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)	Cancer
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-153089

GSK3-IN-3 2 Publications Verification	GSK-3 Mitophagy	Neurological Disease
GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC₅₀ value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA .

HY-N0109R

Salidroside (Standard) Rhodioloside (Standard)	Prolyl Endopeptidase (PREP) mTOR Apoptosis PINK1/Parkin	Cancer
Salidroside (Standard) is the analytical standard of Salidroside. This product is intended for research and analytical applications. Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy .

HY-121152

Chiisanoside	α-synuclein Apoptosis GABA Receptor Dopamine Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Chiisanoside exhibits neuroprotective, anticancer, antidepressant, anti-inflammatory, anti-obesity and anti-platelet activities. Chiisanoside inhibits tumor growth in H22 xenograft mouse model, through immunoregulation, induction of apoptosis and inhibition of angiogenesis. Chiisanoside attenuates Parkinson’s disease through regulation of Parkin/ZNF746/PGC-1α axis, and promotion of mitochondrial biogenesis .

HY-B0824A

(1R)-cis-Bifenthrin	Others	Others
(1R)-cis-Bifenthrin is a widely used pyrethroid pesticide with activity that reduces motor coordination. (1R)-cis-Bifenthrin has a significant impact on the motor function of ParK_in-/- mice, as shown by increased pole climbing time and wheel running Time decreases. Exposure of (1R)-cis-Bifenthrin resulted in a significant reduction in tyrosine hydroxylase-positive cell counts and protein expression. (1R)-cis-Bifenthrin caused increased expression of mitophagy-related proteins LC3B and p62. (1R)-cis-Bifenthrin has a lower binding energy with transferrin and transferrin receptor 2, showing stronger interactions. The biological effects of (1R)-cis-Bifenthrin show relationships with mitophagy and ferroptosis-related pathways .

Salidroside 20+ Cited Publications Rhodioloside	Structural Classification Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Phenols Plants Disease Research Fields Cancer	PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

Salidroside (Standard) Rhodioloside (Standard)	Structural Classification Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Source classification Phenols Plants Disease Research Fields Cancer	Prolyl Endopeptidase (PREP) mTOR Apoptosis PINK1/Parkin
Salidroside (Standard) is the analytical standard of Salidroside. This product is intended for research and analytical applications. Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy .

Chiisanoside	Eleutherococcus henryi var. faberi (Harms) S. Y. Hu Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	α-synuclein Apoptosis GABA Receptor Dopamine Receptor
Chiisanoside exhibits neuroprotective, anticancer, antidepressant, anti-inflammatory, anti-obesity and anti-platelet activities. Chiisanoside inhibits tumor growth in H22 xenograft mouse model, through immunoregulation, induction of apoptosis and inhibition of angiogenesis. Chiisanoside attenuates Parkinson’s disease through regulation of Parkin/ZNF746/PGC-1α axis, and promotion of mitochondrial biogenesis .

Species:	Human (2) Mouse (1)
Tag:	SUMO (1) His (2) Myc (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702810

	PRKN Protein, Mouse (GST) E3 ubiquitin-protein ligase Parkin; Parkin; PARK2; Parkin RBR E3 ubiquitin-protein ligase	Mouse	E. coli
	PRKN Protein, Mouse (GST) is the recombinant mouse-derived PRKN, expressed by E. coli , with N-GST labeled tag. ,

HY-P702806

	PRKN Protein, Human (His, SUMO) E3 ubiquitin-protein ligase Parkin; Parkin; PARK2; Parkin RBR E3 ubiquitin-protein ligase	Human	E. coli

HY-P702807

	PRKN Protein, Human (sf9, His, Myc) E3 ubiquitin-protein ligase Parkin; Parkin; PARK2; Parkin RBR E3 ubiquitin-protein ligase	Human	Sf9 insect cells
	PRKN Protein, Human (sf9, His, Myc) is the recombinant human-derived PRKN, expressed by Sf9 insect cells , with C-Myc, N-10*His labeled tag. ,

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HY-P80779

	Parkin Antibody AR-JP; LPRS2; PARK2; Parkin; Parkin 2; PDJ; PRKN; PRKN2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Parkin Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 52 kDa, targeting to Parkin. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P83206

	GPR37 Antibody (YA2951) GPR37; Probable G-protein coupled receptor 37; Endothelin B receptor-like protein 1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor; PAELR	WB	Rat
	GPR37 Antibody (YA2951) is a biotin-conjugated non-conjugated IgG antibody, targeting GPR37, with a predicted molecular weight of 67 kDa (observed band size: 67 kDa). GPR37 Antibody (YA2951) can be used for WB experiment in rat background.

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Parkin

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