Snail

By Targets:	Adrenergic Receptor (1) Antibiotic (1) Apoptosis (2) Bacterial (1) Bcl-2 Family (1) Estrogen Receptor/ERR (1) FGFR (1) HDAC (1) HIV (1) iGluR (1) Insecticide (1) JNK (1) MDM-2/p53 (1) PAK (1) Parasite (1) Potassium Channel (1) Reverse Transcriptase (1)
By Research Areas:	Cancer (8) Infection (3) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144315

CYD19 Snail/HDAC-IN-1	HDAC	Cancer
CYD19 is a potent *Snail/HDAC* dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC₅₀ of 0.405 μM and potent inhibition against Snail with a K_d of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis .

HY-E70130

*Snailase, Snail* gastrointestinal**	Others	Others
Snailase, Snail gastrointestinal is an enzyme mixture composed of more than 20 enzymes, which is often used for enzymatic hydrolysis of purified flavonoid glycosides. Snailase can be obtained from the digestive tract and includes cellulase, sucrase, hemicellulase, pectinase, polygalacturonase, protease, etc .

HY-117280

GN25	MDM-2/p53	Cancer
GN25 is a specific *p53-Snail* binding** inhibitor with antitumor effects .

HY-B1870

Metaldehyde	Insecticide	Infection
Metaldehyde is a commonly used pesticide for mollusks such as slugs and snails.

HY-126106

(BrMT)2	Potassium Channel	Others
(BrMT)2 (compound 2) is a non-peptide snail toxin that slows down the activation of Kv1.1 channels .

HY-159130

AO-022	Others	Cancer
AO-022 is a potent TALDO1 allosteric inhibitor. AO-022 decreases the expression of vimentin and snail. AO-022 shows antiproliferative activity and antitumor activity. AO-022 has the potential for the research of breast cancer .

HY-161253

OSU-ERb-12	Estrogen Receptor/ERR	Cancer
OSU-ERb-12 is a ERβ agonist, and suppress ovarian cancer cell proliferation in vitro and in vivo. OSU-ERb-12 decreases the expression of *Snail* .

HY-N0531

Filixic acid ABA	Parasite	Infection
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an LD₅₀ of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-162153

CYY292	FGFR	Cancer
CYY292 is an FGFR1 inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro .

HY-142074

Inophyllum B (+)-Inophyllum B	Reverse Transcriptase HIV	Infection
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits HIV-1 (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .

HY-P1287

Conantokin-T	iGluR	Neurological Disease
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC₅₀ value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa .

HY-N10449

Resistomycin	Antibiotic Apoptosis Bacterial	Cancer
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

HY-146681

PAK1-IN-1	PAK	Cancer
PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC₅₀ of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner .

HY-150596

CT1-3	Apoptosis Bcl-2 Family JNK	Cancer
CT1-3 is a potent anticancer agent. CT1-3 induces mitochondria-mediated apoptosis by regulating JNK/Bcl-2/Bax/XIAP pathway. CT1-3 suppresses the epithelial mesenchymal transition (EMT) potential of human cancer cells (HCCs) via regulating the E-cadherin/Snail axis, thus inhibits tumorigenesis. CT1-3 has a strong antitumor effect in mice model and exhibits no significant hepatic and renal toxicity .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs .

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library	50 compounds
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 50 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Marine-Sourced Natural Product Library

50 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 50 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Target	Research Area

HY-P1904

*Phe-Met-Arg-Phe Like Peptide, Snail* Helix aspersa**	Peptides	Neurological Disease
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues .

HY-P5166

Lys-Conopressin-G	Peptides	Others
Lys-Conopressin-G, a vasotocin-like peptide, can be isolated from the venom of the worm-hunting snail (conus imperialis) .

HY-P2084

WWamide-1	Peptides	Neurological Disease
WWamide-1 is a neuropeptide, which can be isolated form Achatina fulica. WWamide-1 inhibits central neurons of snails, regulates the snail muscle contraction. WWamide-1 inhibits the contraction of anterior byssus retractor muscle (ABRM), enhances the contraction of the radular traction muscle, through effects on presynaptic and postsynaptic membrane of the muscle .

HY-P1287

Conantokin-T	iGluR	Neurological Disease
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC₅₀ value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1904

*Phe-Met-Arg-Phe Like Peptide, Snail* Helix aspersa**	Natural Products Animals Source classification	Others
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues .

HY-N0531

Filixic acid ABA	Infection Quinones Urticaceae Classification of Application Fields Debregeasia wallichiana (Wedd.) Wedd. Source classification Phenols Polyphenols Benzene Quinones Plants Disease Research Fields	Parasite
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an LD₅₀ of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-142074

Inophyllum B (+)-Inophyllum B	Structural Classification Source classification Rosaceae Coumarins Phenylpropanoids Plants Photinia serratifolia (Desf.) Kalkman	Reverse Transcriptase HIV
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits HIV-1 (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .

HY-N10449

Resistomycin	Microorganisms Source classification Phenols Polyphenols	Antibiotic Apoptosis Bacterial
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81135

	SNAI1 Antibody SNAI1_HUMAN; Zinc finger protein SNAI1; SNAI1; SNAH; SNAI 1; SNA; Snail1; dJ710H13.1; Protein Snail homolog 1 (Protein sna); Protein Snail homolog 1; Protein sna	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
	SNAI1 Antibody is an unconjugated, approximately 29 kDa, rabbit-derived, anti-SNAI1 polyclonal antibody. SNAI1 Antibody can be used for: WB,IHC-P,ICC/IF,ELISA expriments in human,and mouse background without labeling.

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