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Results for "

VCAM-1

" in MedChemExpress (MCE) Product Catalog:

23

Inhibitors & Agonists

3

Peptides

4

Inhibitory Antibodies

11

Natural
Products

6

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2110

    Akt Inflammation/Immunology
    Phellopterin is a natural product isolated from Angelica dahurica. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium [1].
    Phellopterin
  • HY-108831A
    Natalizumab (Solution)
    2 Publications Verification

    Integrin Inflammation/Immunology
    Natalizumab (Solution) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses [1].
    Natalizumab (Solution)
  • HY-N0617
    Sanggenon C
    2 Publications Verification

    Phosphatase ERK NF-κB Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities [1] .
    Sanggenon C
  • HY-N0602
    Ginsenoside Rg2
    2 Publications Verification

    Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2

    NF-κB Amyloid-β Cardiovascular Disease Neurological Disease Cancer
    Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation.
    Ginsenoside Rg2
  • HY-W588250

    Integrin Inflammation/Immunology
    Surfactin C1 is an amphiphilic biosurfactants. Surfactin C1 inhibits leukemic cell (HL-60) adhesion to human umbilical vein endothelial cells (HUVEC). Surfactin C1 inhibits adhesion melecules expression, such as ICAM-1 and VCAM-1 [1].
    Surfactin C1
  • HY-N1990

    PPAR Cardiovascular Disease Inflammation/Immunology
    Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells [1].
    Gypenoside XLIX
  • HY-RS15618

    Small Interfering RNA (siRNA) Others

    VCAM1 Human Pre-designed siRNA Set A contains three designed siRNAs for VCAM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    VCAM1 Human Pre-designed siRNA Set A
    VCAM1 Human Pre-designed siRNA Set A
  • HY-N2110R

    Akt Inflammation/Immunology
    Phellopterin (Standard) is the analytical standard of Phellopterin. This product is intended for research and analytical applications. Phellopterin is a natural product isolated from Angelica dahurica. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium [1].
    Phellopterin (Standard)
  • HY-N10047

    NF-κB PPAR Cardiovascular Disease
    7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis [1].
    7,8-Didehydrocimigenol
  • HY-163712

    Estrogen Receptor/ERR Endocrinology
    17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase [1].
    17-Epiestriol
  • HY-N0602R

    Chikusetsusaponin I(Standard); Panaxoside Rg2(Standard); Prosapogenin C2 (Standard)

    NF-κB Amyloid-β Cardiovascular Disease Neurological Disease Cancer
    Ginsenoside Rg2 (Standard) is the analytical standard of Ginsenoside Rg2. This product is intended for research and analytical applications. Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation.
    Ginsenoside Rg2 (Standard)
  • HY-108831
    Natalizumab
    2 Publications Verification

    Integrin Inflammation/Immunology Cancer
    Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses [1].
    Natalizumab
  • HY-14921

    Others Cardiovascular Disease Inflammation/Immunology
    Elsibucol is a VCAM1 inhibitor for the study of organ transplant rejection. Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. Elsibucol lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury [1] .
    Elsibucol
  • HY-143243

    Apoptosis NF-κB Keap1-Nrf2 Reactive Oxygen Species Cardiovascular Disease
    Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway [1].
    Antioxidant agent-5
  • HY-159179

    Integrin Inflammation/Immunology
    α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model [1].
    α4 integrin receptor antagonist 3
  • HY-100954
    2,4-Diamino-6-hydroxypyrimidine
    1 Publications Verification

    NO Synthase Inflammation/Immunology
    2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production [1] .
    2,4-Diamino-6-hydroxypyrimidine
  • HY-W013812

    Linoleic Acid ethyl ester; Mandenol

    Others Cardiovascular Disease
    Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators [1].
    Ethyl linoleate
  • HY-W013812S2

    Linoleic Acid ethyl ester-d2; Mandenol-d2

    Isotope-Labeled Compounds Cardiovascular Disease
    Ethyl linoleate-d2 (Linoleic Acid ethyl ester-d2; Mandenol-d2) is the deuterium labeled Ethyl linoleate (HY-W013812). Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators [1] .
    Ethyl linoleate-d2
  • HY-W013812R

    Others Cardiovascular Disease
    Ethyl linoleate (Standard) is the analytical standard of Ethyl linoleate. This product is intended for research and analytical applications. Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators [1].
    Ethyl linoleate (Standard)
  • HY-N7931
    Regaloside A
    1 Publications Verification

    NO Synthase NF-κB Inflammation/Immunology
    Regaloside A, a phenylpropanoid, shows significant DPPH radical scavenging activity of 58.0% at 160 ppm. Regaloside A has anti-inflammatory activity [1].
    Regaloside A
  • HY-B2068

    Iron saccharate

    Reactive Oxygen Species Metabolic Disease Cancer
    Iron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose has the potential for iron deficiency anemia treatment [1] .
    Iron sucrose
  • HY-P1259

    Proteasome Bacterial Inflammation/Immunology
    PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice [1] .
    PR-39
  • HY-P1259A

    Proteasome Bacterial Inflammation/Immunology
    PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice [1] .
    PR-39 TFA

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