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Results for "

Potassium oxalate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/K+ ATPase (1) 5-HT Receptor (10) Adrenergic Receptor (1) Akt (1) Apoptosis (1) ATM/ATR (1) Autophagy (2) Biochemical Assay Reagents (9) c-Met/HGFR (2) Calcium Channel (1) Carbonic Anhydrase (1) EGFR (1) Endogenous Metabolite (1) Ephrin Receptor (1) Epigenetic Reader Domain (2) Fluorescent Dye (1) GLUT (2) Histamine Receptor (2) HIV (1) Influenza Virus (1) Isotope-Labeled Compounds (11) mAChR (2) nAChR (1) Neurokinin Receptor (2) Opioid Receptor (2) Parasite (1) Phosphatase (1) Prolyl Endopeptidase (PREP) (1) Serotonin Transporter (7) Sigma Receptor (3) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (4) Endocrinology (1) Infection (2) Inflammation/Immunology (2) Metabolic Disease (6) Neurological Disease (29)
Oligonucleotides:	siRNAs (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Potassium Channel Na+/K+ ATPase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0118A

Naloxegol oxalate 2 Publications Verification NKTR-118 oxalate; AZ-13337019 oxalate	Opioid Receptor	Neurological Disease
Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-135810A

Cletoquine oxalate Desethylhydroxychloroquine oxalate	Influenza Virus Parasite	Infection Inflammation/Immunology
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-13410

Xanomeline oxalate 1 Publications Verification LY246708 oxalate	mAChR	Neurological Disease
Xanomeline oxalate (LY246708 oxalate) is a potent and selective muscarinic receptor agonist (SMRA) and stimulates phosphoinositide hydrolysis in vivo. Xanomeline oxalate can be used for the research of Alzheimer’s disease .

HY-W094712

*Potassium oxalate* monohydrate**	Biochemical Assay Reagents	Others
Potassium oxalate monohydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-15718B

Istaroxime oxalate PST2744 oxalate	Na+/K+ ATPase	Cardiovascular Disease
Istaroxime oxalate (PST2744 oxalate) is the oxalate form of Istaroxime (HY-15718). Istaroxime oxalate is is an inotropic agent, that inhibits Na ⁺/K ⁺-ATPase with an IC₅₀ of 0.11 μM. Istaroxime oxalate increases force of contraction in guinea pig atria and twitch amplitude in isolated guinea pig myocytes without causing lethal arrhythmias .

HY-152849A

Boditrectinib oxalate HL5101 oxalate	c-Met/HGFR	Cancer
Boditrectinib oxalate is a potent tyrosine kinase inhibitor. Boditrectinib oxalate serves as an antineoplastic agent. Boditrectinib oxalate is useful in the research of cancer, inflammation, neurodegenerative diseases and certain infectious diseases .

HY-B1107R

*Naftidrofuryl oxalate* (Standard)** Nafronyl oxalate salt (Standard)	5-HT Receptor	Cardiovascular Disease
Naftidrofuryl (oxalate) (Standard) is the analytical standard of Naftidrofuryl (oxalate). This product is intended for research and analytical applications.

HY-W105856

Tin(II) oxalate Stannous oxalate	Biochemical Assay Reagents	Others
Tin(II) oxalate (Stannous oxalate) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-13225

Rivanicline oxalate RJR-2403 oxalate; (E)-Metanicotine oxalate	nAChR	Neurological Disease
Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (K_i=26 nM); > 1,000 fold selectivity than α7 receptors(K_i= 3.6 μM).

HY-14258AR

*Escitalopram oxalate* (Standard)** (S)-Citalopram oxalate (Standard); (S)-(+)-Citalopram oxalate (Standard)	Serotonin Transporter	Neurological Disease Cancer
Escitalopram (oxalate) (Standard) is the analytical standard of Escitalopram (oxalate). This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-14258A

Escitalopram oxalate 3 Publications Verification (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate	Serotonin Transporter	Neurological Disease Cancer
Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-B1107

Naftidrofuryl oxalate Nafronyl oxalate salt	5-HT Receptor	Cardiovascular Disease
Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.

HY-151098S

Chlorpromazine-d6 oxalate	Isotope-Labeled Compounds	Others
Chlorpromazine-d₆ (oxalate) is the deuterium labeled Chlorpromazine oxalate[1].

HY-E70385

Oxalate Oxidase	Endogenous Metabolite	Others
Oxalate Oxidase, or oxalate oxidase, catalyzes the oxidation of oxalic acid to hydrogen peroxide and carbon dioxide in the presence of oxygen. Oxalate Oxidase can be found in a variety of plants (such as barley) and microorganisms and can be used to treat wastewater and filtrates containing oxalic acid .

HY-A0118AS

Naloxegol-d5 oxalate	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
Naloxegol-d₅ (oxalate) is deuterium labeled Naloxegol (oxalate). Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation[1][2].

HY-121203S1

Citalopram-d6 oxalate	Isotope-Labeled Compounds	Others
Citalopram-d6 oxalate is the deuterium labeled Citalopram oxalate .

HY-14258AS1

Escitalopram-d4 oxalate (S)-Citalopram-d₄ oxalate; (S)-(+)-Citalopram-d₄ oxalate	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-19695

(-)-p-Bromotetramisole oxalate 1 Publications Verification L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate	Phosphatase	Cancer
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

HY-107759

Butabindide oxalate UCL-1397 oxalate	Others	Neurological Disease
Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with K_i values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .

HY-B0102D

Fluoxetine oxalate LY-110140 oxalate	Serotonin Transporter Autophagy	Neurological Disease
Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-14258AS

Escitalopram-d6 oxalate	Serotonin Transporter	Neurological Disease
Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-107656

PTAC oxalate	mAChR	Neurological Disease
PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (K_i values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects .

HY-132373S

N-Hydroxy Mexiletine-d6 Oxalate	Isotope-Labeled Compounds	Others
N-Hydroxy Mexiletine-d₆ Oxalate is the deuterium labeled N-Hydroxy Mexiletine Oxalate[1].

HY-143931S

N-Desmethyl citalopram-d4 oxalate	Isotope-Labeled Compounds	Others
N-Desmethyl citalopram-d₄ (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate[1].

HY-110289R

*(R)-Citalopram oxalate* (Standard)**	Serotonin Transporter 5-HT Receptor	Neurological Disease
(R)-Citalopram (oxalate) (Standard) is the analytical standard of (R)-Citalopram (oxalate). This product is intended for research and analytical applications. (R)-Citalopram oxalate is an anticonvulsant, antidepressant and muscle relaxant. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (Escitalopram; HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate functionally antagonises S-citalopram in vivo and in vitro. (R)-Citalopram oxalate has an effect on the association of Escitalopram with the high affinity primary site, and on its dissociation from the 5-HT transporter, via an allosteric mechanism .

HY-110289S1

(R)-Citalopram-d4 oxalate	Isotope-Labeled Compounds	Others
(R)-Citalopram-d₄ (oxalate) is deuterium labeled (R)-Citalopram Oxalate.

HY-110289

(R)-Citalopram oxalate	Serotonin Transporter 5-HT Receptor	Neurological Disease
(R)-Citalopram oxalate is an anticonvulsant, antidepressant and muscle relaxant. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (Escitalopram; HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate functionally antagonises S-citalopram in vivo and in vitro. (R)-Citalopram oxalate has an effect on the association of Escitalopram with the high affinity primary site, and on its dissociation from the 5-HT transporter, via an allosteric mechanism .

HY-148669B

(S)-Bleximenib oxalate (S)-Menin-MLL inhibitor 24 oxalate	Epigenetic Reader Domain	Cancer
(S)-Bleximenib ((S)-Menin-MLL inhibitor 24) oxalate is a S-Enantiomer of (S)-Menin-MLL inhibitor 24 oxalate (HY-148669A). (S)-Bleximenib oxalate is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer .

HY-103313

SR33805 oxalate	Calcium Channel	Cardiovascular Disease
SR33805 oxalate is a potent Ca ²⁺ channel antagonist, with EC₅₀s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca ²⁺ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts .

HY-12199A

Pitolisant oxalate Tiprolisant oxalate	Histamine Receptor	Neurological Disease Endocrinology
Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (K_i=0.16 nM).

HY-151910S1

*(±)-Fluoxetine-d5 Oxalate* (phenyl-d5)**	Isotope-Labeled Compounds	Others
(±)-Fluoxetine-dd₅ Oxalate (phenyl-dd₅) is the deuterium labeled (±)-Fluoxetine Oxalate[1].

HY-107460

LDN-211904 oxalate	Ephrin Receptor	Cancer
LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC₅₀ of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC .

HY-149854A

AB21 oxalate	Sigma Receptor	Neurological Disease
AB21 oxalate is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 oxalate has the effect of reducing mechanical hypersensitivity .

HY-111081C

(±)-PPCC oxalate	Sigma Receptor	Neurological Disease
(±)-PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with K_i of 1.5 nM. (±)-PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats .

HY-107557A

Proxyfan Oxalate	Histamine Receptor	Neurological Disease
Proxyfan Oxalate is a potent histamine H3 receptor antagonist with K_i values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan Oxalate is over 1000-fold more potent at H3 receptors than other histamine receptors .

HY-151910S

*(±)-Fluoxetine-d4 Oxalate* (trifluoromethylphen-d4-oxy)**	Isotope-Labeled Compounds	Others
(±)-Fluoxetine-d₄ Oxalate (trifluoromethylphen-d₄-oxy) is the deuterium labeled (±)-Fluoxetine Oxalate[1].

HY-19668A

SGS518 oxalate	5-HT Receptor	Neurological Disease
SGS518 oxalate is a selective 5-HT₆R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses ^[1]

HY-110366

WAY-181187 oxalate SAX-187 oxalate	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-107758

Y-29794 oxalate	Prolyl Endopeptidase (PREP)	Cancer
Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM) .

HY-103098

EMDT oxalate	5-HT Receptor	Neurological Disease
EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects .

HY-W115775

Potassium hydrogen oxalate	Biochemical Assay Reagents	Others
Potassium hydrogen oxalate is a kind of biological materials or organic compounds that are widely used in life science research .

HY-101225

8 Hydroxy PIPAT oxalate	Others	Inflammation/Immunology
8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that promotes the release of histamine from enteric mast cells. 8 Hydroxy PIPAT oxalate activates serotonergic signaling pathways, leading to the degranulation of mast cells in both guinea pig and human intestinal preparations. 8 Hydroxy PIPAT oxalate enhances the spontaneous release of histamine, which may contribute to the regulation of gastrointestinal functions. 8 Hydroxy PIPAT oxalate has potential implications for understanding and treating functional gastrointestinal disorders such as irritable bowel syndrome.

HY-126568S1

Nafronyl-d4 oxalate	Isotope-Labeled Compounds	Others
Nafronyl-d₄ (oxalate) is deuterium labeled Naftidrofuryl.

HY-108512A

PD 144418 oxalate 1 Publications Verification	Sigma Receptor	Neurological Disease
PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (K_i values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 oxalate shows potential antipsychotic activity .

HY-137966A

N-Desethyl Brinzolamide oxalate AL-8520 oxalate	Carbonic Anhydrase	Cancer
N-Desethyl Brinzolamide oxalate is a dual inhibitor of Carbonic anhydrase II and Carbonic anhydrase IV with IC₅₀s of 1.28 and 128 nM, respectively .

HY-101309A

5-(Nonyloxy)tryptamine oxalate	Others	Cancer
5-(Nonyloxy)tryptamine oxalate, a high-affinity agonist for the 5-HTIDβ receptor, with an ED₅₀ value of 68 nM. 5-(Nonyloxy)tryptamine oxalate, exhibits antitumor growth activity in vivo and enhances the ability of T cells to target tumor cells .

HY-W127854

Bis(pentafluorophenyl) oxalate	Biochemical Assay Reagents	Others
Bis(pentafluorophenyl) Oxalate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-148669A

Bleximenib oxalate Menin-MLL inhibitor 24 oxalate	Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor 24 (compound A) oxalate is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer .

HY-136835

GJ071 oxalate	ATM/ATR	Neurological Disease
GJ071 oxalate induces ATM kinase activity in ataxia telangiectasia (A-T) cells carrying homozygous TGA or TAG stop codons .

HY-10261D

Afatinib oxalate BIBW 2992 oxalate	EGFR Autophagy Apoptosis c-Met/HGFR Akt	Cancer
Afatinib (BIBW 2992) oxalate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC₅₀ values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR ^wt, EGFR ^L858R, EGFR ^L858R/T790M and HER2, respectively. Afatinib oxalate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .

Cat. No.	Product Name	Target	Research Area

HY-110366

WAY-181187 oxalate SAX-187 oxalate	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

Cat. No.	Product Name	Chemical Structure

HY-151910S1

*(±)-Fluoxetine-d5 Oxalate* (phenyl-d5)**
(±)-Fluoxetine-dd₅ Oxalate (phenyl-dd₅) is the deuterium labeled (±)-Fluoxetine Oxalate[1].

HY-151098S

Chlorpromazine-d6 oxalate
Chlorpromazine-d₆ (oxalate) is the deuterium labeled Chlorpromazine oxalate[1].

HY-A0118AS

Naloxegol-d5 oxalate
Naloxegol-d₅ (oxalate) is deuterium labeled Naloxegol (oxalate). Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation[1][2].

HY-121203S1

Citalopram-d6 oxalate
Citalopram-d6 oxalate is the deuterium labeled Citalopram oxalate .

HY-14258AS1

Escitalopram-d4 oxalate

Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-14258AS

Escitalopram-d6 oxalate

Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-132373S

N-Hydroxy Mexiletine-d6 Oxalate
N-Hydroxy Mexiletine-d₆ Oxalate is the deuterium labeled N-Hydroxy Mexiletine Oxalate[1].

HY-143931S

N-Desmethyl citalopram-d4 oxalate
N-Desmethyl citalopram-d₄ (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate[1].

HY-110289S1

(R)-Citalopram-d4 oxalate
(R)-Citalopram-d₄ (oxalate) is deuterium labeled (R)-Citalopram Oxalate.

HY-151910S

*(±)-Fluoxetine-d4 Oxalate* (trifluoromethylphen-d4-oxy)**
(±)-Fluoxetine-d₄ Oxalate (trifluoromethylphen-d₄-oxy) is the deuterium labeled (±)-Fluoxetine Oxalate[1].

HY-126568S1

Nafronyl-d4 oxalate
Nafronyl-d₄ (oxalate) is deuterium labeled Naftidrofuryl.

HY-132475S

rac-Duloxetine-d3 oxalate
rac Duloxetine 3-Thiophene Isomer-d3 Oxalate is a stable isotope of Duloxetine.

Cat. No.	Product Name		Classification

HY-132613

Lumasiran sodium		siRNAs
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-132588

Lumasiran ALN-G01		siRNAs
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) .

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