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Results for "

Pyrrolizidine alkaloids

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (3) Cholinesterase (ChE) (3) Cytochrome P450 (2) DNA/RNA Synthesis (1) Endogenous Metabolite (3) Glutathione S-transferase (2) Isotope-Labeled Compounds (2) mAChR (1) Mitochondrial Metabolism (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (2) Metabolic Disease (10) Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9509

Erucifoline	Others	Others
Erucifoline is a pyrrolizidine alkaloid that can be found in the aerial parts of Senecio aquaticus .

HY-127011

7-Acetylintermedine	Others	Metabolic Disease
7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid .

HY-N2561A

Spartioidine N-oxide	Others	Others
Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-W707957

Intermedine N-oxide	Others	Cancer
Intermedine N-oxide is a pyrrolizidine alkaloid indicine that can be found in Crotalaria spectabilis. Intermedine N-oxide shows anticancer activity .

HY-N7774

Echinatine N-oxide	Others	Others
Echinatine N-oxide is a pyrrolizidine alkaloid found in R. graeca .

HY-N9511

Jacobine N-oxide	Others	Others
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .

HY-133591

Senecivernine	Bacterial	Infection
Senecivernine, a pyrrolizidine alkaloid isolated from Senecio species, exhibits a weakly mutagenic activity .

HY-122927

Symphytine	Others	Cancer
Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity .

HY-N7594

Senecionine acetate O-Acetylsenecionine	Mitochondrial Metabolism	Others
Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca ²⁺ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups .

HY-124140

Heliosupine	Cholinesterase (ChE)	Others
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-122772

(-)-Integerrimine	Others	Inflammation/Immunology
(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila .

HY-113845

(+)-Intermedine	Others	Neurological Disease
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-122916

7-Acetyllycopsamine	Others	Metabolic Disease Inflammation/Immunology
7-Acetyllycopsamine, a pyrrolizidine alkaloid, is a mild hepatotoxin. 7-Acetyllycopsamine can induce liver inflammation in mice .

HY-N2561AR

Spartioidine N-oxide (Standard)	Others	Others
Spartioidine N-oxide (Standard) is the analytical standard of Spartioidine N-oxide. This product is intended for research and analytical applications. Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-124058

Jacobine	Others	Others
Jacobine is a pyrrolizidine alkaloid (PA) from Senecio jacobaea . Jacobine is active against second instar larvae of thrips .

HY-N6931

Usaramine	Bacterial	Infection
Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria .

HY-124140R

Heliosupine (Standard)	Cholinesterase (ChE)	Others
Heliosupine (Standard) is the analytical standard of Heliosupine. This product is intended for research and analytical applications. Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-N6637

Senecionine N-oxide	Others	Cancer
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-N6638

Retrorsine 1 Publications Verification	Others	Metabolic Disease
Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury .

HY-113845R

(+)-Intermedine (Standard)	Others	Neurological Disease
(+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-N6931R

Usaramine (Standard)	Bacterial	Infection
Usaramine (Standard) is the analytical standard of Usaramine. This product is intended for research and analytical applications. Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria .

HY-N6638R

Retrorsine (Standard)	Others	Metabolic Disease
Retrorsine (Standard) is the analytical standard of Retrorsine. This product is intended for research and analytical applications. Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury .

HY-131587

Integerrimine N-oxide	Others	Others
Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring .

HY-N1282

Seneciphylline	Glutathione S-transferase Cytochrome P450	Cancer
Seneciphylline is a toxic pyrrolizidine alkaloid in Gynura japonica . Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities .

HY-131574

Heliosupine N-oxide	mAChR	Neurological Disease
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-N2560

Senecionine Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin	Others	Metabolic Disease
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-133590

Heliotrine N-oxide	Others	Cancer
Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo .

HY-N1282R

Seneciphylline (Standard)	Glutathione S-transferase Cytochrome P450	Cancer
Seneciphylline (Standard) is the analytical standard of Seneciphylline. This product is intended for research and analytical applications. Seneciphylline is a toxic pyrrolizidine alkaloid in Gynura japonica . Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities .

HY-N2560R

Senecionine (Standard)	Others	Metabolic Disease
Senecionine (Standard) is the analytical standard of Senecionine. This product is intended for research and analytical applications. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .

HY-N8419

Retronecine (+)-Retronecine	Others	Others
Retronecine ((+)-Retronecine) is a pyrrolizidine alkaloid found in a variety of plants. Retronecine is the most common central core for other pyrrolizidine alkaloids .

HY-N1283

Seneciphyllinine	Others	Metabolic Disease
Seneciphyllinine, a pyrrolizidine alkaloid, is isolated from the roots of Gynura japonica. Pyrrolizidine alkaloids are highly hepatotoxic natural chemicals that produce irreversible chronic and acute hepatotoxic effects on human beings .

HY-116832

Retrorsine N-oxide	Others	Cancer
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-122488

Rinderine Heliotridine trachelanthate	Others	Others
Rinderine (Heliotridine trachelanthate) is a pyrrolizidine alkaloid .

HY-N8623

Trachelanthamine	Others	Others
Trachelanthamine is a pyrrolizidine alkaloid isolated from the plant .

HY-131578

Rinderine N-oxide	Others	Metabolic Disease
Rinderine N-oxide is a pyrrolizidine alkaloid that can be found in R. graeca .

HY-124916

Lycopsamine	Others	Cancer
Lycopsamine, a pyrrolizidine alkaloid, is a potential antitumor agent isolated from Eupatorium maculatum L. .

HY-126128

Heliotrine	Others	Cancer
Heliotrine is a monoester pyrrolizidine alkaloid and is used for obtaining models of hepatitis and cirrhosis of the liver .

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Others	Cancer
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .

HY-N9512

Lycopsamine N-oxide	Others	Others
Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen .

HY-N9513

Echimidine N-oxide	Cholinesterase (ChE)	Neurological Disease
Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC_{50=0.347 mM) .}

HY-122509

Senkirkin Senkirkine; Renardin	Others	Others
Senkirkin, a pyrrolizidine alkaloid, occured in the aerial parts of the medicinal plant Tussilago farfara, could induce chromosome damage in human lymphocytes .

HY-122099

Riddelline	DNA/RNA Synthesis	Others
Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver .

HY-133589

Fulvine	Others	Cardiovascular Disease Metabolic Disease
Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is hepatotoxic and can be used to induce hypertensive pulmonary vascular disease in vivo .

HY-126760

Retroisosenine	Others	Others
Retroisosenine is a pyrrolizidine alkaloid isolated from the plant of the genus Senecio. Its specific mechanism of activity and application details are not described in detail from the existing information.

HY-124413

Otosenine	Others	Cardiovascular Disease Neurological Disease
Otosenine is a natural pyrrolizidine alkaloid. Otosenine can be isolated from the aerial parts of the golden ragwort, Senecio aureus. Otosenine has spasmolytic and hypotensive properties .

HY-142063

Petasitenine Fukinotoxin	Endogenous Metabolite	Others
Petasitenine (Fukinotoxin) is a pyrrolizidine alkaloid that can be found in the plant Petasites japonicus, which is a carcinogenic metabolite of neopetasitenine. Petasitenine causes lactate dehydrogenase leakage, and exhibits hepatotoxicity .

HY-124916R

Lycopsamine (Standard)	Others	Cancer
Lycopsamine (Standard) is the analytical standard of Lycopsamine. This product is intended for research and analytical applications. Lycopsamine, a pyrrolizidine alkaloid, is a potential antitumor agent isolated from Eupatorium maculatum L. .

HY-121390

Lasiocarpine	Endogenous Metabolite	Cancer
Lasiocarpine, a *hepatotoxic pyrrolizidine* alkaloid (PA)*, causes fatal liver veno-occlusive disease in vivo*. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-121390A

Lasiocarpine hydrochloride	Endogenous Metabolite	Cancer
Lasiocarpine hydrochloride, a *hepatotoxic pyrrolizidine* alkaloid (PA)*, causes fatal liver veno-occlusive disease in vivo*. Lasiocarpine hydrochloride is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-N9512S

Lycopsamine N-oxide-d3	Isotope-Labeled Compounds	Others
Lycopsamine N-oxide-d₃ is the deuterium labeled Lycopsamine N-oxide. Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen[1].

Cat. No.	Product Name

HY-L071

Alkaloids Library

547 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 547 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Category	Target	Chemical Structure