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Isoforms Recommended:	MAP4K7/TNIK

Results for "

TNIK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Casein Kinase (2) DAPK (1) DYRK (1) MAP4K (5) NF-κB (1) PI3K (1) Pim (1) Small Interfering RNA (siRNA) (3) VEGFR (1) Wnt (4)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

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Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145292

TNIK-IN-2	Others	Cancer
TNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC₅₀ of 1.3337 μM .

HY-156818

TNIK-IN-7	Others	Cancer
TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC₅₀ of 11 nM, that has antitumor activity .

HY-124762

TNIK-IN-1	Others	Cancer
TNIK-IN-1 (Compound 1) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC₅₀ of 65 nM, that has antitumor activity .

HY-156817

TNIK-IN-6	Others	Neurological Disease
TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC₅₀ of 0.93 μM, that plays important roles in neurological and psychiatric disorders .

HY-143437

TNIK-IN-5	Wnt	Cancer
TNIK-IN-5 is an efficient *TNIK* inhibitor with IC₅₀ of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity .

HY-145293

TNIK-IN-3	DAPK	Cancer
TNIK-IN-3 is a potent, selective and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK), with an IC₅₀ of 0.026 μM. TNIK-IN-3 could also inhibit Flt4 (IC₅₀=0.030 μM), Flt1 (IC₅₀=0.191 μM) and DRAK1 (IC₅₀=0.411 μM). TNIK-IN-3 can be used for the research of colorectal cancer .

HY-143436

TNIK-IN-4	Others	Cancer
TNIK-IN-4 is a potent *TNIK* inhibitor with IC₅₀ of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116 .

HY-162314

TNIK-IN-8	Wnt	Cancer
TNIK-IN-8 (Compound 35b) is a potent, orally active TNKI inhibitor with a IC₅₀ value of 6 nM. TNIK-IN-8 has antitumor activity .

HY-156523

TNIK&MAP4K4-IN-1	MAP4K	Cancer
TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC₅₀s of 1.29 nM and <10 nM，respectively，in human hepaticstellate cell LX-2. TNIK&MAP4K4-IN-1 can be used for cancer and fibrosis inhibition .

HY-163478

TNIK-IN-9	NF-κB	Inflammation/Immunology
TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC₅₀ of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models .

HY-RS14831

TNIK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNIK Human Pre-designed siRNA Set A contains three designed siRNAs for TNIK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNIK Human Pre-designed siRNA Set A TNIK Human Pre-designed siRNA Set A

HY-RS14832

Tnik Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnik Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnik gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnik Mouse Pre-designed siRNA Set A Tnik Mouse Pre-designed siRNA Set A

HY-RS14833

Tnik Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnik Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnik gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnik Rat Pre-designed siRNA Set A Tnik Rat Pre-designed siRNA Set A

HY-160623

INS018 055 TNIK&MAP4K4-IN-2	MAP4K	Cancer
INS018 055 (compound 112) is a *TNIK* and MAP4K4 inhibitor with IC₅₀ values of 12-120, 12-120 nM, respectively .

HY-124745

KY-05009	MAP4K Wnt Apoptosis	Cancer
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a K_i of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of *TNIK* and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity .

HY-100830

NCB-0846 3 Publications Verification	Wnt MAP4K	Cancer
NCB-0846 is an orally available *TNIK* inhibitor with an IC₅₀ of 21 nM.

HY-156502

TINK-IN-1	Others	Cancer
TINK-IN-1 (Compound 9) is a potent and selective Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC₅₀ of 8 nM. TINK-IN-1 inhibits colorectal cancer cells viability .

HY-156816

ON 108600	Casein Kinase DYRK	Cancer
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC₅₀s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity .

HY-10371

Pim1/AKK1-IN-1 5 Publications Verification LKB1/AAK1 dual inhibitor	Pim	Cancer
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

HY-111754

DMX-5804 3 Publications Verification	MAP4K	Cardiovascular Disease
DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC₅₀ of 3 nM, a pIC₅₀ of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC₅₀, 8.18), and TNIK/MAP4K7 (pIC₅₀, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice .

HY-N3127

Orobol	Casein Kinase PI3K VEGFR	Metabolic Disease
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

Orobol	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Isoflavones	Casein Kinase PI3K VEGFR
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701646

	TNIK Protein, Human (Sf9) TNIK; TRAF2 and NCK-interacting protein kinase	Human	Sf9 insect cells
	TNIK protein is a key activator of the Wnt signaling pathway and regulates gene expression by phosphorylating TCF4/TCF7L2 at the promoter of Wnt target genes. TNIK is located upstream of the JUN N-terminal pathway and contributes to the complex Wnt signaling cascade. TNIK Protein, Human (Sf9) is the recombinant human-derived TNIK protein, expressed by Sf9 insect cells , with tag free. The total length of TNIK Protein, Human (Sf9) is 304 a.a., .

HY-P701645

	TNIK Protein, Human (Sf9, His) TNIK; TRAF2 and NCK-interacting protein kinase	Human	Sf9 insect cells
	TNIK protein is a key activator of the Wnt signaling pathway and regulates gene expression by phosphorylating TCF4/TCF7L2 at the promoter of Wnt target genes. TNIK is located upstream of the JUN N-terminal pathway and contributes to the complex Wnt signaling cascade. TNIK Protein, Human (Sf9, His) is the recombinant human-derived TNIK protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of TNIK Protein, Human (Sf9, His) is 304 a.a., .

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TNIK Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TNIK Human Pre-designed siRNA Set A contains three designed siRNAs for TNIK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnik Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Tnik Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnik gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnik Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Tnik Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnik gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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