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Results for "

SMARCA4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Epigenetic Reader Domain (38) Ligands for E3 Ligase (1) Oxidative Phosphorylation (1) PROTACs (38) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (49)
Click Chemistry:	Azide (10)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144896

FHT-1015 1 Publications Verification	Epigenetic Reader Domain	Cancer
FHT-1015 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 67) .

HY-144897

FHT-1204	Epigenetic Reader Domain	Cancer
FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 70) .

HY-149026

GNE-064	Epigenetic Reader Domain	Others
GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of *SMARCA4, SMARCA2* and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC₅₀ of 0.035 μM and inhibits SMARCA2 with an EC₅₀ of 0.10 μM. GNE-064 possess K_ds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis .

HY-153361

YD23	PROTACs	Cancer
YD23 is a *SMARCA2* PROTAC. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. Moreover, YD23 decreases chromatin accessibility at enhancers of a number of genes including cell cycle and cell growth regulatory genes. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells mechanistically .

HY-156568

SMD-3040	PROTACs Epigenetic Reader Domain	Cancer
SMD-3040 is a potent and selective of *SMARCA2* PROTAC degrader (DC₅₀: 12 nM). SMD-3040 contains SMARCA2/4 ligand, linker and VHL ligand. SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models .

HY-125905

VH032-cyclopropane-F 1 Publications Verification VHL ligand 3; E3 ligase Ligand 19	Ligands for E3 Ligase	Cancer
VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4 .

HY-RS13405

SMARCA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMARCA4 Human Pre-designed siRNA Set A contains three designed siRNAs for SMARCA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMARCA4 Human Pre-designed siRNA Set A SMARCA4 Human Pre-designed siRNA Set A

HY-162835

*PROTAC SMARCA2/4-degrader-28*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of *SMARCA2* and *SMARCA4*(Bliue: CRL2 ^VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) .

HY-162834

*PROTAC SMARCA2/4-degrader-27*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of *SMARCA2* and *SMARCA4. (Blue: CRL2 ^VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA*-BD ligand 1 for PROTAC (HY-44012)) .

HY-169278

*PROTAC SMARCA2 degrader-26*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-26 (compound 45) is a potent *SMARCA2* PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .

HY-149458

FHT-2344	Epigenetic Reader Domain	Cancer
FHT-2344 is a SMARCA4/SMARCA2 ATPase inhibitor with IC₅₀ values of 0.026 μM and 0.013 μM, respectively. FHT-2344 has anticancer activity .

HY-163410

AU-24118	PROTACs Epigenetic Reader Domain	Cancer
AU-24118 is orally bioavailable proteolysis targeting chimera (PROTAC) degrader of mSWI/SNF ATPases (SMARCA2 and *SMARCA4) and PBRM1* .

HY-145388

AU-15330 4 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, *SMARCA2* and *SMARCA4*. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity .

HY-161884

SMARCA2/4-IN-1	Epigenetic Reader Domain	Cancer
SMARCA2/4-IN-1 (compound 1) is a potent *SMARCA2* inhibitor with IC₅₀ values of 3.8, 1.7 µM for SMARCA2, SMARCA4, respectively .

HY-144835

FHD-286 1 Publications Verification	Oxidative Phosphorylation Epigenetic Reader Domain	Cancer
FHD-286 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia .

HY-163871

*PROTAC SMARCA2/4-degrader-18*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))

HY-163868

*PROTAC SMARCA2/4-degrader-15*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-15 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-N3024); Blue: Ligand for E3 Ligase (HY-125845))

HY-163870

*PROTAC SMARCA2/4-degrader-17*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))

HY-162743

*PROTAC SMARCA2/4-degrader-29*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038)) .

HY-162744

*PROTAC SMARCA2/4-degrader-31*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)) .

HY-159461

*PROTAC SMARCA2/4-degrader-9*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-163877

*PROTAC SMARCA2/4-degrader-19*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-163949); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-125845))

HY-162748

*PROTAC SMARCA2/4-degrader-30*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades SMARCA2* in A549 and in MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159684); Blue: ligand for E3 ligase (HY-W382038)) .

HY-153425

*PROTAC SMARCA2 degrader-2*	PROTACs	Cancer
PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC₅₀ of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .

HY-159455

*PROTAC SMARCA2/4-degrader-4*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-128359

ACBI1 4 Publications Verification	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
ACBI1 is a potent and cooperative *SMARCA2, SMARCA4* and PBRM1 degrader with DC₅₀s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis .

HY-169275

*PROTAC SMARCA2 degrader-24*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for *SMARCA2* with a DC₅₀ < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades *SMARCA4* with a DC₅₀ > 10 μM in HeLa .

HY-169272

*PROTAC SMARCA2 degrader-21*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for *SMARCA, that degrades SMARCA2* with a DC₅₀ of 10-50 nM in A549 cell, and degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <1 nM and >100 nM, respectively .

HY-122645

SMARCA2-IN-4	Epigenetic Reader Domain	Cancer
SMARCA2-IN-4 (Compound 26) is an inhibitor for SWI/SNF chromatin remodeling complexe *SMARCA* by targeting the bromodomains. SMARCA2-IN-4 exhibits high affinity for PB1(5), *SMARCA2B* and *SMARCA4* with K_d of 124, 262 and 417 nM .

HY-163875

*PROTAC SMARCA2/4-degrader-22*	PROTACs	Cancer
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163876

*PROTAC SMARCA2/4-degrader-23*	PROTACs	Cancer
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-169270

*PROTAC SMARCA2 degrader-19*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for *SMARCA2, that degrades SMARCA2* in cell A549 and MV411 with a DC₅₀ < 100 nM. PROTAC SMARCA2 degrader-19 degrades *SMARCA4* in cell MV411 with a DC₅₀ > 1000 nM .

HY-159458

*PROTAC SMARCA2/4-degrader-7*	PROTACs	Cancer
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159459

*PROTAC SMARCA2/4-degrader-32*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163869

*PROTAC SMARCA2/4-degrader-16*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162741

*PROTAC SMARCA2/4-degrader-33*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*	PROTACs	Cancer
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*	PROTACs	Cancer
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-119374

BRM/BRG1 ATP Inhibitor-1 Maximum Cited Publications 19 Publications Verification	Epigenetic Reader Domain	Cancer
BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 *(SMARCA2)* and brahma related gene 1 *(BRG1)/SMARCA4* ATPase activity inhibitor, both IC₅₀s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity .

HY-122573

Bromodomain inhibitor-13	Epigenetic Reader Domain	Cancer
Bromodomain inhibitor-13 (Compound 1) is an analog of PFI-3 (HY-12409). Bromodomain inhibitor-13 is a bromodomain-containing protein (BCP) inhibitor. Bromodomain inhibitor-13 targets SMARCA2, SMARCA4, PB1(5), and second bromodomain of PB1 (PB1(2)) with K_D values of 37, 53, 30, and 190 nM, respectively .

HY-161885

SMARCA2-IN-6	Epigenetic Reader Domain	Cancer
SMARCA2-IN-6 is a *SMARCA2* (also known as BRM) inhibitor, with IC₅₀s less than 5 nM for SMARCA2 and SMARCA4. SMARCA2-IN-6 inhibits KRT80 gene expression in H1299 cells (IC₅₀: 26 nM). SMARCA2-IN-6 inhibits proliferation in BRG1-mutant SKMEL5 cells (IC₅₀: 13 nM) .

HY-159449

*PROTAC SMARCA2 degrader-5*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

*PROTAC SMARCA2 degrader-7*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-163873

*PROTAC SMARCA2/4-degrader-20*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2* in A549 and MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-163932))

HY-169279

*PROTAC SMARCA2/4-degrader-34*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent *SMARCA2* and *SMARCA4* PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC₅₀ value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845) .

HY-159460

*PROTAC SMARCA2/4-degrader-8*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-161887

SMARCA2-IN-8	Epigenetic Reader Domain	Cancer
SMARCA2-IN-8 (Compound 13) is an orally active inhibitor for SWI/SNF chromatin remodeling complexe *SMARCA2* (also known as Brahma homologue, BRM) and *SMARCA4* (also known as Brahma-related gene 1, BRG1) with IC₅₀ of 5 and 6 nM. SMARCA2-IN-8 inhibits the proliferation of SMARCA2 mutated cancer cell SKMEL5 with AAC₅₀ of 5 nM. SMARCA2-IN-8 downregulates the SMARCA2-dependent KRT80 gene expression with AAC₅₀ of 10 nM. SMARCA2-IN-8 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice .

HY-162815

*PROTAC SMARCA2/4-degrader-26*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-26 (compound 6) is a PROTAC targeting SMARCA2/4. SMARCA2 and SMARCA4 are genes and cancer targets with complementary functions that catalyze nucleosome movement. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid (HY-46618) (red part), E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and the conjugate composed of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845) ^{[1] ^.}

HY-163872

*PROTAC SMARCA2/4-degrader-10*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent *SMARCA2* degrader with an DC₅₀ value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845)) .

Cat. No.	Compare	Product Name	Species	Source

HY-P71784

	SMARCA4 Protein, Human (P.pastoris, His) ATP dependent helicase SMARCA4; ATP-dependent helicase SMARCA4; Brahma protein like 1; BRG1; BRG1 protein; BRG1-associated factor 190A; MRD16	Human	P. pastoris
	The SMARCA4 protein is a multifaceted regulator of chromatin remodeling that dynamically alters DNA nucleosome topology through ATP-dependent enzymatic activity. As part of the SWI/SNF complex and the CREST-BRG1 complex, it regulates transcriptional processes, coordinating the release and activating recruitment of calcium-dependent repressor complexes. SMARCA4 Protein, Human (P.pastoris, His) is the recombinant human-derived SMARCA4 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of SMARCA4 Protein, Human (P.pastoris, His) is 547 a.a., with molecular weight of ~64.8 kDa.

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HY-P80575

	BRG1 Antibody (YA817) SMARCA4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S	WB, ICC/IF, IP	Human, Mouse
	BRG1 Antibody (YA817) is a non-conjugated and Mouse origined monoclonal antibody about 185 kDa, targeting to BRG1 (6D7). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse.

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Cat. No.	Product Name		Classification

HY-159461

*PROTAC SMARCA2/4-degrader-9*		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

*PROTAC SMARCA2/4-degrader-4*		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159458

*PROTAC SMARCA2/4-degrader-7*		Azide
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159459

*PROTAC SMARCA2/4-degrader-32*		Azide
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*		Azide
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*		Azide
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159449

*PROTAC SMARCA2 degrader-5*		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

*PROTAC SMARCA2 degrader-7*		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

*PROTAC SMARCA2/4-degrader-8*		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

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